PMID- 27749845
OWN - NLM
STAT- MEDLINE
DCOM- 20170907
LR  - 20240324
IS  - 1546-1718 (Electronic)
IS  - 1061-4036 (Print)
IS  - 1061-4036 (Linking)
VI  - 48
IP  - 12
DP  - 2016 Dec
TI  - Genome-wide association analyses identify new susceptibility loci for oral cavity 
      and pharyngeal cancer.
PG  - 1544-1550
LID - 10.1038/ng.3685 [doi]
AB  - We conducted a genome-wide association study of oral cavity and pharyngeal cancer 
      in 6,034 cases and 6,585 controls from Europe, North America and South America. 
      We detected eight significantly associated loci (P < 5 x 10(-8)), seven of which 
      are new for these cancer sites. Oral and pharyngeal cancers combined were 
      associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, 
      LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two 
      new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with 
      known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, 
      CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte 
      antigen (HLA) region, and classical HLA allele imputation showed a protective 
      association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 
      (odds ratio (OR) = 0.59, P = 2.7 x 10(-9)). Stratified analyses on a subgroup of 
      oropharyngeal cases with information available on human papillomavirus (HPV) 
      status indicated that this association was considerably stronger in HPV-positive 
      (OR = 0.23, P = 1.6 x 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers.
FAU - Lesseur, Corina
AU  - Lesseur C
AD  - International Agency for Research on Cancer (IARC/WHO), Lyon, France.
FAU - Diergaarde, Brenda
AU  - Diergaarde B
AD  - Department of Epidemiology, Graduate School of Public Health, University of 
      Pittsburgh, Pittsburgh, Pennsylvania, USA.
AD  - University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
FAU - Olshan, Andrew F
AU  - Olshan AF
AD  - Department of Epidemiology, Gillings School of Global Public Health, University 
      of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
AD  - UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, USA.
FAU - Wunsch-Filho, Victor
AU  - Wunsch-Filho V
AD  - Faculdade de Saude Publica, Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - Ness, Andrew R
AU  - Ness AR
AD  - National Institute for Health Research (NIHR) Biomedical Research Unit in 
      Nutrition, Diet and Lifestyle at the University Hospitals Bristol NHS Foundation 
      Trust and the University of Bristol, Bristol, UK.
AD  - School of Oral and Dental Sciences, University of Bristol, Bristol, UK.
FAU - Liu, Geoffrey
AU  - Liu G
AD  - Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
FAU - Lacko, Martin
AU  - Lacko M
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University 
      Medical Center, Maastricht, the Netherlands.
FAU - Eluf-Neto, Jose
AU  - Eluf-Neto J
AD  - Departamento de Medicina Preventiva, Faculdade de Medicina da Universidade de Sao 
      Paulo, Sao Paulo, Brazil.
FAU - Franceschi, Silvia
AU  - Franceschi S
AD  - International Agency for Research on Cancer (IARC/WHO), Lyon, France.
FAU - Lagiou, Pagona
AU  - Lagiou P
AD  - Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, 
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Macfarlane, Gary J
AU  - Macfarlane GJ
AD  - School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, 
      Aberdeen, UK.
FAU - Richiardi, Lorenzo
AU  - Richiardi L
AD  - Department of Medical Sciences, University of Turin, Turin, Italy.
FAU - Boccia, Stefania
AU  - Boccia S
AD  - Section of Hygiene, Institute of Public Health, Universita Cattolica del Sacro 
      Cuore, Fondazione Policlinico 'Agostino Gemelli', Rome, Italy.
FAU - Polesel, Jerry
AU  - Polesel J
AD  - Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, Aviano, Italy.
FAU - Kjaerheim, Kristina
AU  - Kjaerheim K
AD  - Cancer Registry of Norway, Oslo, Norway.
FAU - Zaridze, David
AU  - Zaridze D
AD  - Department of Cancer Epidemiology and Prevention, Institute of Carcinogenesis, 
      N.N. Blokhin Russian Cancer Research Centre of the Russian Ministry of Health, 
      Moscow, Russian Federation.
FAU - Johansson, Mattias
AU  - Johansson M
AD  - International Agency for Research on Cancer (IARC/WHO), Lyon, France.
FAU - Menezes, Ana M
AU  - Menezes AM
AD  - Programa de Pos-Graduacao em Epidemiologia, Universidade Federal de Pelotas 
      (UFPel), Pelotas, Brazil.
FAU - Curado, Maria Paula
AU  - Curado MP
AD  - Epidemiology, International Center for Research (CIPE), A.C. Camargo Cancer 
      Center, Sao Paulo, Brazil.
FAU - Robinson, Max
AU  - Robinson M
AD  - Centre for Oral Health Research, Newcastle University, Newcastle, UK.
FAU - Ahrens, Wolfgang
AU  - Ahrens W
AD  - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, 
      Germany.
FAU - Canova, Cristina
AU  - Canova C
AD  - Deparment of Molecular Medicine, University of Padova, Padova, Italy.
FAU - Znaor, Ariana
AU  - Znaor A
AD  - International Agency for Research on Cancer (IARC/WHO), Lyon, France.
AD  - Croatian National Institute of Public Health, Zagreb, Croatia.
FAU - Castellsague, Xavier
AU  - Castellsague X
AD  - Institut Catala d'Oncologia (ICO)-IDIBELL, CIBERESP, l'Hospitalet de Llobregat, 
      Barcelona, Spain.
FAU - Conway, David I
AU  - Conway DI
AD  - School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK.
AD  - NHS National Services Scotland (NSS), Edinburgh, UK.
FAU - Holcatova, Ivana
AU  - Holcatova I
AD  - Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles 
      University, Prague, Czech Republic.
FAU - Mates, Dana
AU  - Mates D
AD  - National Institute of Public Health, Bucharest, Romania.
FAU - Vilensky, Marta
AU  - Vilensky M
AD  - Instituto de Oncologia 'Angel H. Roffo', Universidad de Buenos Aires, Buenos 
      Aires, Argentina.
FAU - Healy, Claire M
AU  - Healy CM
AD  - Trinity College School of Dental Science, Dublin, Ireland.
FAU - Szeszenia-Dabrowska, Neonila
AU  - Szeszenia-Dabrowska N
AD  - Department of Environmental Epidemiology, Nofer Institute of Occupational 
      Medicine, Lodz, Poland.
FAU - Fabianova, Eleonora
AU  - Fabianova E
AD  - Regional Authority of Public Health, Banska Bystrica, Slovakia.
FAU - Lissowska, Jolanta
AU  - Lissowska J
AD  - Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology (MCMCC), 
      Warsaw, Poland.
FAU - Grandis, Jennifer R
AU  - Grandis JR
AD  - Department of Otolaryngology-Head and Neck Surgery, University of California at 
      San Francisco, San Francisco, California, USA.
AD  - Clinical Translational Science Institute, University of California at San 
      Francisco, San Francisco, California, USA.
FAU - Weissler, Mark C
AU  - Weissler MC
AD  - Department of Otolaryngology/Head and Neck Surgery, University of North Carolina 
      at Chapel Hill, Chapel Hill, North Carolina, USA.
FAU - Tajara, Eloiza H
AU  - Tajara EH
AD  - Department of Molecular Biology, School of Medicine of Sao Jose do Rio Preto, Sao 
      Jose do Rio Preto, Brazil.
FAU - Nunes, Fabio D
AU  - Nunes FD
AD  - Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao 
      Paulo, Brazil.
FAU - de Carvalho, Marcos B
AU  - de Carvalho MB
AD  - Department of Head and Neck Surgery, Heliopolis Hospital, Sao Paulo, Brazil.
FAU - Thomas, Steve
AU  - Thomas S
AD  - School of Oral and Dental Sciences, University of Bristol, Bristol, UK.
FAU - Hung, Rayjean J
AU  - Hung RJ
AD  - Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, 
      Canada.
FAU - Peters, Wilbert H M
AU  - Peters WH
AD  - Department of Gastroenterology, Radboud University Nijmegen Medical Center, 
      Nijmegen, the Netherlands.
FAU - Herrero, Rolando
AU  - Herrero R
AD  - International Agency for Research on Cancer (IARC/WHO), Lyon, France.
FAU - Cadoni, Gabriella
AU  - Cadoni G
AD  - Institute of Otorhinolaryngology, Universita Cattolica del Sacro Cuore, 
      Fondazione Policlinico 'Agostino Gemelli', Rome, Italy.
FAU - Bueno-de-Mesquita, H Bas
AU  - Bueno-de-Mesquita HB
AD  - Department for Determinants of Chronic Diseases (DCD), National Institute for 
      Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial 
      College London, London, UK.
AD  - Department of Social and Preventive Medicine, Faculty of Medicine, University of 
      Malaya, Kuala Lumpur, Malaysia.
FAU - Steffen, Annika
AU  - Steffen A
AD  - German Institute of Human Nutrition in Potsdam-Rehbruecke (DIfE), Nuthetal, 
      Germany.
FAU - Agudo, Antonio
AU  - Agudo A
AD  - Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Institut 
      Catala d'Oncologia (ICO)-IDIBELL, l'Hospitalet de Llobregat, Barcelona, Spain.
FAU - Shangina, Oxana
AU  - Shangina O
AD  - Department of Cancer Epidemiology and Prevention, Institute of Carcinogenesis, 
      N.N. Blokhin Russian Cancer Research Centre of the Russian Ministry of Health, 
      Moscow, Russian Federation.
FAU - Xiao, Xiangjun
AU  - Xiao X
AD  - Department of Biomedical Data Sciences, Geisel School of Medicine at Dartmouth, 
      Lebanon, New Hampshire, USA.
FAU - Gaborieau, Valerie
AU  - Gaborieau V
AD  - International Agency for Research on Cancer (IARC/WHO), Lyon, France.
FAU - Chabrier, Amelie
AU  - Chabrier A
AD  - International Agency for Research on Cancer (IARC/WHO), Lyon, France.
FAU - Anantharaman, Devasena
AU  - Anantharaman D
AD  - International Agency for Research on Cancer (IARC/WHO), Lyon, France.
FAU - Boffetta, Paolo
AU  - Boffetta P
AD  - Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New 
      York, USA.
FAU - Amos, Christopher I
AU  - Amos CI
AD  - Department of Biomedical Data Sciences, Geisel School of Medicine at Dartmouth, 
      Lebanon, New Hampshire, USA.
FAU - McKay, James D
AU  - McKay JD
AD  - International Agency for Research on Cancer (IARC/WHO), Lyon, France.
FAU - Brennan, Paul
AU  - Brennan P
AD  - International Agency for Research on Cancer (IARC/WHO), Lyon, France.
LA  - eng
GR  - R01 CA092039/CA/NCI NIH HHS/United States
GR  - P30 ES010126/ES/NIEHS NIH HHS/United States
GR  - U19 CA203654/CA/NCI NIH HHS/United States
GR  - P30 CA047904/CA/NCI NIH HHS/United States
GR  - P30 CA016086/CA/NCI NIH HHS/United States
GR  - P30 CA023108/CA/NCI NIH HHS/United States
GR  - R01 CA090731/CA/NCI NIH HHS/United States
GR  - P50 CA097190/CA/NCI NIH HHS/United States
GR  - 001/WHO_/World Health Organization/International
GR  - MR/N005872/1/MRC_/Medical Research Council/United Kingdom
GR  - U19 CA148127/CA/NCI NIH HHS/United States
GR  - RP-PG-0707-10034/DH_/Department of Health/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20161017
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
RN  - 0 (Genetic Markers)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Markers/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Genetic Variation/*genetics
MH  - *Genome-Wide Association Study
MH  - HLA Antigens
MH  - Haplotypes/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mouth/metabolism/pathology/virology
MH  - Mouth Neoplasms/*genetics/virology
MH  - Papillomaviridae/isolation & purification
MH  - Papillomavirus Infections/*genetics/virology
MH  - Pharyngeal Neoplasms/*genetics/virology
PMC - PMC5131845
MID - EMS69808
COIS- Competing financial interests: The authors declare no competing financial 
      interests.
EDAT- 2016/11/01 06:00
MHDA- 2017/09/08 06:00
PMCR- 2017/04/17
CRDT- 2016/11/08 06:00
PHST- 2016/05/02 00:00 [received]
PHST- 2016/09/01 00:00 [accepted]
PHST- 2016/11/01 06:00 [pubmed]
PHST- 2017/09/08 06:00 [medline]
PHST- 2016/11/08 06:00 [entrez]
PHST- 2017/04/17 00:00 [pmc-release]
AID - ng.3685 [pii]
AID - 10.1038/ng.3685 [doi]
PST - ppublish
SO  - Nat Genet. 2016 Dec;48(12):1544-1550. doi: 10.1038/ng.3685. Epub 2016 Oct 17.