PMID- 27751361
OWN - NLM
STAT- MEDLINE
DCOM- 20180327
LR  - 20181202
IS  - 1532-8503 (Electronic)
IS  - 1051-2276 (Linking)
VI  - 26
IP  - 6
DP  - 2016 Nov
TI  - Protein-Bound Uremic Toxins from Gut Microbiota and Inflammatory Markers in 
      Chronic Kidney Disease.
PG  - 396-400
LID - S1051-2276(16)30080-2 [pii]
LID - 10.1053/j.jrn.2016.07.005 [doi]
AB  - OBJECTIVE: Protein-bound uremic toxins from gut microbiota tend to accumulate in 
      chronic kidney disease (CKD) patients and are poorly removed by current dialysis 
      techniques. These toxins induce inflammation and are associated with 
      cardiovascular disease (CVD). The aim of this study was to report the 
      relationship between uremic toxins and inflammatory and cardiovascular markers in 
      CKD patients. DESIGN: This was a cross sectional study. SUBJECTS: Twenty-one 
      nondialysis patients were included (43% men, 63.0 +/- 7.8 years, glomerular 
      filtration rate: 34.4 +/- 12.5 mL/min) as well as 29 hemodialysis (HD) patients 
      [58% men, 52.7 +/- 10.3 years, time on dialysis 54 (31-94.5 months)]. MAIN OUTCOME 
      MEASURE: Total levels of uremic toxins (IS, p-CS, and IAA) were assessed by 
      high-performance liquid chromatography with fluorescence detection. C-reactive 
      protein, Interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and 
      calprotectin plasma levels were determined by immunometric assays. RESULTS: HD 
      patients presented higher inflammatory markers and uremic toxins levels than 
      nondialysis patients. IL-6 levels were positively correlated with IS (r = 0.49; 
      P = .03), p-CS (r = 0.35; P = .04) and IAA (r = 0.36; P = .03). A positive 
      correlation was also observed between MCP-1 levels with IS (r = 0.72; P = .001), 
      p-CS (r = 0.48; P = .001) and IAA (r = 0.75; P = .0001). Linear regression showed 
      that IS was an independent predictor for IL-6 and MCP-1 levels after adjustment. 
      CONCLUSION: Plasma uremic toxins were associated with higher IL-6 and MCP-1 
      levels in CKD patients, potentially playing a role in the development of CVD.
CI  - Copyright (c) 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All 
      rights reserved.
FAU - Borges, Natalia A
AU  - Borges NA
AD  - Medical Sciences Graduate Program, Federal University Fluminense (UFF), Niteroi, 
      RJ, Brazil. Electronic address: nat_borges_@hotmail.com.
FAU - Barros, Amanda F
AU  - Barros AF
AD  - Cardiovascular Sciences Graduate Program, UFF, Niteroi, RJ, Brazil.
FAU - Nakao, Lia S
AU  - Nakao LS
AD  - Department of Basic Pathology, Federal University of Parana (UFPR), Curitiba, PR, 
      Brazil.
FAU - Dolenga, Carla J
AU  - Dolenga CJ
AD  - Department of Basic Pathology, Federal University of Parana (UFPR), Curitiba, PR, 
      Brazil.
FAU - Fouque, Denis
AU  - Fouque D
AD  - Department of Nephrology, Centre Hopitalier Lyon Sud, INSERM 1060, CENS, 
      Universite de Lyon, France.
FAU - Mafra, Denise
AU  - Mafra D
AD  - Medical Sciences Graduate Program, Federal University Fluminense (UFF), Niteroi, 
      RJ, Brazil; Cardiovascular Sciences Graduate Program, UFF, Niteroi, RJ, Brazil.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Ren Nutr
JT  - Journal of renal nutrition : the official journal of the Council on Renal 
      Nutrition of the National Kidney Foundation
JID - 9112938
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Gastrointestinal Microbiome
MH  - Humans
MH  - Interleukin-6
MH  - Male
MH  - Middle Aged
MH  - *Renal Dialysis
MH  - Renal Insufficiency, Chronic/*microbiology
EDAT- 2016/10/19 06:00
MHDA- 2018/03/28 06:00
CRDT- 2016/10/19 06:00
PHST- 2016/05/22 00:00 [received]
PHST- 2016/07/20 00:00 [revised]
PHST- 2016/07/31 00:00 [accepted]
PHST- 2016/10/19 06:00 [pubmed]
PHST- 2018/03/28 06:00 [medline]
PHST- 2016/10/19 06:00 [entrez]
AID - S1051-2276(16)30080-2 [pii]
AID - 10.1053/j.jrn.2016.07.005 [doi]
PST - ppublish
SO  - J Ren Nutr. 2016 Nov;26(6):396-400. doi: 10.1053/j.jrn.2016.07.005.