PMID- 27752333
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2053-3624 (Print)
IS  - 2053-3624 (Electronic)
IS  - 2053-3624 (Linking)
VI  - 3
IP  - 2
DP  - 2016
TI  - Mast cells and acute coronary syndromes: relationship between serum tryptase, 
      clinical outcome and severity of coronary artery disease.
PG  - e000472
LID - e000472
AB  - OBJECTIVE: To assess the relationship between serum tryptase and the occurrence 
      of major cardiovascular and cerebrovascular events (MACCE) at 2-year follow-up in 
      patients admitted with acute coronary syndrome (ACS). To compare serum tryptase 
      to other validated prognostic markers (maximum high-sensitivity troponin (hs-Tn), 
      C reactive protein (CRP) levels at admission, Synergy between percutaneous 
      coronary intervention with Taxus and Cardiac Surgery (SYNTAX) score). METHODS: We 
      measured serum tryptase at admission in 140 consecutive patients with ACS and in 
      50 healthy controls. The patients' follow-up was maintained for 2 years after 
      discharge. The predictive accuracy of serum tryptase for 2-year MACCE was 
      assessed and compared with hs-Tn, CRP and SYNTAX score. RESULTS: Serum tryptase 
      levels at admission were significantly higher in patients with ACS compared with 
      the control group (p=0.0351). 2 years after discharge, 28/140 patients (20%) 
      experienced MACCE. Serum tryptase levels, maximum hs-Tn measurements and SYNTAX 
      score were higher in patients who experienced MACCE compared with those without 
      (p<0.0001). Conversely, we found no significant association between MACCE and 
      CRP. The predictive accuracy of serum tryptase for MACCE was set at the cut-off 
      point of 6.7 ng/mL (sensitivity 46%, specificity 84%). CONCLUSIONS: In patients 
      with ACS, serum tryptase measured during index admission is significantly 
      correlated to the development of MACCE up to 2 years, demonstrating a possible 
      long-term prognostic role of this biomarker.
FAU - Morici, Nuccia
AU  - Morici N
AD  - Dipartimento Cardiotoracovascolare , SS UTIC/ SC Cardiologia 1-Emodinamica, ASST 
      Grande Ospedale Metropolitano Niguarda Ca' Granda , Milano , Italy.
FAU - Farioli, Laura
AU  - Farioli L
AD  - Department of Laboratory Medicine , ASST Grande Ospedale Metropolitano Niguarda 
      Ca' Granda , Milano , Italy.
FAU - Losappio, Laura Michelina
AU  - Losappio LM
AD  - Department of Allergology and Immunology , ASST Grande Ospedale Metropolitano 
      Niguarda Ca' Granda , Milano , Italy.
FAU - Colombo, Giulia
AU  - Colombo G
AD  - Medicine Department , Milano-Bicocca University , Milan , Italy.
FAU - Nichelatti, Michele
AU  - Nichelatti M
AD  - Service of Biostatistics, Department of Hematology , ASST Grande Ospedale 
      Metropolitano Niguarda Ca' Granda , Milano , Italy.
FAU - Preziosi, Donatella
AU  - Preziosi D
AD  - Department of Allergology and Immunology , ASST Grande Ospedale Metropolitano 
      Niguarda Ca' Granda , Milano , Italy.
FAU - Micarelli, Gianluigi
AU  - Micarelli G
AD  - Department of Allergology and Immunology , ASST Grande Ospedale Metropolitano 
      Niguarda Ca' Granda , Milano , Italy.
FAU - Oliva, Fabrizio
AU  - Oliva F
AD  - Dipartimento Cardiotoracovascolare , SS UTIC/ SC Cardiologia 1-Emodinamica, ASST 
      Grande Ospedale Metropolitano Niguarda Ca' Granda , Milano , Italy.
FAU - Giannattasio, Cristina
AU  - Giannattasio C
AD  - Medicine Department, Milano-Bicocca University, Milan, Italy; Cardiology IV, A. 
      De Gasperis Department, ASST Grande Ospedale Metropolitano Niguarda Ca' Granda, 
      Milan, Italy.
FAU - Klugmann, Silvio
AU  - Klugmann S
AD  - Dipartimento Cardiotoracovascolare , SS UTIC/ SC Cardiologia 1-Emodinamica, ASST 
      Grande Ospedale Metropolitano Niguarda Ca' Granda , Milano , Italy.
FAU - Pastorello, Elide Anna
AU  - Pastorello EA
AD  - Department of Allergology and Immunology , ASST Grande Ospedale Metropolitano 
      Niguarda Ca' Granda , Milano , Italy.
LA  - eng
PT  - Journal Article
DEP - 20160927
PL  - England
TA  - Open Heart
JT  - Open heart
JID - 101631219
PMC - PMC5051537
OTO - NOTNLM
OT  - CORONARY ARTERY DISEASE
EDAT- 2016/10/19 06:00
MHDA- 2016/10/19 06:01
PMCR- 2016/09/27
CRDT- 2016/10/19 06:00
PHST- 2016/05/10 00:00 [received]
PHST- 2016/08/10 00:00 [revised]
PHST- 2016/08/16 00:00 [accepted]
PHST- 2016/10/19 06:00 [pubmed]
PHST- 2016/10/19 06:01 [medline]
PHST- 2016/10/19 06:00 [entrez]
PHST- 2016/09/27 00:00 [pmc-release]
AID - openhrt-2016-000472 [pii]
AID - 10.1136/openhrt-2016-000472 [doi]
PST - epublish
SO  - Open Heart. 2016 Sep 27;3(2):e000472. doi: 10.1136/openhrt-2016-000472. 
      eCollection 2016.