PMID- 27754964
OWN - NLM
STAT- MEDLINE
DCOM- 20170503
LR  - 20220310
IS  - 2191-0251 (Electronic)
IS  - 0334-018X (Linking)
VI  - 29
IP  - 11
DP  - 2016 Nov 1
TI  - Investigation of the inflammatory biomarkers of metabolic syndrome in 
      adolescents.
PG  - 1277-1283
LID - 10.1515/jpem-2016-0136 [doi]
AB  - BACKGROUND: Metabolic syndrome (MetS) is a chronic and multifactorial syndrome 
      characterized by a low-grade chronic inflammation, and a major risk factor for 
      type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). In our study, 
      we aimed to investigate the serum levels of high sensitive C-reactive protein 
      (hs-CRP), haptoglobin (Hp), alpha2-macroglobulin (alpha2-MG), platelet factor-4 (PF-4), 
      fetuin-A, serum amyloid P (SAP) and alpha1-acid glycoprotein (AGP) in an adolescent 
      population with MetS. METHODS: This study was performed in 43 (18 males, 25 
      females) MetS adolescents between the ages of 13 and 17 years (14.70+/-1.15) and 43 
      lean controls were matched for age and sex. The serum levels of Hp, alpha2-MG, PF-4, 
      fetuin-A, SAP and AGP were measured by using a multi-ELISA technique. RESULTS: 
      Serum Hp, fetuin-A (p<0.01) and PF-4, hs-CRP, SAP, AGP (p<0.001) values of the 
      MetS subjects were significantly higher than those of the controls. No difference 
      was found in serum alpha2-MG levels between the MetS and control groups (p=0.184). 
      CONCLUSIONS: This finding suggests the possibility of using these markers in 
      diagnosis of MetS in adolescents to prevent future complications.
FAU - Can, Ummugulsum
AU  - Can U
FAU - Buyukinan, Muammer
AU  - Buyukinan M
FAU - Guzelant, Asuman
AU  - Guzelant A
FAU - Ugur, Ayse
AU  - Ugur A
FAU - Karaibrahimoglu, Adnan
AU  - Karaibrahimoglu A
FAU - Yabanciun, Sukriye
AU  - Yabanciun S
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Pediatr Endocrinol Metab
JT  - Journal of pediatric endocrinology & metabolism : JPEM
JID - 9508900
RN  - 0 (AHSG protein, human)
RN  - 0 (Biomarkers)
RN  - 0 (HP protein, human)
RN  - 0 (Haptoglobins)
RN  - 0 (Orosomucoid)
RN  - 0 (Serum Amyloid P-Component)
RN  - 0 (alpha-2-HS-Glycoprotein)
RN  - 37270-94-3 (Platelet Factor 4)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*analysis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Haptoglobins/*analysis
MH  - Hospitals, Teaching
MH  - Humans
MH  - Insulin Resistance
MH  - Male
MH  - Metabolic Syndrome/*blood/epidemiology/immunology/metabolism
MH  - Orosomucoid/*analysis
MH  - Outpatient Clinics, Hospital
MH  - Platelet Factor 4/*blood
MH  - ROC Curve
MH  - Risk
MH  - Serum Amyloid P-Component/*analysis
MH  - Turkey/epidemiology
MH  - Up-Regulation
MH  - alpha-2-HS-Glycoprotein/*analysis
EDAT- 2016/10/19 06:00
MHDA- 2017/05/04 06:00
CRDT- 2016/11/05 06:00
PHST- 2016/04/06 00:00 [received]
PHST- 2016/08/29 00:00 [accepted]
PHST- 2016/11/05 06:00 [entrez]
PHST- 2016/10/19 06:00 [pubmed]
PHST- 2017/05/04 06:00 [medline]
AID - /j/jpem.ahead-of-print/jpem-2016-0136/jpem-2016-0136.xml [pii]
AID - 10.1515/jpem-2016-0136 [doi]
PST - ppublish
SO  - J Pediatr Endocrinol Metab. 2016 Nov 1;29(11):1277-1283. doi: 
      10.1515/jpem-2016-0136.