PMID- 27755954
OWN - NLM
STAT- MEDLINE
DCOM- 20170208
LR  - 20170208
IS  - 1165-158X (Electronic)
IS  - 0145-5680 (Linking)
VI  - 62
IP  - 11
DP  - 2016 Sep 30
TI  - Lack of association between the TNF-alpha-1031genotypes and generalized aggressive 
      periodontitis disease.
PG  - 63-66
AB  - Periodontal disease is one of the most prevalent inflammatory illnesses and is a 
      main cause of tooth loss in human population. Tumor necrosis factor-alpha (TNF-alpha) 
      gene is one of pro-inflammatory cytokines which has important role in 
      pathogenesis of periodontal disease. The main purpose of this study is to 
      determine genotype abundance of TNF-alpha-1031 gene in both groups of patients and 
      controls, and also investigation of relation of single nucleotide polymorphism 
      (SNP) these genotypes with periodontal disease risk. DNA was extracted from blood 
      tissue of 31 patients and 54 controls. The TNF-alpha-1031 polymorphism was evaluated 
      by polymerase chain reaction- confronting two-pair primer (PCR-CTPP) method. In 
      the GAP group, the frequencies of TT, TC and CC genotypes were 35.48%, 61.29 and 
      3.23%, respectively. In controls the frequencies of TT, TC and CC genotypes were 
      22.22%, 72.22%, and 5.56%, respectively. Results of this study showed that there 
      was no significant association between TNF-alpha (-1031 T/C promoter) gene 
      polymorphisms and the risk of generalized aggressive periodontitis disease.
FAU - Darvishi, E
AU  - Darvishi E
AD  - Kermanshah University of Medical Sciences Medical Biology Research Center 
      Kermanshah Iran.
FAU - Aziziaram, Z
AU  - Aziziaram Z
AD  - Kermanshah University of Medical Sciences Medical Biology Research Center 
      Kermanshah Iran.
FAU - Yari, K
AU  - Yari K
AD  - Kermanshah University of Medical Sciences Medical Biology Research Center 
      Kermanshah Iran.
FAU - Bagheri Dehbaghi, M
AU  - Bagheri Dehbaghi M
AD  - Razi University Incubator Zagros Bioidea Company Kermanshah Iran.
FAU - Kahrizi, D
AU  - Kahrizi D
AD  - Kermanshah University of Medical Sciences Medical Biology Research Center 
      Kermanshah Iran.
FAU - Karim, H
AU  - Karim H
AD  - Kermanshah University of Medical Sciences Department of Sexual Medicine, The 
      Rhazes Center for Research in Family Health and Sexual Medicine Kermanshah Iran.
FAU - Vaziri, S
AU  - Vaziri S
AD  - Kermanshah University of Medical Sciences Department of Infectious Diseases 
      Kermanshah Iran.
FAU - Zargooshi, J
AU  - Zargooshi J
AD  - Kermanshah University of Medical Sciences Department of Sexual Medicine, The 
      Rhazes Center for Research in Family Health and Sexual Medicine Kermanshah Iran 
      zargooshi@gmail.com.
FAU - Ghadiri, K
AU  - Ghadiri K
AD  - Kermanshah University of Medical Sciences Nosocomial Infections Research Center 
      Kermanshah Iran.
FAU - Muhammadi, S
AU  - Muhammadi S
AD  - Kermanshah University of Medical Sciences Department of Sexual Medicine, The 
      Rhazes Center for Research in Family Health and Sexual Medicine Kermanshah Iran.
FAU - Kazemi, E
AU  - Kazemi E
AD  - Kermanshah University of Medical Sciences Department of Sexual Medicine, The 
      Rhazes Center for Research in Family Health and Sexual Medicine Kermanshah Iran.
FAU - Moradi, M T
AU  - Moradi MT
AD  - Kermanshah University of Medical Sciences Medical Biology Research Center 
      Kermanshah Iran.
FAU - Shokrinia, M
AU  - Shokrinia M
AD  - Kermanshah-Based, General Department of Taxation Affairs Kermanshah Iran.
FAU - Mohammadi, N
AU  - Mohammadi N
AD  - Kermanshah-Based, General Department of Taxation Affairs Kermanshah Iran.
LA  - eng
PT  - Journal Article
DEP - 20160930
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Aggressive Periodontitis/genetics/metabolism/*pathology
MH  - Alleles
MH  - Case-Control Studies
MH  - DNA/isolation & purification/metabolism
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - Young Adult
EDAT- 2016/10/19 06:00
MHDA- 2017/02/09 06:00
CRDT- 2016/10/19 06:00
PHST- 2016/05/07 00:00 [received]
PHST- 2016/09/13 00:00 [accepted]
PHST- 2016/10/19 06:00 [pubmed]
PHST- 2017/02/09 06:00 [medline]
PHST- 2016/10/19 06:00 [entrez]
PST - epublish
SO  - Cell Mol Biol (Noisy-le-grand). 2016 Sep 30;62(11):63-66.