PMID- 27756763
OWN - NLM
STAT- MEDLINE
DCOM- 20180703
LR  - 20181018
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Linking)
VI  - 27
IP  - 12
DP  - 2017 Dec 1
TI  - Humor Appreciation Involves Parametric and Synchronized Activity in the Medial 
      Prefrontal Cortex and Hippocampus.
PG  - 5579-5591
LID - 10.1093/cercor/bhw325 [doi]
AB  - Humor perception is a ubiquitous phenomenon in human societies. In theories of 
      humor perception, three factors, non-seriousness, social context, and 
      incongruity, have been implicated in humor. In another theory, however, 
      elaboration and reinterpretation of contexts are considered to play a role in 
      eliciting humor. Although the neural correlates of humor appreciation have been 
      investigated using neuroimaging methods, only a few studies have conducted such 
      experiments under natural conditions. In the present study, two functional 
      magnetic resonance imaging experiments, using a comedy movie as a stimulus, were 
      conducted to investigate the neural correlates of humor under natural conditions. 
      The subjects' brain activity was measured while watching and enjoying a movie. In 
      experiment 1, a parametric analysis showed that the medial prefrontal cortex 
      (MPFC) and hippocampus/amygdala had a positive relationship with the subjective 
      rating of funniness. In experiment 2, intersubject correlation was analyzed to 
      investigate synchronized activity across all participants. Signal synchronization 
      that paralleled increased funniness ratings was observed in the MPFC and 
      hippocampus. Thus, it appears that both parametric and synchronized activity in 
      the MPFC and hippocampus are important during humor appreciation. The present 
      study has revealed the brain regions that are predominantly involved in humor 
      sensation under natural condition.
CI  - (c) The Author 2016. Published by Oxford University Press. All rights reserved. For 
      Permissions, please e-mail: journals.permissions@oup.com.
FAU - Iidaka, Tetsuya
AU  - Iidaka T
AD  - Nagoya University, Graduate School of Medicine, Department of Physical and 
      Occupational Therapy, Brain & Mind Research Center, Nagoya, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
SB  - IM
MH  - Auditory Perception/physiology
MH  - Brain Mapping
MH  - Comprehension/physiology
MH  - Female
MH  - Hippocampus/diagnostic imaging/*physiology
MH  - Humans
MH  - Judgment/physiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Motion Pictures
MH  - Prefrontal Cortex/diagnostic imaging/*physiology
MH  - Reaction Time
MH  - Regression Analysis
MH  - Visual Perception/physiology
MH  - *Wit and Humor as Topic
MH  - Young Adult
OTO - NOTNLM
OT  - amusement
OT  - emotion
OT  - empathy
OT  - frontal pole
OT  - movie
EDAT- 2016/11/01 06:00
MHDA- 2018/07/04 06:00
CRDT- 2016/11/01 06:00
PHST- 2016/05/19 00:00 [received]
PHST- 2016/11/01 06:00 [pubmed]
PHST- 2018/07/04 06:00 [medline]
PHST- 2016/11/01 06:00 [entrez]
AID - bhw325 [pii]
AID - 10.1093/cercor/bhw325 [doi]
PST - ppublish
SO  - Cereb Cortex. 2017 Dec 1;27(12):5579-5591. doi: 10.1093/cercor/bhw325.