PMID- 27757133
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1738-3684 (Print)
IS  - 1976-3026 (Electronic)
IS  - 1738-3684 (Linking)
VI  - 13
IP  - 5
DP  - 2016 Sep
TI  - Chemokine and Chemokine Receptor Polymorphisms in Bipolar Disorder.
PG  - 541-548
AB  - OBJECTIVE: Bipolar disorder (BD) is a debilitating psychiatric disease with 
      unknown etiology. Recent studies have shown inflammation as a potential 
      contributing factor of BD pathogenesis. However, potential associations between 
      chemokine and chemokine receptor polymorphisms and BD have been fundamentally 
      understudied. To identify participation of chemokines in BD pathogenesis, we 
      examined genetic variants of several chemokine and chemokine receptor genes. 
      METHODS: The study population comprised 200 patients with BD and 195 age- and 
      sex-matched healthy controls. Genotyping of monocyte chemotactic protein 1 
      (MCP-1) A2518G, CCR2 V64I, CCR5 Delta32, CCR5 A55029G, stromal cell-derived factor 1 
      (SDF-1) 3'A, and CXCR4 C138T polymorphisms was performed using polymerase chain 
      reaction and restriction enzyme digestion. RESULTS: We found that CCR5-Delta32 II and 
      CXCR4-C138T C+ genotype frequencies contributed to an increased risk for BD. 
      However, no statistical significance could be obtained with these genotypes after 
      Bonferroni correction. A significant asssociation was only found with MCP-1 GG 
      and G+ genotypes, which were markedly more prevalent in patients with BD and 
      these genotypes seemed to significantly increase the risk for BD even after 
      Bonferroni correction. CONCLUSION: Our findings indicate an association between 
      genetic variants of certain chemokine and chemokine receptor (especially MCP-1) 
      genes and BD. The exact mechanisms by which these variants contribute to BD 
      pathogenesis and their clinical implications need to be further investigated.
FAU - Tokac, Damla
AU  - Tokac D
AD  - Department of Neurology, Istanbul Erenkoy Psychiatric and Neurological Disorders 
      Hospital, Istanbul, Turkey.
FAU - Tuzun, Erdem
AU  - Tuzun E
AD  - Department of Neuroscience, Institute of Experimental Medicine, Istanbul 
      University, Istanbul, Turkey.
FAU - Gulec, Huseyin
AU  - Gulec H
AD  - Department of Neurology, Istanbul Erenkoy Psychiatric and Neurological Disorders 
      Hospital, Istanbul, Turkey.
FAU - Yilmaz, Vuslat
AU  - Yilmaz V
AD  - Department of Neuroscience, Institute of Experimental Medicine, Istanbul 
      University, Istanbul, Turkey.
FAU - Bireller, Elif Sinem
AU  - Bireller ES
AD  - Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul Yeni 
      Yuzyil University, Istanbul, Turkey.
FAU - Cakmakoglu, Bedia
AU  - Cakmakoglu B
AD  - Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul 
      University, Istanbul, Turkey.
FAU - Kucukali, Cem Ismail
AU  - Kucukali CI
AD  - Department of Neuroscience, Institute of Experimental Medicine, Istanbul 
      University, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20160930
PL  - Korea (South)
TA  - Psychiatry Investig
JT  - Psychiatry investigation
JID - 101242994
PMC - PMC5067349
OTO - NOTNLM
OT  - Bipolar disorder
OT  - Chemokine
OT  - Chemokine receptor polymorphisms
OT  - Pathogenesis
EDAT- 2016/10/21 06:00
MHDA- 2016/10/21 06:01
PMCR- 2016/09/01
CRDT- 2016/10/21 06:00
PHST- 2015/08/05 00:00 [received]
PHST- 2016/01/26 00:00 [revised]
PHST- 2016/02/12 00:00 [accepted]
PHST- 2016/10/21 06:00 [pubmed]
PHST- 2016/10/21 06:01 [medline]
PHST- 2016/10/21 06:00 [entrez]
PHST- 2016/09/01 00:00 [pmc-release]
AID - 10.4306/pi.2016.13.5.541 [doi]
PST - ppublish
SO  - Psychiatry Investig. 2016 Sep;13(5):541-548. doi: 10.4306/pi.2016.13.5.541. Epub 
      2016 Sep 30.