PMID- 27759902
OWN - NLM
STAT- MEDLINE
DCOM- 20171011
LR  - 20171011
IS  - 1601-0825 (Electronic)
IS  - 1354-523X (Linking)
VI  - 23
IP  - 2
DP  - 2017 Mar
TI  - Histopathologic features in actinic cheilitis by the comparison of grading 
      dysplasia systems.
PG  - 219-224
LID - 10.1111/odi.12597 [doi]
AB  - OBJECTIVE: This study aimed to determine the histopathologic findings in actinic 
      cheilitis (AC) and lip squamous cell carcinomas (LSCC) diagnosed at Federal 
      University of Santa Catarina in order to attempt to predict the evolution from AC 
      to LSCC based on the comparison of two dysplasia classification systems. METHODS: 
      Histopathologic features were evaluated according to the World Health 
      Organization classification of dysplasia and binary system of classification. 
      Also, in LSCC, pattern, stage of invasion, and degree of keratinization were 
      evaluated. A total of 58 cases of AC and 70 cases of LSCC were studied, and data 
      correlation was performed using statistical analysis. RESULTS: The presence of 
      dyskeratosis and keratin pearls was found to be strongly associated with severe 
      dysplasia and could represent higher proximity between the severe dysplasia in AC 
      and LSCC. Also, changes related to the nuclei, such as hyperchromasia, nuclear 
      pleomorphism, anisonucleosis, increase in the number and size of nucleoli, 
      increased number of mitoses, and atypical mitoses, indicate progression in 
      dysplasia spectrum. CONCLUSION: Knowledge of clinical and histological features 
      of AC and LSCC leads to better understanding of factors possibly associated with 
      malignant transformation of epithelial dysplasia.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Pilati, Sfm
AU  - Pilati S
AD  - Odontology, Health Sciences Center, Vale do Itajai University, Itajai, Brazil.
FAU - Bianco, B C
AU  - Bianco BC
AD  - Odontology, Health Sciences Center, Vale do Itajai University, Itajai, Brazil.
FAU - Vieira, Dsc
AU  - Vieira D
AD  - Anatomical Pathology Service, Department of Pathology, Federal University of 
      Santa Catarina, Florianopolis, Brazil.
FAU - Modolo, F
AU  - Modolo F
AD  - Oral Pathology Laboratory, Department of Pathology, Federal University of Santa 
      Catarina, Florianopolis, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20161128
PL  - Denmark
TA  - Oral Dis
JT  - Oral diseases
JID - 9508565
RN  - Actinic cheilitis
MH  - Carcinoma, Squamous Cell/*pathology
MH  - Cell Nucleolus/pathology
MH  - Cell Nucleus/pathology
MH  - Cell Transformation, Neoplastic
MH  - Cheilitis/classification/*pathology
MH  - Humans
MH  - Lip Neoplasms/*pathology
MH  - Mitotic Index
MH  - Neoplasm Staging
OTO - NOTNLM
OT  - World Health Organization
OT  - actinic cheilitis
OT  - binary
OT  - classification
OT  - epithelial dysplasia
OT  - squamous cell carcinoma
EDAT- 2016/10/21 06:00
MHDA- 2017/10/12 06:00
CRDT- 2016/10/21 06:00
PHST- 2016/08/16 00:00 [received]
PHST- 2016/10/03 00:00 [revised]
PHST- 2016/10/13 00:00 [accepted]
PHST- 2016/10/21 06:00 [pubmed]
PHST- 2017/10/12 06:00 [medline]
PHST- 2016/10/21 06:00 [entrez]
AID - 10.1111/odi.12597 [doi]
PST - ppublish
SO  - Oral Dis. 2017 Mar;23(2):219-224. doi: 10.1111/odi.12597. Epub 2016 Nov 28.