PMID- 27760262
OWN - NLM
STAT- MEDLINE
DCOM- 20170526
LR  - 20220331
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 57
IP  - 13
DP  - 2016 Oct 1
TI  - Associations Between Retinal Pigment Epithelium and Drusen Volume Changes During 
      the Lifecycle of Large Drusenoid Pigment Epithelial Detachments.
PG  - 5479-5489
LID - 10.1167/iovs.16-19816 [doi]
AB  - PURPOSE: Drusenoid pigment epithelial detachments (PEDs) are a defined path to 
      atrophy in age-related macular degeneration (AMD). We analyzed the relationships 
      between retinal pigment epithelium (RPE) and drusen volume changes during the PED 
      lifecycle, using spectral-domain optical coherence tomography (SD-OCT). METHODS: 
      Twenty-one cases of drusenoid PED tracked using SD-OCT through periods of growth 
      and collapse were evaluated. Volumetric calculations and piece-wise linear 
      regression analysis were used to determine the breakpoint between growth and 
      collapse. Spectral-domain OCT scans were independently evaluated for the 
      appearance of intraretinal hyperreflective foci, acquired vitelliform lesions 
      (AVLs), and disruptions to the RPE+basal lamina band. Timing of these events with 
      respect to the breakpoint was statistically evaluated. Morphometric 
      characteristics of drusenoid PEDs were correlated with rate of PED collapse and 
      final visual acuity. RESULTS: Mean age of subjects was 75.3 years and mean period 
      of follow up was 4.1 years (median 4.5 years; range, 0.6-6.6 years). The 
      lifecycle of drusenoid PEDs was asymmetric, in that the rate of collapse (0.199 
      mm3/month) is significantly faster (P < 0.001) than the rate of growth (0.022 
      mm3/month). Appearance of intraretinal hyperreflective foci and AVLs preceded the 
      breakpoint (both P < 0.001). The timing of disruptions to the RPE+basal lamina 
      band did not differ from the breakpoint (P = 0.510). Maximal height, volume, and 
      diameter of drusenoid PEDs were inversely correlated with final visual acuity 
      (all P < 0.001) and positively correlated with the rate of PED collapse (all P < 
      0.001). CONCLUSIONS: Spectral-domain OCT signatures, plausibly attributable to 
      anteriorly migrated RPE and disintegration of the RPE layer, precede or occur 
      simultaneously with changes in volume of drusenoid PED during the lifecycle of 
      this lesion.
FAU - Balaratnasingam, Chandrakumar
AU  - Balaratnasingam C
AD  - LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat 
      Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants 
      of New York, New York, United States 3Department of Ophthalmology, New York 
      University School of Medicine, New York, New York, United States 4Department of 
      Physiology and Pharmacology, Centre for Ophthalmology and Visual Science, Lions 
      Eye Institute, University of Western Australia, Perth, Australia.
FAU - Yannuzzi, Lawrence A
AU  - Yannuzzi LA
AD  - LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat 
      Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants 
      of New York, New York, United States.
FAU - Curcio, Christine A
AU  - Curcio CA
AD  - Department of Ophthalmology, University of Alabama School of Medicine, 
      Birmingham, Alabama, United States.
FAU - Morgan, William H
AU  - Morgan WH
AD  - Department of Ophthalmology, New York University School of Medicine, New York, 
      New York, United States.
FAU - Querques, Giuseppe
AU  - Querques G
AD  - Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris 
      Est Creteil, Creteil, France 7Department of Ophthalmology, IRCCS San Raffaele 
      Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy.
FAU - Capuano, Vittorio
AU  - Capuano V
AD  - Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris 
      Est Creteil, Creteil, France.
FAU - Souied, Eric
AU  - Souied E
AD  - Department of Ophthalmology, Hospital Intercommunal de Creteil, University Paris 
      Est Creteil, Creteil, France 7Department of Ophthalmology, IRCCS San Raffaele 
      Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy.
FAU - Jung, Jesse
AU  - Jung J
AD  - LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat 
      Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants 
      of New York, New York, United States 8East Bay Retina Consultants, Inc., Oakland, 
      California, United States.
FAU - Freund, K Bailey
AU  - Freund KB
AD  - LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat 
      Hospital, New York, New York, United States 2Vitreous-Retina-Macula Consultants 
      of New York, New York, United States 3Department of Ophthalmology, New York 
      University School of Medicine, New York, New York, United States.
LA  - eng
GR  - R01 EY006109/EY/NEI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease Progression
MH  - Female
MH  - Fluorescein Angiography
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retinal Detachment/*diagnosis/etiology
MH  - Retinal Drusen/complications/*diagnosis
MH  - Retinal Pigment Epithelium/*pathology
MH  - Retrospective Studies
MH  - Time Factors
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
PMC - PMC5072538
EDAT- 2016/10/21 06:00
MHDA- 2017/05/27 06:00
PMCR- 2016/10/01
CRDT- 2016/10/21 06:00
PHST- 2016/10/21 06:00 [pubmed]
PHST- 2017/05/27 06:00 [medline]
PHST- 2016/10/21 06:00 [entrez]
PHST- 2016/10/01 00:00 [pmc-release]
AID - 2571542 [pii]
AID - IOVS-16-19816 [pii]
AID - 10.1167/iovs.16-19816 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5479-5489. doi: 
      10.1167/iovs.16-19816.