PMID- 27760337
OWN - NLM
STAT- MEDLINE
DCOM- 20170905
LR  - 20181113
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 45
IP  - 4
DP  - 2016 Oct 18
TI  - Functions of Murine Dendritic Cells.
PG  - 719-736
LID - S1074-7613(16)30400-9 [pii]
LID - 10.1016/j.immuni.2016.10.010 [doi]
AB  - Dendritic cells (DCs) play critical roles in activating innate immune cells and 
      initiating adaptive immune responses. The functions of DCs were originally 
      obscured by their overlap with other mononuclear phagocytes, but new mouse models 
      have allowed for the selective ablation of subsets of DCs and have helped to 
      identify their non-redundant roles in the immune system. These tools have 
      elucidated the functions of DCs in host defense against pathogens, autoimmunity, 
      and cancer. This review will describe the mouse models generated to interrogate 
      the role of DCs and will discuss how their use has progressively clarified our 
      understanding of the unique functions of DC subsets.
CI  - Copyright (c) 2016. Published by Elsevier Inc.
FAU - Durai, Vivek
AU  - Durai V
AD  - Department of Pathology and Immunology, Washington University School of Medicine, 
      St. Louis, MO 63110, USA. Electronic address: duraiv@wustl.edu.
FAU - Murphy, Kenneth M
AU  - Murphy KM
AD  - Department of Pathology and Immunology, Washington University School of Medicine, 
      St. Louis, MO 63110, USA; Howard Hughes Medical Institute, Washington University 
      School of Medicine, St. Louis, MO 63110, USA. Electronic address: 
      kmurphy@wustl.edu.
LA  - eng
GR  - F30 DK108498/DK/NIDDK NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - R01 AI049653/AI/NIAID NIH HHS/United States
GR  - P30 CA091842/CA/NCI NIH HHS/United States
GR  - UL1 TR000448/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
SB  - IM
MH  - Adaptive Immunity/immunology
MH  - Animals
MH  - Autoimmunity/immunology/physiology
MH  - Dendritic Cells/*immunology/*physiology
MH  - Humans
MH  - Immunity, Innate/immunology
MH  - Mice
PMC - PMC5145312
MID - NIHMS830718
EDAT- 2016/10/21 06:00
MHDA- 2017/09/07 06:00
PMCR- 2017/10/18
CRDT- 2016/10/21 06:00
PHST- 2016/09/06 00:00 [received]
PHST- 2016/10/21 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
PHST- 2016/10/21 06:00 [entrez]
PHST- 2017/10/18 00:00 [pmc-release]
AID - S1074-7613(16)30400-9 [pii]
AID - 10.1016/j.immuni.2016.10.010 [doi]
PST - ppublish
SO  - Immunity. 2016 Oct 18;45(4):719-736. doi: 10.1016/j.immuni.2016.10.010.