PMID- 27760342
OWN - NLM
STAT- MEDLINE
DCOM- 20170905
LR  - 20181113
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 45
IP  - 4
DP  - 2016 Oct 18
TI  - Antiviral CD8(+) T Cells Restricted by Human Leukocyte Antigen Class II Exist 
      during Natural HIV Infection and Exhibit Clonal Expansion.
PG  - 917-930
LID - S1074-7613(16)30384-3 [pii]
LID - 10.1016/j.immuni.2016.09.015 [doi]
AB  - CD8(+) T cell recognition of virus-infected cells is characteristically 
      restricted by major histocompatibility complex (MHC) class I, although rare 
      examples of MHC class II restriction have been reported in Cd4-deficient mice and 
      a macaque SIV vaccine trial using a recombinant cytomegalovirus vector. Here, we 
      demonstrate the presence of human leukocyte antigen (HLA) class II-restricted 
      CD8(+) T cell responses with antiviral properties in a small subset of 
      HIV-infected individuals. In these individuals, T cell receptor beta (TCRbeta) analysis 
      revealed that class II-restricted CD8(+) T cells underwent clonal expansion and 
      mediated killing of HIV-infected cells. In one case, these cells comprised 12% of 
      circulating CD8(+) T cells, and TCRalpha analysis revealed two distinct co-expressed 
      TCRalpha chains, with only one contributing to binding of the class II HLA-peptide 
      complex. These data indicate that class II-restricted CD8(+) T cell responses can 
      exist in a chronic human viral infection, and may contribute to immune control.
CI  - Copyright (c) 2016 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Ranasinghe, Srinika
AU  - Ranasinghe S
AD  - Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 01239, USA. Electronic 
      address: sranasinghe@mgh.harvard.edu.
FAU - Lamothe, Pedro A
AU  - Lamothe PA
AD  - Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 01239, USA; Harvard T.H. 
      Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Howard 
      Hughes Medical Institute, Chevy Chase, MD 20815, USA.
FAU - Soghoian, Damien Z
AU  - Soghoian DZ
AD  - Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 01239, USA.
FAU - Kazer, Samuel W
AU  - Kazer SW
AD  - Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 01239, USA; Institute for 
      Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, 
      MA 01239, USA; Broad Institute, Cambridge, MA 01239, USA.
FAU - Cole, Michael B
AU  - Cole MB
AD  - Department of Physics, University of California, Berkeley, CA 94720, USA.
FAU - Shalek, Alex K
AU  - Shalek AK
AD  - Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 01239, USA; Institute for 
      Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, 
      MA 01239, USA; Broad Institute, Cambridge, MA 01239, USA.
FAU - Yosef, Nir
AU  - Yosef N
AD  - Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 01239, USA; Department of 
      Physics, University of California, Berkeley, CA 94720, USA.
FAU - Jones, R Brad
AU  - Jones RB
AD  - Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 01239, USA; George 
      Washington University, Washington, DC 20052, USA.
FAU - Donaghey, Faith
AU  - Donaghey F
AD  - Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 01239, USA.
FAU - Nwonu, Chioma
AU  - Nwonu C
AD  - Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 01239, USA.
FAU - Jani, Priya
AU  - Jani P
AD  - Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 01239, USA.
FAU - Clayton, Gina M
AU  - Clayton GM
AD  - Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of 
      Biomedical Research, National Jewish Health, Denver, CO 80206, USA.
FAU - Crawford, Frances
AU  - Crawford F
AD  - Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of 
      Biomedical Research, National Jewish Health, Denver, CO 80206, USA.
FAU - White, Janice
AU  - White J
AD  - Department of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.
FAU - Montoya, Alana
AU  - Montoya A
AD  - Department of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.
FAU - Power, Karen
AU  - Power K
AD  - Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 01239, USA.
FAU - Allen, Todd M
AU  - Allen TM
AD  - Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 01239, USA.
FAU - Streeck, Hendrik
AU  - Streeck H
AD  - Institute for HIV Research, University Hospital, University Duisburg-Essen, Essen 
      45147, Germany; U.S. Military HIV Research Program, Henry M. Jackson Foundation, 
      Rockville, MD 20910, USA.
FAU - Kaufmann, Daniel E
AU  - Kaufmann DE
AD  - Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 01239, USA; Centre de 
      Recherche du Centre hospitalier de l'Universite de Montreal, Montreal, QC H2X 
      3J4, Canada.
FAU - Picker, Louis J
AU  - Picker LJ
AD  - Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, 
      Oregon Health & Science University, Beaverton, OR 97006, USA.
FAU - Kappler, John W
AU  - Kappler JW
AD  - Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of 
      Biomedical Research, National Jewish Health, Denver, CO 80206, USA.
FAU - Walker, Bruce D
AU  - Walker BD
AD  - Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 01239, USA; Harvard T.H. 
      Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Howard 
      Hughes Medical Institute, Chevy Chase, MD 20815, USA; Institute for Medical 
      Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 
      01239, USA; Broad Institute, Cambridge, MA 01239, USA. Electronic address: 
      bwalker@mgh.harvard.edu.
LA  - eng
GR  - DP2 GM119419/GM/NIGMS NIH HHS/United States
GR  - P01 AI104715/AI/NIAID NIH HHS/United States
GR  - U24 AI118672/AI/NIAID NIH HHS/United States
GR  - R21 AI125085/AI/NIAID NIH HHS/United States
GR  - P30 AI060354/AI/NIAID NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Antiviral Agents)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
SB  - IM
CIN - Immunity. 2016 Oct 18;45(4):712-714. PMID: 27760334
MH  - Antiviral Agents/*immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - HIV Infections/*immunology
MH  - HLA Antigens/immunology
MH  - Histocompatibility Antigens Class II/*immunology
MH  - Humans
MH  - Receptors, Antigen, T-Cell, alpha-beta/*immunology
PMC - PMC5077698
OTO - NOTNLM
OT  - CD8(+) T cells
OT  - HIV
OT  - HLA
OT  - MHC class II
OT  - TCR
OT  - vaccines
EDAT- 2016/10/21 06:00
MHDA- 2017/09/07 06:00
PMCR- 2016/10/18
CRDT- 2016/10/21 06:00
PHST- 2016/06/03 00:00 [received]
PHST- 2016/08/09 00:00 [revised]
PHST- 2016/08/15 00:00 [accepted]
PHST- 2016/10/21 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
PHST- 2016/10/21 06:00 [entrez]
PHST- 2016/10/18 00:00 [pmc-release]
AID - S1074-7613(16)30384-3 [pii]
AID - 10.1016/j.immuni.2016.09.015 [doi]
PST - ppublish
SO  - Immunity. 2016 Oct 18;45(4):917-930. doi: 10.1016/j.immuni.2016.09.015.