PMID- 27760732
OWN - NLM
STAT- MEDLINE
DCOM- 20170626
LR  - 20200930
IS  - 1522-1490 (Electronic)
IS  - 0363-6119 (Linking)
VI  - 311
IP  - 6
DP  - 2016 Dec 1
TI  - Maternal vascular responses to hypoxia in a rat model of intrauterine growth 
      restriction.
PG  - R1068-R1075
LID - 10.1152/ajpregu.00119.2016 [doi]
AB  - Intrauterine growth restriction (IUGR) is a common pregnancy complication and is 
      a leading cause of fetal morbidity and mortality. Placental hypoxia contributes 
      to adverse fetal consequences, such as IUGR. Exposing pregnant rats to hypoxia 
      can lead to IUGR; however, assessment of maternal vascular function in a rat 
      model of hypoxia, and the mechanisms that may contribute to adverse pregnancy 
      outcomes, has not been extensively studied. We hypothesized that exposing 
      pregnant rats to hypoxia will affect maternal systemic vascular function and 
      increase the uterine artery resistance index (RI), which will be associated with 
      IUGR. To test this hypothesis, pregnant rats were kept in normoxia (21% O(2)) or 
      hypoxia (11% O(2)) from gestational day (GD) 6 to 20 Maternal blood pressure, 
      uteroplacental resistance index (RI) (ultrasound biomicroscopy), and vascular 
      function (wire myography) were assessed in uterine and mesenteric arteries. Fetal 
      weight was significantly reduced (P < 0.001), while maternal blood pressure was 
      increased (P < 0.05) in rats exposed to hypoxia. Maternal vascular function was 
      also affected after exposure to hypoxia, including impaired endothelium-dependent 
      vasodilation responses to methacholine in isolated uterine arteries (pEC(50) 
      normoxia: 6.55 +/- 0.23 vs. hypoxia: 5.02 +/- 0.35, P < 0.01) and a reduced uterine 
      artery RI in vivo (normoxia: 0.63 +/- 0.04 vs. hypoxia: 0.53 +/- 0.01, P < 0.05); 
      associated with an increase in umbilical vein RI (normoxia: 0.35 +/- 0.02 vs. 
      hypoxia: 0.45 +/- 0.04, P < 0.05). These data demonstrate maternal and fetal 
      alterations in vascular function due to prenatal exposure to hypoxia. Further, 
      although there was a compensatory reduction in uterine artery RI in the hypoxia 
      groups, this was not sufficient to prevent IUGR.
CI  - Copyright (c) 2016 the American Physiological Society.
FAU - Aljunaidy, Mais M
AU  - Aljunaidy MM
AD  - Department of Obstetrics and Gynecology, University of Alberta, Alberta, 
      Edmonton, Canada.
AD  - Department of Physiology, University of Alberta, Alberta, Edmonton, Canada; and.
AD  - Women and Children's Health Research Institute and the Cardiovascular Research 
      Centre, Edmonton, Alberta, Canada.
FAU - Morton, Jude S
AU  - Morton JS
AD  - Department of Obstetrics and Gynecology, University of Alberta, Alberta, 
      Edmonton, Canada.
AD  - Women and Children's Health Research Institute and the Cardiovascular Research 
      Centre, Edmonton, Alberta, Canada.
FAU - Cooke, Christy-Lynn
AU  - Cooke CL
AD  - Department of Obstetrics and Gynecology, University of Alberta, Alberta, 
      Edmonton, Canada.
AD  - Women and Children's Health Research Institute and the Cardiovascular Research 
      Centre, Edmonton, Alberta, Canada.
FAU - Davidge, Sandra T
AU  - Davidge ST
AD  - Department of Obstetrics and Gynecology, University of Alberta, Alberta, 
      Edmonton, Canada; sandra.davidge@ualberta.ca.
AD  - Department of Physiology, University of Alberta, Alberta, Edmonton, Canada; and.
AD  - Women and Children's Health Research Institute and the Cardiovascular Research 
      Centre, Edmonton, Alberta, Canada.
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161019
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
SB  - IM
MH  - Animals
MH  - Blood Flow Velocity
MH  - Blood Pressure
MH  - Female
MH  - Fetal Growth Retardation/*physiopathology
MH  - Hypoxia/*physiopathology
MH  - Male
MH  - Mesenteric Arteries/*physiopathology
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/*physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Uterine Artery/*physiopathology
MH  - Vascular Resistance
OTO - NOTNLM
OT  - hypoxia
OT  - intrauterine growth restriction
OT  - ultrasonography
OT  - uterine artery
OT  - wire myography
EDAT- 2016/10/21 06:00
MHDA- 2017/06/27 06:00
CRDT- 2016/10/21 06:00
PHST- 2016/03/25 00:00 [received]
PHST- 2016/10/06 00:00 [revised]
PHST- 2016/10/12 00:00 [accepted]
PHST- 2016/10/21 06:00 [pubmed]
PHST- 2017/06/27 06:00 [medline]
PHST- 2016/10/21 06:00 [entrez]
AID - ajpregu.00119.2016 [pii]
AID - 10.1152/ajpregu.00119.2016 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1068-R1075. doi: 
      10.1152/ajpregu.00119.2016. Epub 2016 Oct 19.