PMID- 27761078
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 0973-1296 (Print)
IS  - 0976-4062 (Electronic)
IS  - 0973-1296 (Linking)
VI  - 12
IP  - Suppl 4
DP  - 2016 Jul
TI  - Postprandial Antihyperglycemic And Antioxidant Activities of Acalypha indica Linn 
      Stem Extract: An In-vivo Study.
PG  - S475-S481
AB  - BACKGROUND: alpha-glucosidase inhibitors controls postprandial hyperglycemia (PPHG) 
      by lowering sharp rise in blood glucose levels after ingestion of carbohydrate 
      rich meal in type 2 diabetic (T2D) individuals. Acalypha indica commonly known as 
      Indian copper leaf is used in traditional medicinal system to treat various 
      diseases. In our previous in-vitro investigation, methanolic extract of A. indica 
      stems (AIS) proved to be an effective a-glucosidase inhibitor, antioxidant, and 
      well tolerated in acute and subchronic toxicity studies in albino wistar rats. 
      OBJECTIVE: In this perspective, this study was designed to evaluate postprandial 
      antihyperglycemic potential of AIS in maltose, sucrose, and glucose loaded 
      streptozotocin (STZ)-induced normal and diabetic rats. As, the acute 
      hyperglycemia at postprandial period has more triggering effect on oxidative 
      stress, study was also aimed to evaluate the antioxidant potential of AIS on 
      STZ-induced Albino-Wistar rats. MATERIALS AND METHODS: Rats were treated with AIS 
      (300-600 mg/kg b.w.) to investigate effect of AIS in controling PPHG after 
      carbohydrate loading. Hepatoprotective activity of AIS is evaluated in diabetic 
      rats by treating them at the dosages 300-600 mg/kg b.w. RESULTS: Studies revealed 
      69.10 and 80.35% blood glucose-lowering effect of AIS in maltose and sucrose 
      loaded diabetic rats in comparison with the diabetic control group. AIS recovered 
      the liver damage caused by streptozotocin. CONCLUSION: The present study 
      confirmed high potential of AIS in controling PPHG by inhibiting a-glucosidase 
      enzyme in maltose and sucrose loaded diabetic rats. AIS also exhibited 
      hepatoprotective activity in STZ-induced diabetic rats. Thus, AIS could be used 
      as a nutraceutical supplement to treat T2D effectively. SUMMARY: AIS extract is 
      effective in suppressing maltose and sucrose-induced postprandial hyperglycemic 
      spikes in ratsAIS treat ment showed a 69.10 and80.35% blood glucose-lowering 
      effect in maltose and sucrose loaded diabetic rats in comparison with the 
      diabetic control group.AIS also improved the antioxidant status in diabetic rats 
      and also has recovered the liver damage caused by streptozotocin.The 
      alpha-glucosidase inhibitor isolated from AIS is a good supplement to control 
      postprandial blood glucose level in the management of type 2 diabetes. 
      Abbreviations used: AIS: Acalypha indica Stems, ALP: Alkaline Phosphatase, b/w: 
      Body Weight, PPHG: Postprandial hyperglycemia, SE: Standard Error, SGOT: Serum 
      glutamate oxaloacetate transaminase, SGPT: Serum glutamate pyruvate transaminase, 
      SOD: Superoxide dismutase, STZ: Streptozotocin, TB: Total Bilirubin, T2D: Type 2 
      diabetes.
FAU - Priya, Charles Lekhya
AU  - Priya CL
AD  - Molecular and Microbiology Research Laboratory, Environmental Biotechnology 
      Division, School of Bio Sciences and Technology, VIT University, Vellore, Tamil 
      Nadu, India.
FAU - Bhaskara Rao, K V
AU  - Bhaskara Rao KV
AD  - Molecular and Microbiology Research Laboratory, Environmental Biotechnology 
      Division, School of Bio Sciences and Technology, VIT University, Vellore, Tamil 
      Nadu, India.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacogn Mag
JT  - Pharmacognosy magazine
JID - 101300403
PMC - PMC5068127
OTO - NOTNLM
OT  - Acalypha indica
OT  - Albino-Wistar rats
OT  - a-glucosidase inhibitor
OT  - antioxidant
OT  - postprandial hyperglycemia
EDAT- 2016/10/21 06:00
MHDA- 2016/10/21 06:01
PMCR- 2016/07/01
CRDT- 2016/10/21 06:00
PHST- 2016/10/21 06:00 [pubmed]
PHST- 2016/10/21 06:01 [medline]
PHST- 2016/10/21 06:00 [entrez]
PHST- 2016/07/01 00:00 [pmc-release]
AID - PM-12-475 [pii]
AID - 10.4103/0973-1296.191461 [doi]
PST - ppublish
SO  - Pharmacogn Mag. 2016 Jul;12(Suppl 4):S475-S481. doi: 10.4103/0973-1296.191461.