PMID- 27761143
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220317
IS  - 1726-913X (Print)
IS  - 1726-9148 (Electronic)
IS  - 1726-913X (Linking)
VI  - 14
IP  - 2
DP  - 2016 Apr
TI  - Altered Concentrations of Copper, Zinc, and Iron are Associated With Increased 
      Levels of Glycated Hemoglobin in Patients With Type 2 Diabetes Mellitus and Their 
      First-Degree Relatives.
PG  - e33273
LID - e33273
AB  - BACKGROUND: The altered levels of some essential trace elements and antioxidant 
      minerals have been observed in diabetic patients. OBJECTIVES: The aim of the 
      present study was to compare the concentrations of essential trace elements, 
      copper (Cu), zinc (Zn), and iron (Fe) in the serum of patients who have type 2 
      diabetes mellitus (T2DM) with those of their non-diabetic first-degree relatives 
      (FDR) and control subjects. The association between glycated hemoglobin (HbA1c) 
      and levels of metals was also evaluated. PATIENTS AND METHODS: We studied 46 
      subjects with T2DM, 46 FDR, and 50 control subjects matched for age and sex. 
      Serum concentrations of Cu, Zn, and Fe were measured by colorimetric kit. Fasting 
      blood glucose (FBG) and HbA1c were assayed using the standard kit. RESULTS: An 
      imbalance in the levels of the studied metals was observed in both patients with 
      T2DM and FDR. We found significantly decreased levels of Zn and higher levels of 
      Cu and Fe in the patients with T2DM and FDR when compared with the control 
      subjects (P < 0.05). HbA1c levels were positively correlated with Cu and Fe and 
      inversely correlated with Zn in the patients with T2DM and FDR (P < 0.05). 
      CONCLUSIONS: The patients with T2DM and FDR had altered contents of Cu, Zn, and 
      Fe that might be a predisposing factor to the development of diabetes in future 
      or vice versa the result of diabetes development. Impaired metabolism of these 
      elements may contribute to the augmented risk of developing type 2 diabetes 
      mellitus later in the life of their first-degree relatives.
FAU - Atari-Hajipirloo, Somayeh
AU  - Atari-Hajipirloo S
AD  - Department of Biochemistry, Urmia University of Medical Sciences, Urmia, IR Iran.
FAU - Valizadeh, Neda
AU  - Valizadeh N
AD  - Department of Endocrinology and Metabolism, Urmia University of Medical Sciences, 
      Urmia, IR Iran.
FAU - Khadem-Ansari, Mohammad-Hassan
AU  - Khadem-Ansari MH
AD  - Department of Biochemistry, Urmia University of Medical Sciences, Urmia, IR Iran.
FAU - Rasmi, Yousef
AU  - Rasmi Y
AD  - Department of Biochemistry, Faculty of Medicine, Cellular and Molecular Research 
      Center, Urmia University of Medical Sciences, Urmi, IR Iran.
FAU - Kheradmand, Fatemeh
AU  - Kheradmand F
AD  - Department of Biochemistry, Faculty of Medicine, Cellular and Molecular Research 
      Center, Urmia University of Medical Sciences, Urmi, IR Iran.
LA  - eng
PT  - Journal Article
DEP - 20160319
PL  - Netherlands
TA  - Int J Endocrinol Metab
JT  - International journal of endocrinology and metabolism
JID - 101235597
PMC - PMC5055748
OTO - NOTNLM
OT  - Copper
OT  - HbA1c
OT  - Iron
OT  - Relatives
OT  - Type 2 Diabetes Mellitus
OT  - Zinc
EDAT- 2016/10/21 06:00
MHDA- 2016/10/21 06:01
PMCR- 2016/04/01
CRDT- 2016/10/21 06:00
PHST- 2015/09/20 00:00 [received]
PHST- 2016/02/13 00:00 [revised]
PHST- 2016/02/29 00:00 [accepted]
PHST- 2016/10/21 06:00 [pubmed]
PHST- 2016/10/21 06:01 [medline]
PHST- 2016/10/21 06:00 [entrez]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 10.5812/ijem.33273 [doi]
PST - epublish
SO  - Int J Endocrinol Metab. 2016 Mar 19;14(2):e33273. doi: 10.5812/ijem.33273. 
      eCollection 2016 Apr.