PMID- 27765061
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 18
IP  - 1
DP  - 2016 Oct 21
TI  - Cardiovascular magnetic resonance patterns of biopsy proven cardiac involvement 
      in systemic sclerosis.
PG  - 70
LID - 70
AB  - BACKGROUND: To determine morphological and functional cardiovascular magnetic 
      resonance (CMR) patterns in histopathologically confirmed myocardial involvement 
      in patients with systemic sclerosis (SSc). METHODS: Twenty patients (6 females; 
      mean age 41 +/- 11 years) with histopathologically proven cardiac involvement in 
      SSc in the years 2008-2016 were retrospectively evaluated. Morphological, 
      functional and late gadolinium enhancement (LGE) images were acquired in standard 
      angulations at 1.5 T CMR. Pathologies were categorized: 1) Pericardial effusion; 
      2) pathologic left (LV) or right ventricular (RV) contractility (hypokinesia, 
      dyssynchrony, and diastolic restriction); 3) reduced left (LV-EF) and right 
      ventricular ejection fraction (RV-EF); 4) fibrosis and/or inflammation (positive 
      LGE); 5) RV dilatation. 95 % confidence intervals (CI) were calculated for 
      appearance of pathologic EF and RV dilatation. RESULTS: Seven patients (35 %) had 
      positive CMR findings in three categories, 9 patients (45 %) in four categories 
      and 4 patients (20 %) in five categories. The distribution of pathologic findings 
      was: minimal pericardial effusion in 7 patients (35 %), moderate pericardial 
      effusion >5 mm in nine patients (45 %); abnormal LV or RV contractility in 19 
      patients (95 %), reduced LV or RV function in 14 patients (70 %; 95 % CI: 
      51-88 %), pathologic LGE in all patients, RV dilatation in 6 patients (30 %; 95 % 
      CI: 15-54 %). CONCLUSIONS: CMR diagnosis of myocardial involvement in SSc 
      requires increased attention to subtle findings. Pathologic findings in at least 
      three of five categories indicate myocardial involvement in SSc.
FAU - Krumm, Patrick
AU  - Krumm P
AUID- ORCID: 0000-0003-1705-8439
AD  - Department of Radiology, Diagnostic and Interventional Radiology, University of 
      Tubingen, Hoppe-Seyler-Str. 3, Tubingen, 72076, Germany. 
      patrick.krumm@uni-tuebingen.de.
FAU - Mueller, Karin A L
AU  - Mueller KA
AD  - Department of Internal Medicine III, Cardiology and Cardiovascular Medicine, 
      University of Tubingen, Tubingen, Germany.
FAU - Klingel, Karin
AU  - Klingel K
AD  - Department of Pathology and Neuropathology, Molecular Pathology, University of 
      Tubingen, Tubingen, Germany.
FAU - Kramer, Ulrich
AU  - Kramer U
AD  - Department of Radiology, Diagnostic and Interventional Radiology, University of 
      Tubingen, Hoppe-Seyler-Str. 3, Tubingen, 72076, Germany.
FAU - Horger, Marius S
AU  - Horger MS
AD  - Department of Radiology, Diagnostic and Interventional Radiology, University of 
      Tubingen, Hoppe-Seyler-Str. 3, Tubingen, 72076, Germany.
FAU - Zitzelsberger, Tanja
AU  - Zitzelsberger T
AD  - Department of Radiology, Diagnostic and Interventional Radiology, University of 
      Tubingen, Hoppe-Seyler-Str. 3, Tubingen, 72076, Germany.
FAU - Kandolf, Reinhard
AU  - Kandolf R
AD  - Department of Pathology and Neuropathology, Molecular Pathology, University of 
      Tubingen, Tubingen, Germany.
FAU - Gawaz, Meinrad
AU  - Gawaz M
AD  - Department of Internal Medicine III, Cardiology and Cardiovascular Medicine, 
      University of Tubingen, Tubingen, Germany.
FAU - Nikolaou, Konstantin
AU  - Nikolaou K
AD  - Department of Radiology, Diagnostic and Interventional Radiology, University of 
      Tubingen, Hoppe-Seyler-Str. 3, Tubingen, 72076, Germany.
FAU - Klumpp, Bernhard D
AU  - Klumpp BD
AD  - Department of Radiology, Diagnostic and Interventional Radiology, University of 
      Tubingen, Hoppe-Seyler-Str. 3, Tubingen, 72076, Germany.
FAU - Henes, Joerg C
AU  - Henes JC
AD  - Department of Internal Medicine II, Rheumatology, University of Tubingen, 
      Tubingen, Germany.
LA  - eng
PT  - Journal Article
PT  - Video-Audio Media
DEP - 20161021
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Cardiomyopathies/*diagnostic imaging/pathology/physiopathology
MH  - Contrast Media/administration & dosage
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction
MH  - Myocardium/*pathology
MH  - Organometallic Compounds/administration & dosage
MH  - Pericardial Effusion/diagnostic imaging/pathology/physiopathology
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Scleroderma, Systemic/*complications/diagnosis
MH  - Stroke Volume
MH  - Ventricular Dysfunction, Left/diagnostic imaging/pathology/physiopathology
MH  - Ventricular Dysfunction, Right/diagnostic imaging/pathology/physiopathology
MH  - Ventricular Function, Left
MH  - Ventricular Function, Right
PMC - PMC5073418
OTO - NOTNLM
OT  - Cardiomyopathy
OT  - Cardiovascular magnetic resonance
OT  - Rheumatic heart disease
OT  - Systemic sclerosis
EDAT- 2016/10/22 06:00
MHDA- 2017/12/13 06:00
PMCR- 2016/10/21
CRDT- 2016/10/22 06:00
PHST- 2016/07/02 00:00 [received]
PHST- 2016/09/30 00:00 [accepted]
PHST- 2016/10/22 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
PHST- 2016/10/22 06:00 [entrez]
PHST- 2016/10/21 00:00 [pmc-release]
AID - S1097-6647(23)01011-6 [pii]
AID - 289 [pii]
AID - 10.1186/s12968-016-0289-3 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2016 Oct 21;18(1):70. doi: 10.1186/s12968-016-0289-3.