PMID- 27766192
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2196-2979 (Print)
IS  - 2196-2979 (Electronic)
VI  - 3
IP  - 2
DP  - 2016 Jun
TI  - Aerobic Exercise in People with Schizophrenia: Neural and Neurocognitive 
      Benefits.
PG  - 165-175
AB  - Schizophrenia is characterized by extensive neurocognitive deficits, which are 
      linked to greater disability, poorer functional outcome, and have been suggested 
      to impact daily functioning more than clinical symptoms. Aerobic exercise (AE) 
      has emerged as a potential intervention. This review examines the impact of AE on 
      brain structure and function along with neurocognitive performance in individuals 
      with schizophrenia. Preliminary evidence indicates that AE can increase 
      hippocampal volume and cortical thickness, in addition to exerting a 
      neuroprotective effect against hippocampal volume decrease and cortical thinning. 
      There is also evidence that AE is able to significantly increase serum 
      brain-derived neurotrophic factor (BDNF) levels, which are implicated in 
      neurogenesis, neuroplasticity, and cognitive improvement. Finally, evidence 
      suggests that AE plays a significant role in improving overall cognition, 
      including improvements in processing speed, working memory, and visual learning. 
      The authors discuss the implications of the findings and provide recommendations 
      for future research and areas of inquiry.
FAU - Vakhrusheva, Julia
AU  - Vakhrusheva J
AD  - Department of Psychiatry Westchester Division, Weill Cornell Medical College, 
      Outpatient Department, 21 Bloomingdale Road, White Plains, NY 10605, USA.
FAU - Marino, Brielle
AU  - Marino B
AD  - Department of Psychiatry Westchester Division, Weill Cornell Medical College, 
      Outpatient Department, 21 Bloomingdale Road, White Plains, NY 10605, USA.
FAU - Stroup, T Scott
AU  - Stroup TS
AD  - Department of Psychiatry, Columbia University, New York, NY, USA; New York State 
      Psychiatric Institute, New York, NY, USA.
FAU - Kimhy, David
AU  - Kimhy D
AD  - Department of Psychiatry, Columbia University, New York, NY, USA; New York State 
      Psychiatric Institute, New York, NY, USA.
LA  - eng
GR  - R21 MH096132/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20160404
PL  - Switzerland
TA  - Curr Behav Neurosci Rep
JT  - Current behavioral neuroscience reports
JID - 101626570
PMC - PMC5067077
MID - NIHMS791954
OTO - NOTNLM
OT  - Aerobic exercise
OT  - Aerobic fitness
OT  - BDNF
OT  - Brain structure
OT  - Cognition
OT  - Hippocampal volume
OT  - Neuroplasticity
OT  - Neurotrophins
OT  - Schizophrenia
COIS- Dr. Julia Vakhrusheva, Ms. Brielle Marino, and Dr. David Kimhy declare that they 
      have no conflicts of interest. Dr. T. Scott Stroup reports support from Genentech 
      for CME, outside the submitted work.
EDAT- 2016/10/22 06:00
MHDA- 2016/10/22 06:01
PMCR- 2017/06/01
CRDT- 2016/10/22 06:00
PHST- 2016/10/22 06:00 [pubmed]
PHST- 2016/10/22 06:01 [medline]
PHST- 2016/10/22 06:00 [entrez]
PHST- 2017/06/01 00:00 [pmc-release]
AID - 10.1007/s40473-016-0077-2 [doi]
PST - ppublish
SO  - Curr Behav Neurosci Rep. 2016 Jun;3(2):165-175. doi: 10.1007/s40473-016-0077-2. 
      Epub 2016 Apr 4.