PMID- 27766786
OWN - NLM
STAT- MEDLINE
DCOM- 20170317
LR  - 20181113
IS  - 1759-7714 (Electronic)
IS  - 1759-7706 (Print)
IS  - 1759-7706 (Linking)
VI  - 7
IP  - 5
DP  - 2016 Sep
TI  - Cytopathological findings of primary pulmonary Ewing family of tumors with EWSR1 
      translocation: A case report.
PG  - 602-606
LID - 10.1111/1759-7714.12347 [doi]
AB  - Primary pulmonary neoplasms of the Ewing family of tumors (EFT) are extremely 
      rare and usually occur in adolescents or young adults. Only about 40 cases of 
      pulmonary EFT have been reported in English literature, and no cytological 
      studies have been documented. In this report, we describe the cytopathological 
      findings of a primary pulmonary EFT in an elderly patient. A 70-year-old man 
      sought care because of a progressing cough and dyspnea. Chest computed tomography 
      revealed a circumscribed mass of 6 cm in the left upper lobe. Fine needle 
      aspiration cytology and core needle biopsy revealed uniform round cell 
      proliferation. The predominant population consisted of cells with thickened 
      nuclear membranes, finely dispersed chromatin, single distinct nucleoli, and 
      indistinct cytoplasm. The other population consisted of smaller cells with darker 
      chromatin. The cytoplasm stained positive for periodic acid-Schiff stain and was 
      digested by diastase. Immunohistochemistry showed positivity for MIC2 (CD99), and 
      focal positivity for neuron specific enolase, synaptophysin, and chromogranin A. 
      Fluorescence in situ hybridization (FISH) revealed EWSR1 translocation. Although 
      rare, pulmonary EFT cannot be disregarded, regardless of age. When two 
      populations of uniform, round cells are observed, immunohistochemistry with MIC2 
      (CD99) and cytogenetic analysis by reverse transcription polymerase chain 
      reaction or FISH should be considered. Cytological diagnosis may play an 
      important role in the early diagnosis and treatment of pulmonary EFT.
CI  - (c) 2016 The Authors. Thoracic Cancer published by China Lung Oncology Group and 
      John Wiley & Sons Australia, Ltd.
FAU - Mizuguchi, Keishi
AU  - Mizuguchi K
AD  - Department of Pathology, Kansai Electric Power Hospital, Osaka, Japan.
FAU - Minato, Hiroshi
AU  - Minato H
AD  - Department of Pathology and Laboratory Medicine, Kanazawa Medical University, 
      Ishikawa, Japan.
FAU - Onishi, Hitomi
AU  - Onishi H
AD  - Department of Pathology, Kansai Electric Power Hospital, Osaka, Japan.
FAU - Mitani, Yuki
AU  - Mitani Y
AD  - Department of Clinical Laboratory, Japan Community Healthcare Organization 
      Kanazawa Hospital, Ishikawa, Japan.
FAU - Kawai, Jun
AU  - Kawai J
AD  - Department of Pathology, Kansai Electric Power Hospital, Osaka, Japan.
LA  - eng
PT  - Case Reports
DEP - 20160324
PL  - Singapore
TA  - Thorac Cancer
JT  - Thoracic cancer
JID - 101531441
RN  - 0 (Calmodulin-Binding Proteins)
RN  - 0 (EWSR1 protein, human)
RN  - 0 (RNA-Binding Protein EWS)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Aged
MH  - Biopsy, Fine-Needle
MH  - Calmodulin-Binding Proteins/*genetics
MH  - Humans
MH  - Lung Neoplasms/*diagnostic imaging/genetics/pathology
MH  - Male
MH  - RNA-Binding Protein EWS
MH  - RNA-Binding Proteins/*genetics
MH  - Sarcoma, Ewing/*diagnostic imaging/genetics/pathology
MH  - *Translocation, Genetic
PMC - PMC5125323
OTO - NOTNLM
OT  - Aspiration cytology
OT  - EWSR1
OT  - Ewing family of tumors
OT  - elderly man
OT  - lung
EDAT- 2016/10/22 06:00
MHDA- 2017/03/18 06:00
PMCR- 2016/09/01
CRDT- 2016/10/22 06:00
PHST- 2016/01/18 00:00 [received]
PHST- 2016/02/11 00:00 [accepted]
PHST- 2016/10/22 06:00 [pubmed]
PHST- 2017/03/18 06:00 [medline]
PHST- 2016/10/22 06:00 [entrez]
PHST- 2016/09/01 00:00 [pmc-release]
AID - TCA12347 [pii]
AID - 10.1111/1759-7714.12347 [doi]
PST - ppublish
SO  - Thorac Cancer. 2016 Sep;7(5):602-606. doi: 10.1111/1759-7714.12347. Epub 2016 Mar 
      24.