PMID- 27766790
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 2233-6079 (Print)
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Linking)
VI  - 40
IP  - 6
DP  - 2016 Dec
TI  - Risk Factors for the Development and Progression of Diabetic Kidney Disease in 
      Patients with Type 2 Diabetes Mellitus and Advanced Diabetic Retinopathy.
PG  - 473-481
LID - 10.4093/dmj.2016.40.6.473 [doi]
AB  - BACKGROUND: Some patients with type 2 diabetes mellitus (T2DM) do not develop 
      diabetic kidney disease (DKD) despite the presence of advanced diabetic 
      retinopathy (DR). We aimed to investigate the presence of DKD and its risk 
      factors in patients with T2DM and advanced DR. METHODS: We conducted a 
      cross-sectional study in 317 patients with T2DM and advanced DR. The phenotypes 
      of DKD were divided into three groups according to the urine albumin/creatinine 
      ratio (uACR, mg/g) and estimated glomerular filtration rate (eGFR, mL/min/1.73 
      m(2)): no DKD (uACR <30 and eGFR >/=60), non-severe DKD (uACR >/=30 or eGFR <60), and 
      severe DKD (uACR >/=30 and eGFR <60). Mean systolic and diastolic blood pressure, 
      mean glycosylated hemoglobin (HbA1c) level, and HbA1c variability (standard 
      deviation [SD] of serial HbA1c values or HbA1c-SD) were calculated for the 
      preceding 2 years. RESULTS: The prevalence of no DKD, non-severe DKD, and severe 
      DKD was 37.2% (n=118), 37.0% (n=117), and 25.8% (n=82), respectively. HbA1c-SD 
      and the triglyceride/high density lipoprotein cholesterol (TG/HDL-C) ratio 
      correlated positively with uACR and negatively with eGFR. Multiple linear 
      regression analyses showed that the HbA1c-SD and TG/HDL-C ratio were 
      significantly related with eGFR. Multiple logistic regression analyses after 
      adjusting for several risk factors showed that HbA1c-SD and the TG/HDL-C ratio 
      were significant risk factors for severe DKD. CONCLUSION: The prevalence of DKD 
      was about 60% in patients with T2DM and advanced DR. HbA1c variability and 
      TG/HDL-C ratio may affect the development and progression of DKD in these 
      patients.
FAU - Yun, Kyung Jin
AU  - Yun KJ
AD  - Department of Internal Medicine, Yeouido St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Kim, Hye Ji
AU  - Kim HJ
AD  - Department of Internal Medicine, Yeouido St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Kim, Mee Kyoung
AU  - Kim MK
AD  - Department of Internal Medicine, Yeouido St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Kwon, Hyuk Sang
AU  - Kwon HS
AD  - Department of Internal Medicine, Yeouido St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Baek, Ki Hyun
AU  - Baek KH
AD  - Department of Internal Medicine, Yeouido St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Roh, Young Jung
AU  - Roh YJ
AD  - Department of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, 
      The Catholic University of Korea, Seoul, Korea.
FAU - Song, Ki Ho
AU  - Song KH
AUID- ORCID: 0000-0003-1883-7039
AD  - Department of Internal Medicine, Yeouido St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea. kihos@catholic.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20160920
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
PMC - PMC5167712
OTO - NOTNLM
OT  - Cholesterol, HDL
OT  - Diabetes mellitus, type 2
OT  - Diabetic nephropathies
OT  - Diabetic retinopathy
OT  - Hemoglobin A1c protein, human
OT  - Triglycerides
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2016/10/22 06:00
MHDA- 2016/10/22 06:01
PMCR- 2016/12/01
CRDT- 2016/10/22 06:00
PHST- 2015/11/22 00:00 [received]
PHST- 2016/04/01 00:00 [accepted]
PHST- 2016/10/22 06:00 [pubmed]
PHST- 2016/10/22 06:01 [medline]
PHST- 2016/10/22 06:00 [entrez]
PHST- 2016/12/01 00:00 [pmc-release]
AID - 40.e30 [pii]
AID - 10.4093/dmj.2016.40.6.473 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2016 Dec;40(6):473-481. doi: 10.4093/dmj.2016.40.6.473. Epub 
      2016 Sep 20.