PMID- 27766792
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2233-6079 (Print)
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Linking)
VI  - 40
IP  - 6
DP  - 2016 Dec
TI  - Baseline-Corrected QT (QTc) Interval Is Associated with Prolongation of QTc 
      during Severe Hypoglycemia in Patients with Type 2 Diabetes Mellitus.
PG  - 463-472
LID - 10.4093/dmj.2016.40.6.463 [doi]
AB  - BACKGROUND: We investigated an association between baseline heart rate-corrected 
      QT (QTc) interval before severe hypoglycemia (SH) and prolongation of QTc 
      interval during SH in patients with type 2 diabetes mellitus (T2DM). METHODS: 
      Between January 2004 and June 2014, 208 patients with T2DM, who visited the 
      emergency department because of SH and underwent standard 12-lead 
      electrocardiography within the 6-month period before SH were consecutively 
      enrolled. The QTc interval was analyzed during the incidence of SH, and 6 months 
      before and after SH. QTc intervals of 450 ms or longer in men and 460 ms or 
      longer in women were considered abnormally prolonged. RESULTS: The mean age and 
      diabetes duration were 68.1+/-12.1 and 14.1+/-10.1 years, respectively. The mean QTc 
      intervals at baseline and SH episodes were 433+/-33 and 460+/-33 ms, respectively 
      (P<0.001). One hundred and fourteen patients (54.8%) had a prolonged QTc interval 
      during SH. There was a significant decrease in the prolonged QTc interval within 
      6 months after SH (QTc interval prolongation during SH vs. after recovery, 54.8% 
      vs. 33.8%, P<0.001). The prolonged QTc interval was significantly associated with 
      baseline QTc interval prolongation (odds ratio, 2.92; 95% confidence interval, 
      1.22 to 6.96; P=0.016) after adjusting for multiple confounders. CONCLUSION: A 
      prolonged QTc interval at baseline was significantly associated with prolongation 
      of the QTc interval during SH in patients with T2DM, suggesting the necessity of 
      QTc interval monitoring and attention to those with a prolonged QTc interval to 
      prevent SH.
FAU - Cha, Seon Ah
AU  - Cha SA
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Yun, Jae Seung
AU  - Yun JS
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Lim, Tae Seok
AU  - Lim TS
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Kang, Yoon Goo
AU  - Kang YG
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Lee, Kang Min
AU  - Lee KM
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Song, Ki Ho
AU  - Song KH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Yoo, Ki Dong
AU  - Yoo KD
AD  - Division of Cardiology, Department of Internal Medicine, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
FAU - Park, Yong Moon
AU  - Park YM
AD  - Department of Epidemiology and Biostatistics, Arnold School of Public Health, 
      University of South Carolina, Columbia, SC, USA.
FAU - Ko, Seung Hyun
AU  - Ko SH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Ahn, Yu Bae
AU  - Ahn YB
AUID- ORCID: 0000-0001-8658-2731
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, The Catholic University of Korea, Seoul, Korea. 
      ybahn@catholic.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20161005
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
PMC - PMC5167711
OTO - NOTNLM
OT  - Diabetes mellitus, type 2
OT  - QT interval
OT  - Severe hypoglycemia
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2016/10/22 06:00
MHDA- 2016/10/22 06:01
PMCR- 2016/12/01
CRDT- 2016/10/22 06:00
PHST- 2015/11/12 00:00 [received]
PHST- 2016/06/14 00:00 [accepted]
PHST- 2016/10/22 06:00 [pubmed]
PHST- 2016/10/22 06:01 [medline]
PHST- 2016/10/22 06:00 [entrez]
PHST- 2016/12/01 00:00 [pmc-release]
AID - 40.e34 [pii]
AID - 10.4093/dmj.2016.40.6.463 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2016 Dec;40(6):463-472. doi: 10.4093/dmj.2016.40.6.463. Epub 
      2016 Oct 5.