PMID- 2776841
OWN - NLM
STAT- MEDLINE
DCOM- 19891026
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 167
IP  - 1
DP  - 1989 Aug 11
TI  - Prepulse inhibition of the acoustic startle response is disrupted by 
      N-ethyl-3,4-methylenedioxyamphetamine (MDEA) in the rat.
PG  - 49-55
AB  - N-Ethyl-3,4-methylenedioxyamphetamine (MDEA) is a derivative of 
      methylenedioxyamphetamine (MDA), a substituted amphetamine with demonstrated 
      abuse liability. MDA, MDEA and a third substituted amphetamine, 
      methylenedioxymethamphetamine (MDMA), all produce a destructive action on central 
      serotonin neurons and appear to induce some similar behavioral effects. The 
      present study investigated the effects of racemic MDEA and its stereoisomers on 
      prepulse inhibition of the acoustic startle response, a behavioral model of 
      sensorimotor gating that is sensitive to psychostimulant drugs. Rats were 
      subjected to 122 dB[A] acoustic noises, some of which were preceded by a weak 80 
      dB[A] prepulse noise. In vehicle-injected control rats, the prepulse induced a 
      significant decrease in startle amplitude when compared to trials in which 
      startle stimuli were not preceded by prepulses. Administration of racemic MDEA 
      (0.3-10.0 mg/kg) and (+) MDEA (0.1-3.0 mg/kg) induced a significant attenuation 
      in prepulse inhibition, while (-) MDEA (0.3-10.0 mg/kg) did not. Racemic MDMA 
      (0.3-10.0 mg/kg) produced similar though not significant effects. These results 
      confirm a stimulant-like behavioral effect of MDEA despite its relatively modest 
      effects on dopamine markers, and support findings that the (+) stereoisomers of 
      substituted amphetamines are more potent than tha (-) stereoisomers in producing 
      psychostimulant-like biochemical and behavioral effects.
FAU - Mansbach, R S
AU  - Mansbach RS
AD  - Department of Psychiatry, University of California, San Diego, La Jolla 92093.
FAU - Braff, D L
AU  - Braff DL
FAU - Geyer, M A
AU  - Geyer MA
LA  - eng
GR  - DA 02925/DA/NIDA NIH HHS/United States
GR  - MH00188/MH/NIMH NIH HHS/United States
GR  - MH42228/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Amphetamines)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - ML1I4KK67B (3,4-methylenedioxyethamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Acoustic Stimulation
MH  - Amphetamines/*pharmacology
MH  - Analysis of Variance
MH  - Animals
MH  - Chemical Phenomena
MH  - Chemistry
MH  - Isomerism
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reflex, Startle/*drug effects
EDAT- 1989/08/11 00:00
MHDA- 1989/08/11 00:01
CRDT- 1989/08/11 00:00
PHST- 1989/08/11 00:00 [pubmed]
PHST- 1989/08/11 00:01 [medline]
PHST- 1989/08/11 00:00 [entrez]
AID - 0014-2999(89)90746-2 [pii]
AID - 10.1016/0014-2999(89)90746-2 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1989 Aug 11;167(1):49-55. doi: 10.1016/0014-2999(89)90746-2.