PMID- 27768525
OWN - NLM
STAT- MEDLINE
DCOM- 20170406
LR  - 20181202
IS  - 1532-4117 (Electronic)
IS  - 1093-4529 (Linking)
VI  - 52
IP  - 2
DP  - 2017 Jan 28
TI  - Typical airborne quinones modulate oxidative stress and cytokine expression in 
      lung epithelial A549 cells.
PG  - 127-134
LID - 10.1080/10934529.2016.1237127 [doi]
AB  - Quinones that exist in ambient particulate matter (PM) are hypothesized to be 
      associated with adverse health effects through the generation of reactive oxygen 
      species (ROS). However, the impacts of the quinones on the inflammatory processes 
      have yet to be clearly understood. In this study, we examined the oxidative 
      potentials and biological effects of typical airborne quinones in the human lung 
      epithelial A549 cells. Significant change of redox status, loss of mitochondrial 
      membrane potentials ( big up tri, openPsi) and increase of superoxide dismutase (SOD) activity were 
      induced by exposure to quinones. Some pro-inflammatory genes including 
      interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor (TNF-alpha) and 
      monocyte chemoattractant protein-1 (MCP-1); two aromatic hydrocarbon 
      receptor-regulated genes, cytochromes P450 1A1 (Cyp1a1) and cytochromes P450 1B1 
      (Cyp1b1); and oxidative stress-related gene heme oxygenase-1 (HO-1) were 
      up-regulated after quinones treatment. Among these quinones, 1,2-naphthoquinone 
      (1,2-NQ) up-regulated expressions of IL-6, IL-8, TNF-alpha, Cyp1a1, and HO-1; 
      2-methoxy-1,4-naphthoquinone (MNQ) up-regulated MCP-1, Cyp1b1, Cyp1a1, and HO-1; 
      2-methylanthraquinone (MAQ) up-regulated IL-6, IL-8, TNF-alpha, MCP-1, Cyp1b1, and 
      Cyp1a1; acenaphthenequinone (ACQ) up-regulated IL-8, TNF-alpha, MCP-1, Cyp1b1, and 
      Cyp1a1. These results suggested that all these five quinones had a considerable 
      pro-inflammatory potential by inducing oxidative stress and releasing different 
      types of cytokines/chemokines.
FAU - Sheng, Kai
AU  - Sheng K
AD  - a Department of Gerontology , Tongren Hospital, Shanghai Jiao Tong University 
      School of Medicine , Shanghai , China.
FAU - Lu, Jiahuan
AU  - Lu J
AD  - a Department of Gerontology , Tongren Hospital, Shanghai Jiao Tong University 
      School of Medicine , Shanghai , China.
LA  - eng
PT  - Journal Article
DEP - 20161021
PL  - England
TA  - J Environ Sci Health A Tox Hazard Subst Environ Eng
JT  - Journal of environmental science and health. Part A, Toxic/hazardous substances & 
      environmental engineering
JID - 9812551
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
RN  - 0 (Quinones)
SB  - IM
MH  - A549 Cells/drug effects
MH  - Air Pollutants/*toxicity
MH  - Cell Survival/drug effects
MH  - Epithelial Cells/drug effects
MH  - Humans
MH  - Lung/*cytology
MH  - Oxidative Stress/*drug effects
MH  - Particulate Matter/*toxicity
MH  - Quinones/*pharmacology
OTO - NOTNLM
OT  - Ambient particulate matter
OT  - cytokines/chemokines
OT  - inflammation
OT  - oxidative potential
OT  - quinones
EDAT- 2016/10/22 06:00
MHDA- 2017/04/07 06:00
CRDT- 2016/10/22 06:00
PHST- 2016/10/22 06:00 [pubmed]
PHST- 2017/04/07 06:00 [medline]
PHST- 2016/10/22 06:00 [entrez]
AID - 10.1080/10934529.2016.1237127 [doi]
PST - ppublish
SO  - J Environ Sci Health A Tox Hazard Subst Environ Eng. 2017 Jan 28;52(2):127-134. 
      doi: 10.1080/10934529.2016.1237127. Epub 2016 Oct 21.