PMID- 27768976
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20180106
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 112
DP  - 2017 Jan
TI  - Drug self-delivery systems for cancer therapy.
PG  - 234-247
LID - S0142-9612(16)30561-0 [pii]
LID - 10.1016/j.biomaterials.2016.10.016 [doi]
AB  - Carrier-assistant drug delivery systems (DDSs) have been rapidly established for 
      cancer therapy and great strides have been made in recent years. However, further 
      development of DDSs is retarded by the aspects such as the low drug carrying 
      capacity, carrier-induced toxicity and immunogenicity, complex synthesis 
      manipulation. Drug self-delivery systems (DSDSs), in which active drugs exhibit 
      nanoscale characteristic to realize intracellular delivery by themselves without 
      the help of nanocarriers, have been rapidly developed to address these issues. In 
      this review, we present a comprehensive summary of the recent advances in DSDSs 
      for cancer therapy. After a brief introduction to the major types of DSDSs and 
      their fabrication strategies, we emphatically discuss some representative 
      achievements of these DSDSs for passive or/and positive targeting therapy, 
      combinational therapy as well as theranostics. The design principle is explained 
      and justified, which can cast a new light on developing drug delivery systems for 
      cancer treatments.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Qin, Si-Yong
AU  - Qin SY
AD  - School of Chemistry and Materials Science, South-Central University for 
      Nationalities, Wuhan, 430074, China.
FAU - Zhang, Ai-Qing
AU  - Zhang AQ
AD  - School of Chemistry and Materials Science, South-Central University for 
      Nationalities, Wuhan, 430074, China.
FAU - Cheng, Si-Xue
AU  - Cheng SX
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education & Department of 
      Chemistry, Wuhan University, Wuhan, 430072, China.
FAU - Rong, Lei
AU  - Rong L
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education & Department of 
      Chemistry, Wuhan University, Wuhan, 430072, China.
FAU - Zhang, Xian-Zheng
AU  - Zhang XZ
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education & Department of 
      Chemistry, Wuhan University, Wuhan, 430072, China. Electronic address: 
      xz-zhang@whu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20161013
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Nanocapsules)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*administration & dosage/chemistry/pharmacokinetics
MH  - Drug Delivery Systems/*methods
MH  - *Drug Design
MH  - Humans
MH  - Nanocapsules/*administration & dosage/*chemistry
MH  - Neoplasms/*drug therapy/metabolism
OTO - NOTNLM
OT  - Cancer therapy
OT  - Drug self-delivery system
OT  - Nanoprodrug
OT  - Self-assembly
OT  - Target
OT  - Theranostics
EDAT- 2016/10/22 06:00
MHDA- 2017/12/13 06:00
CRDT- 2016/10/22 06:00
PHST- 2016/07/20 00:00 [received]
PHST- 2016/10/03 00:00 [revised]
PHST- 2016/10/11 00:00 [accepted]
PHST- 2016/10/22 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
PHST- 2016/10/22 06:00 [entrez]
AID - S0142-9612(16)30561-0 [pii]
AID - 10.1016/j.biomaterials.2016.10.016 [doi]
PST - ppublish
SO  - Biomaterials. 2017 Jan;112:234-247. doi: 10.1016/j.biomaterials.2016.10.016. Epub 
      2016 Oct 13.