PMID- 27771242
OWN - NLM
STAT- MEDLINE
DCOM- 20170726
LR  - 20220408
IS  - 1873-1449 (Electronic)
IS  - 1538-4721 (Linking)
VI  - 16
IP  - 1
DP  - 2017 Jan-Feb
TI  - Incorporating three-dimensional ultrasound into permanent breast seed implant 
      brachytherapy treatment planning.
PG  - 167-173
LID - S1538-4721(16)30551-7 [pii]
LID - 10.1016/j.brachy.2016.09.007 [doi]
AB  - PURPOSE: Planning permanent breast seed implant (PBSI) brachytherapy using CT 
      alone may reduce treatment accuracy because of differences in seroma 
      visualization compared with ultrasound (US). This study evaluates dosimetric 
      effects of seroma delineation in PBSI and the potential impact of incorporating 
      three-dimensional (3D) US into PBSI treatment planning. METHODS AND MATERIALS: 
      Spatially coregistered CT and 3D US images from 10 patients were retrospectively 
      analyzed to simulate the PBSI procedure. Seromas contoured on CT and US defined 
      clinical target volumes, CTV(CT) and CTV(US), which were expanded to create 
      planning target volumes (PTVs). PBSI plans were generated using PTV(CT) alone, 
      and the resulting coverage to PTV(US) was evaluated. To assess the potential 
      impact of transferring to an US-guided procedure, the CT-based plans were 
      centered on CTV(US). The volume encompassed by both PTVs was used to evaluate how 
      3D US can affect the planning procedure. RESULTS: Median (range) PTV(CT)V(100) 
      was 95.6% (93.3-97.3%), resulting in PTV(US) coverage of 91.5% (80.5-97.9%). 
      Centering plans on CTV(US) decreased PTV(CT)V(100) by a mean of 10 +/- 8%, and 
      increased PTV(US)V(100) by 5 +/- 4%. The combined PTVs were a mean 9+/-6% larger than 
      PTV(CT). Acceptable dosimetry to the combined PTVs resulted in sufficient 
      coverage to individual PTVs but with a mean 11 +/- 24% increase to skin dose and 
      6 +/- 8% increase in breast V(200). CONCLUSIONS: Differences in seroma 
      visualization have dosimetric effects in PBSI. CT-based plans can underdose 
      US-defined volumes and may not adequately translate to an US-guided procedure. 
      Implementing 3D US into planning can potentially compensate for differences in 
      delineation.
CI  - Copyright (c) 2016 American Brachytherapy Society. Published by Elsevier Inc. All 
      rights reserved.
FAU - Morton, Daniel
AU  - Morton D
AD  - Department of Medical Physics, BC Cancer Agency, Centre for the Southern 
      Interior, Kelowna, British Columbia, Canada; Department of Physics and Astronomy, 
      University of Victoria, Victoria, British Columbia, Canada. Electronic address: 
      dmorton@bccancer.bc.ca.
FAU - Batchelar, Deidre
AU  - Batchelar D
AD  - Department of Medical Physics, BC Cancer Agency, Centre for the Southern 
      Interior, Kelowna, British Columbia, Canada.
FAU - Hilts, Michelle
AU  - Hilts M
AD  - Department of Medical Physics, BC Cancer Agency, Centre for the Southern 
      Interior, Kelowna, British Columbia, Canada; Department of Physics and Astronomy, 
      University of Victoria, Victoria, British Columbia, Canada.
FAU - Berrang, Tanya
AU  - Berrang T
AD  - Department of Radiation Oncology, BC Cancer Agency, Vancouver Island Centre, 
      Victoria, British Columbia, Canada.
FAU - Crook, Juanita
AU  - Crook J
AD  - Department of Radiation Oncology, BC Cancer Agency, Centre for the Southern 
      Interior, Kelowna, British Columbia, Canada.
LA  - eng
PT  - Journal Article
DEP - 20161019
PL  - United States
TA  - Brachytherapy
JT  - Brachytherapy
JID - 101137600
SB  - IM
MH  - Brachytherapy/*methods
MH  - Breast Neoplasms/diagnostic imaging/*radiotherapy
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Postoperative Complications/*diagnostic imaging
MH  - Radiometry
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Adjuvant
MH  - Retrospective Studies
MH  - Seroma/*diagnostic imaging
MH  - *Tomography, X-Ray Computed
MH  - *Ultrasonography
OTO - NOTNLM
OT  - 3D ultrasound
OT  - Accelerated partial breast irradiation
OT  - Breast brachytherapy
OT  - Permanent breast seed implants
OT  - Seroma
OT  - Treatment planning
EDAT- 2016/10/25 06:00
MHDA- 2017/07/27 06:00
CRDT- 2016/10/25 06:00
PHST- 2016/07/12 00:00 [received]
PHST- 2016/09/12 00:00 [revised]
PHST- 2016/09/13 00:00 [accepted]
PHST- 2016/10/25 06:00 [pubmed]
PHST- 2017/07/27 06:00 [medline]
PHST- 2016/10/25 06:00 [entrez]
AID - S1538-4721(16)30551-7 [pii]
AID - 10.1016/j.brachy.2016.09.007 [doi]
PST - ppublish
SO  - Brachytherapy. 2017 Jan-Feb;16(1):167-173. doi: 10.1016/j.brachy.2016.09.007. 
      Epub 2016 Oct 19.