PMID- 27771376
OWN - NLM
STAT- MEDLINE
DCOM- 20170828
LR  - 20180117
IS  - 1532-8392 (Electronic)
IS  - 0046-8177 (Linking)
VI  - 61
DP  - 2017 Mar
TI  - Clinicopathological characteristics of invasive gastric Helicobacter pylori.
PG  - 19-25
LID - S0046-8177(16)30254-4 [pii]
LID - 10.1016/j.humpath.2016.09.029 [doi]
AB  - Helicobacter pylori organisms have been observed deep within the stomach mucosa 
      with an "intracellular" appearance, although the clinicopathological 
      characteristics of such cases remain poorly understood. We analyzed 18 cases of 
      deep mucosal H pylori and associated clinical (sex, age, history of H pylori 
      infection, or proton pump inhibitor [PPI] use, medications, smoking, alcohol use, 
      comorbidities, treatment response) and pathological (presence of lymphoid 
      aggregates, intestinal metaplasia, PPI effect, active and/or chronic 
      inflammation, quantity of invasive versus surface H pylori) characteristics. 
      Electron microscopy was performed on 6 cases with the highest burden of invasive 
      H pylori. Within our sample, 3 of 16 had a history of H pylori infection, 10 of 
      15 were receiving PPIs at the time of biopsy, and 12 of 13 had a negative 
      posttreatment follow-up. Histology revealed that invasive H pylori were more 
      commonly associated with chronic inflammation, in both the antrum (15/15 chronic, 
      8/15 acute) and fundus (17/18 chronic, 8/18 acute). Electron microscopy showed 
      organisms within intercellular and luminal spaces, but no intracellular 
      organisms. Deep mucosal H pylori often have an intracellular appearance but are 
      contained within intercellular and luminal spaces and are responsive to standard 
      therapy.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Dudley, Jonathan
AU  - Dudley J
AD  - Department of Pathology, Stanford University School of Medicine, Stanford, CA, 
      USA. Electronic address: jonathan.dudley@stanford.edu.
FAU - Wieczorek, Tad
AU  - Wieczorek T
AD  - Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 
      Boston, MA, USA.
FAU - Selig, Martin
AU  - Selig M
AD  - Department of Pathology, Massachusetts General Hospital and Harvard Medical 
      School, Boston, MA, USA.
FAU - Cheung, Hoiwan
AU  - Cheung H
AD  - Department of Pathology, Stanford University School of Medicine, Stanford, CA, 
      USA.
FAU - Shen, Jeanne
AU  - Shen J
AD  - Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 
      Boston, MA, USA.
FAU - Odze, Robert
AU  - Odze R
AD  - Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 
      Boston, MA, USA.
FAU - Deshpande, Vikram
AU  - Deshpande V
AD  - Department of Pathology, Massachusetts General Hospital and Harvard Medical 
      School, Boston, MA, USA.
FAU - Zukerberg, Lawrence
AU  - Zukerberg L
AD  - Department of Pathology, Massachusetts General Hospital and Harvard Medical 
      School, Boston, MA, USA.
LA  - eng
PT  - Journal Article
DEP - 20161019
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
CIN - Hum Pathol. 2017 Jul;65:248. PMID: 28456445
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Biopsy
MH  - Drug Therapy, Combination
MH  - Female
MH  - Gastric Mucosa/drug effects/*microbiology/*ultrastructure
MH  - Gastritis/drug therapy/*microbiology/*pathology
MH  - Helicobacter Infections/drug therapy/*microbiology/*pathology
MH  - Helicobacter pylori/drug effects/pathogenicity/*ultrastructure
MH  - Humans
MH  - Male
MH  - Microscopy, Electron, Transmission
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Gastric ulcers
OT  - Gastritis
OT  - Helicobacter pylori
OT  - Proton pump inhibitor
OT  - Triple therapy
EDAT- 2016/10/25 06:00
MHDA- 2017/08/29 06:00
CRDT- 2016/10/25 06:00
PHST- 2016/07/24 00:00 [received]
PHST- 2016/09/14 00:00 [revised]
PHST- 2016/09/28 00:00 [accepted]
PHST- 2016/10/25 06:00 [pubmed]
PHST- 2017/08/29 06:00 [medline]
PHST- 2016/10/25 06:00 [entrez]
AID - S0046-8177(16)30254-4 [pii]
AID - 10.1016/j.humpath.2016.09.029 [doi]
PST - ppublish
SO  - Hum Pathol. 2017 Mar;61:19-25. doi: 10.1016/j.humpath.2016.09.029. Epub 2016 Oct 
      19.