PMID- 27771570
OWN - NLM
STAT- MEDLINE
DCOM- 20170505
LR  - 20170505
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 152
DP  - 2017 Jan
TI  - Circulating levels of perfluoroalkyl substances (PFASs) and carotid artery 
      atherosclerosis.
PG  - 157-164
LID - S0013-9351(16)30759-9 [pii]
LID - 10.1016/j.envres.2016.10.002 [doi]
AB  - BACKGROUND AND OBJECTIVE: During recent years, some persistent organic pollutants 
      (POPs) have been linked to atherosclerosis. One group of POPs, the poly- and 
      perfluoroalkyl substances (PFASs) have not been investigated with regard to 
      atherosclerotic plaques. METHODS: Carotid artery atherosclerosis was assessed by 
      ultrasound in 1016 subjects aged 70 years in the Prospective Investigation of the 
      Vasculature in Uppsala Seniors (PIVUS) study. Eight PFASs were detected in >75% 
      of participants' plasma by ultra-performance liquid chromatography coupled to 
      tandem mass spectrometry (UPLC-MS/MS). RESULTS: No significant linear 
      associations were observed between the PFASs and intima-media thickness (IMT), or 
      the echogenicity in the intima-media complex (IM-GSM, a marker of lipid 
      infiltration in the artery) when men and women were analyzed together. Neither 
      was occurrence of carotid plaques related to PFASs levels. However, highly 
      significant interactions were observed between some PFASs and sex regarding both 
      IM-GSM and plaque prevalence. Perfluorononanoic acid (PFNA), perfluorodecanoic 
      acid (PFDA), and perfluoroundecanoic acid (PFUnDA), were all related to IM-GSM in 
      a positive fashion in women (p=0.002-0.003), while these relationships were 
      negative in men. The levels of PFUnDA were significantly related to carotid 
      plaque in women (OR 1.59, 95%CI 1.03-2.43, p=0.03), but not in men (OR 0.93, 
      95%CI 0.62-1.42, p=0.75). CONCLUSIONS: In this cross-sectional study, a 
      pronounced gender difference was observed regarding associations between some 
      PFASs, especially the long-chain PFUnDA, and markers of atherosclerosis, with 
      more pronounced relationships found in women. These findings suggest a 
      sex-specific role for PFASs in atherosclerosis.
CI  - Copyright A(c) 2016 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Lind, P Monica
AU  - Lind PM
AD  - Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala 
      University Uppsala, Sweden. Electronic address: monica.lind@medsci.uu.se.
FAU - Salihovic, Samira
AU  - Salihovic S
AD  - Department of Medical Sciences, Molecular Epidemiology and Science for Life 
      Laboratory, Uppsala University, Uppsala, Sweden; MTM Research Centre, School of 
      Science and Technology, Orebro University, Orebro, Sweden. Electronic address: 
      samira.salihovic@medsci.uu.se.
FAU - van Bavel, Bert
AU  - van Bavel B
AD  - MTM Research Centre, School of Science and Technology, Orebro University, Orebro, 
      Sweden. Electronic address: bert.vanbavel@oru.se.
FAU - Lind, Lars
AU  - Lind L
AD  - Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, 
      Uppsala, Sweden. Electronic address: lars.lind@medsci.uu.se.
LA  - eng
PT  - Journal Article
DEP - 20161020
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Aged
MH  - Carotid Artery Diseases/*blood/chemically induced/*epidemiology
MH  - *Carotid Intima-Media Thickness
MH  - Chromatography, High Pressure Liquid
MH  - Cross-Sectional Studies
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Fluorocarbons/*toxicity
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Sex Factors
MH  - Sweden/epidemiology
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Atherosclerotic plaques
OT  - Poly- and perfluoroalkyl substances (PFASs)
EDAT- 2016/10/25 06:00
MHDA- 2017/05/06 06:00
CRDT- 2016/10/25 06:00
PHST- 2016/06/28 00:00 [received]
PHST- 2016/10/05 00:00 [revised]
PHST- 2016/10/07 00:00 [accepted]
PHST- 2016/10/25 06:00 [pubmed]
PHST- 2017/05/06 06:00 [medline]
PHST- 2016/10/25 06:00 [entrez]
AID - S0013-9351(16)30759-9 [pii]
AID - 10.1016/j.envres.2016.10.002 [doi]
PST - ppublish
SO  - Environ Res. 2017 Jan;152:157-164. doi: 10.1016/j.envres.2016.10.002. Epub 2016 
      Oct 20.