PMID- 27775400
OWN - NLM
STAT- MEDLINE
DCOM- 20170817
LR  - 20191210
IS  - 1931-1559 (Electronic)
IS  - 0894-4105 (Print)
IS  - 0894-4105 (Linking)
VI  - 31
IP  - 1
DP  - 2017 Jan
TI  - Dynamic functional connectivity in bipolar disorder is associated with executive 
      function and processing speed: A preliminary study.
PG  - 73-83
LID - 10.1037/neu0000317 [doi]
AB  - OBJECTIVE: Disturbances in functional connectivity have been suggested to 
      contribute to cognitive and emotion processing deficits observed in bipolar 
      disorder (BD). Functional connectivity between medial prefrontal cortex (mPFC) 
      and other brain regions may be particularly abnormal. The goal of the present 
      study was to characterize the temporal dynamics of the default mode network (DMN) 
      connectivity in BD and examine its association with cognition. METHOD: In a 
      preliminary study, euthymic BD (n = 15) and healthy comparison (HC, n = 19) 
      participants underwent resting-state functional MRI, using high-resolution 
      sequences adapted from the Human Connectome Project, and completed 
      neuropsychological measures of processing speed and executive function. A 
      seed-based approach was used to measure DMN correlations in each participant, 
      with regions of interest in the mPFC, posterior cingulate cortex (PCC), and 
      lateral parietal cortex. Subsequently, to characterize temporal dynamics, 
      correlational analyses between the mPFC and other DMN nodes were repeated using a 
      sliding-window correlational analysis with subsets of the time series. RESULTS: 
      When averaged across the entire scan, there were no group differences in overall 
      connectivity strength between the mPFC and other regions of the DMN. However, 
      dynamic connectivity between the mPFC and PCC was altered in BD, such that 
      connectivity was less variable (i.e., more rigid) over time. Decreased 
      connectivity variability was associated with slower processing speed and reduced 
      cognitive set-shifting in BD patients. CONCLUSIONS: Variability in resting-state 
      functional connectivity may be an index of internetwork flexibility that is 
      reduced in BD and a correlate of ongoing cognitive impairment during periods of 
      euthymia. (PsycINFO Database Record
CI  - (c) 2016 APA, all rights reserved).
FAU - Nguyen, Tanya T
AU  - Nguyen TT
AUID- ORCID: 0000-0002-9510-9564
AD  - Mental Illness Research, Education, and Clinical Center, Veterans Affairs San 
      Diego Healthcare System.
FAU - Kovacevic, Sanja
AU  - Kovacevic S
AD  - Veterans Medical Research Foundation.
FAU - Dev, Sheena I
AU  - Dev SI
AD  - San Diego State University/University of California, San Diego Joint Doctoral 
      Program in Clinical Psychology.
FAU - Lu, Kun
AU  - Lu K
AD  - Department of Radiology, University of California, San Diego.
FAU - Liu, Thomas T
AU  - Liu TT
AUID- ORCID: 0000-0002-1978-7486
AD  - Department of Radiology, University of California, San Diego.
FAU - Eyler, Lisa T
AU  - Eyler LT
AD  - Mental Illness Research, Education, and Clinical Center, Veterans Affairs San 
      Diego Healthcare System.
LA  - eng
GR  - R01 MH083968/MH/NIMH NIH HHS/United States
GR  - T32 MH019934/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Webcast
DEP - 20161024
PL  - United States
TA  - Neuropsychology
JT  - Neuropsychology
JID - 8904467
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/diagnosis/*physiopathology/*psychology
MH  - Brain/*physiopathology
MH  - Brain Mapping
MH  - Cognition/*physiology
MH  - Cognition Disorders/physiopathology
MH  - Emotions
MH  - Executive Function/*physiology
MH  - Female
MH  - Gyrus Cinguli/physiopathology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/*physiopathology
MH  - Neuropsychological Tests/statistics & numerical data
MH  - Parietal Lobe/physiopathology
MH  - Prefrontal Cortex/*physiopathology
MH  - Psychometrics/statistics & numerical data
MH  - Reaction Time/*physiology
MH  - Reference Values
PMC - PMC5471616
MID - NIHMS867482
EDAT- 2016/10/28 06:00
MHDA- 2017/08/18 06:00
PMCR- 2018/01/01
CRDT- 2016/10/28 06:00
PHST- 2016/10/28 06:00 [pubmed]
PHST- 2017/08/18 06:00 [medline]
PHST- 2016/10/28 06:00 [entrez]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 2016-50985-001 [pii]
AID - 10.1037/neu0000317 [doi]
PST - ppublish
SO  - Neuropsychology. 2017 Jan;31(1):73-83. doi: 10.1037/neu0000317. Epub 2016 Oct 24.