PMID- 27775590
OWN - NLM
STAT- MEDLINE
DCOM- 20170328
LR  - 20181113
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 8
IP  - 10
DP  - 2016 Oct 20
TI  - High Prevalence of Hyperhomocysteinemia and Its Association with Target Organ 
      Damage in Chinese Patients with Chronic Kidney Disease.
LID - 645
AB  - Hyperhomocysteinemia (HHcy) is recognized as a risk factor for cardiovascular 
      disease. However, the prevalence of HHcy and its role in association with target 
      organ damage in patients with chronickidney disease (CKD) are not well 
      understood. This cross-sectional study included 1042 CKD patients who were 
      admitted to our hospital. Patients were divided into two groups: 
      hyperhomocysteinemia and normohomocysteinemia. Multivariable linear regression 
      analyses were used to evaluate the association between plasma homocysteine and 
      renal/cardiovascular parameters. The prevalence of HHcy in patients with CKD was 
      52.78%, and the prevalence in CKD stage 1, stage 2, stage 3, stage 4 and stage 5 
      patients was 10.73%, 29.22%, 58.71%, 75.23% and 83.75%, respectively. Patients 
      with HHcy had higher incidences of renal damage, left ventricular hypertrophy, 
      left ventricular diastolic dysfunction and abnormal carotid intima-media 
      thickness compared with patients with normohomocysteinemia (p < 0.05), while 
      multivariable linear regression analyses showed plasma homocysteine was only 
      associated with the estimated glomerular filtration rate (eGFR). eGFR, uric acid, 
      albumin, gender, hemoglobin and calciumxphosphate were associated with levels of 
      plasma homocysteine in these CKD patients. The prevalence of HHcy in Chinese 
      patients with CKD was high, and serum homocysteine levels were associated with 
      impaired renal function in these patients.
FAU - Ye, Zengchun
AU  - Ye Z
AD  - Division of Nephrology, Department of medicine, the Third Affiliated Hospital of 
      Sun Yat-Sen University, Guangzhou 510630, China. yzchun9@163.com.
FAU - Zhang, Qunzi
AU  - Zhang Q
AD  - Division of Nephrology, Department of medicine, the Third Affiliated Hospital of 
      Sun Yat-Sen University, Guangzhou 510630, China. kawayiqunzi@163.com.
FAU - Li, Yan
AU  - Li Y
AD  - Department of Pathology, the First Affiliated Hospital of Sun Yat-Sen University, 
      Guangzhou 510080, China. energyan@163.com.
FAU - Wang, Cheng
AU  - Wang C
AD  - Division of Nephrology, Department of medicine, the Third Affiliated Hospital of 
      Sun Yat-Sen University, Guangzhou 510630, China. wt770716@163.com.
FAU - Zhang, Jun
AU  - Zhang J
AD  - Division of Nephrology, Department of medicine, the Third Affiliated Hospital of 
      Sun Yat-Sen University, Guangzhou 510630, China. zj_ncjx@163.com.
FAU - Ma, Xinxin
AU  - Ma X
AD  - Division of Nephrology, Department of medicine, the Third Affiliated Hospital of 
      Sun Yat-Sen University, Guangzhou 510630, China. maxxin_09@126.com.
FAU - Peng, Hui
AU  - Peng H
AD  - Division of Nephrology, Department of medicine, the Third Affiliated Hospital of 
      Sun Yat-Sen University, Guangzhou 510630, China. elizapeng10@gmail.com.
FAU - Lou, Tanqi
AU  - Lou T
AD  - Division of Nephrology, Department of medicine, the Third Affiliated Hospital of 
      Sun Yat-Sen University, Guangzhou 510630, China. lou.tq@163.com.
LA  - eng
PT  - Journal Article
DEP - 20161020
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Calcium Phosphates)
RN  - 0 (Hemoglobins)
RN  - 0 (Serum Albumin)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 268B43MJ25 (Uric Acid)
RN  - 97Z1WI3NDX (calcium phosphate)
SB  - IM
MH  - Adult
MH  - Calcium Phosphates/blood
MH  - Carotid Arteries/pathology
MH  - Carotid Intima-Media Thickness
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Hemoglobins/analysis
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/*blood/complications/epidemiology/physiopathology
MH  - Hypertrophy, Left Ventricular/etiology
MH  - Incidence
MH  - Kidney/physiopathology
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Renal Insufficiency, Chronic/*blood/complications/pathology/physiopathology
MH  - Risk Factors
MH  - Serum Albumin/analysis
MH  - Sex Factors
MH  - Uric Acid/blood
MH  - Ventricular Dysfunction, Left/etiology
PMC - PMC5084032
OTO - NOTNLM
OT  - chronic kidney disease
OT  - hyperhomocysteinemia
COIS- The authors declare no conflict of interest. The founding sponsors had no role in 
      the design of the study; in the collection, analyses, or interpretation of data; 
      in the writing of the manuscript, and in the decision to publish the results.
EDAT- 2016/10/25 06:00
MHDA- 2017/03/30 06:00
PMCR- 2016/10/01
CRDT- 2016/10/25 06:00
PHST- 2016/08/14 00:00 [received]
PHST- 2016/09/27 00:00 [revised]
PHST- 2016/10/03 00:00 [accepted]
PHST- 2016/10/25 06:00 [pubmed]
PHST- 2017/03/30 06:00 [medline]
PHST- 2016/10/25 06:00 [entrez]
PHST- 2016/10/01 00:00 [pmc-release]
AID - nu8100645 [pii]
AID - nutrients-08-00645 [pii]
AID - 10.3390/nu8100645 [doi]
PST - epublish
SO  - Nutrients. 2016 Oct 20;8(10):645. doi: 10.3390/nu8100645.