PMID- 27776652
OWN - NLM
STAT- MEDLINE
DCOM- 20170126
LR  - 20181202
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 85
IP  - 11
DP  - 2016 Nov
TI  - Biliary tract enhancement in gadoxetic acid-enhanced MRI correlates with liver 
      function biomarkers.
PG  - 2001-2007
LID - S0720-048X(16)30272-8 [pii]
LID - 10.1016/j.ejrad.2016.09.003 [doi]
AB  - PURPOSE: To evaluate the association between gadoxetic-acid-enhanced magnetic 
      resonance (MR) imaging measurements and laboratory and clinical biomarkers of 
      liver function and fibrosis. MATERIALS AND METHODS: One hundred thirty nine 
      consecutive patients with suspected liver disease or liver tumor underwent 
      gadoxetic-acid-enhanced MR imaging. MR imaging measurements during the 
      hepatobiliary phase included biliary tract structure-to-muscle signal intensity 
      ratio (SIR). These measurements were compared with Child-Pugh classification, 
      end-stage liver disease (MELD) score, and aspartate aminotransferase-to-platelet 
      ratio index (APRI). RESULTS: The SIRs of cystic duct and common bile duct were 
      significantly correlated with Child-Pugh classification (P=0.012 for cystic duct 
      and P<0.0001 for common bile duct), MELD score (P=0.0016 and P=0.0033), and APRI 
      (P=0.0022 and P=0.0015). The sensitivity, specificity, and area under the 
      receiver-operating-characteristic curve were: (74%, 88%, 0.86) with the SIR of 
      common bile duct for the detection of patients with Child-Pugh class B or C; 
      (100%, 87%, 0.94) with the SIR of cystic duct for MELD score (>10); (65%, 76%, 
      0.70) with the SIR of common bile duct for APRI (>1.5). CONCLUSION: 
      Gadoxetic-acid contrast enhancement of cystic duct and common bile duct could be 
      used as biomarkers to assess liver function.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Noda, Yoshifumi
AU  - Noda Y
AD  - Department of Radiology, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, 
      Japan.
FAU - Goshima, Satoshi
AU  - Goshima S
AD  - Department of Radiology, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, 
      Japan. Electronic address: gossy@par.odn.ne.jp.
FAU - Kajita, Kimihiro
AU  - Kajita K
AD  - Radiology Services, Gifu University Hospital, 1-1 Yanagido, Gifu 501-1194, Japan.
FAU - Kawada, Hiroshi
AU  - Kawada H
AD  - Department of Radiology, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, 
      Japan.
FAU - Kawai, Nobuyuki
AU  - Kawai N
AD  - Department of Radiology, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, 
      Japan.
FAU - Koyasu, Hiromi
AU  - Koyasu H
AD  - Department of Radiology, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, 
      Japan.
FAU - Matsuo, Masayuki
AU  - Matsuo M
AD  - Department of Radiology, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, 
      Japan.
FAU - Bae, Kyongtae T
AU  - Bae KT
AD  - Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, 
      USA.
LA  - eng
PT  - Journal Article
DEP - 20160909
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
RN  - 0 (Biomarkers)
RN  - 0 (Contrast Media)
RN  - 0 (gadolinium ethoxybenzyl DTPA)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aspartate Aminotransferases/metabolism
MH  - Biliary Tract/*diagnostic imaging/metabolism/physiopathology
MH  - Biomarkers/*metabolism
MH  - *Contrast Media
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Liver/*diagnostic imaging/metabolism/*physiopathology
MH  - Liver Cirrhosis/*diagnostic imaging/metabolism/*physiopathology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - Common bile duct
OT  - Cystic duct
OT  - Gadoxetic acid
OT  - Liver function
OT  - Magnetic resonance imaging
EDAT- 2016/10/26 06:00
MHDA- 2017/01/27 06:00
CRDT- 2016/10/26 06:00
PHST- 2016/07/20 00:00 [received]
PHST- 2016/08/30 00:00 [revised]
PHST- 2016/09/07 00:00 [accepted]
PHST- 2016/10/26 06:00 [pubmed]
PHST- 2017/01/27 06:00 [medline]
PHST- 2016/10/26 06:00 [entrez]
AID - S0720-048X(16)30272-8 [pii]
AID - 10.1016/j.ejrad.2016.09.003 [doi]
PST - ppublish
SO  - Eur J Radiol. 2016 Nov;85(11):2001-2007. doi: 10.1016/j.ejrad.2016.09.003. Epub 
      2016 Sep 9.