PMID- 27777588
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240326
IS  - 1687-966X (Print)
IS  - 1687-9678 (Electronic)
VI  - 2016
DP  - 2016
TI  - A Transcriptomic Signature of Mouse Liver Progenitor Cells.
PG  - 5702873
LID - 5702873
AB  - Liver progenitor cells (LPCs) can proliferate extensively, are able to 
      differentiate into hepatocytes and cholangiocytes, and contribute to liver 
      regeneration. The presence of LPCs, however, often accompanies liver disease and 
      hepatocellular carcinoma (HCC), indicating that they may be a cancer stem cell. 
      Understanding LPC biology and establishing a sensitive, rapid, and reliable 
      method to detect their presence in the liver will assist diagnosis and facilitate 
      monitoring of treatment outcomes in patients with liver pathologies. A 
      transcriptomic meta-analysis of over 400 microarrays was undertaken to compare 
      LPC lines against datasets of muscle and embryonic stem cell lines, embryonic and 
      developed liver (DL), and HCC. Three gene clusters distinguishing LPCs from other 
      liver cell types were identified. Pathways overrepresented in these clusters 
      denote the proliferative nature of LPCs and their association with HCC. Our 
      analysis also revealed 26 novel markers, LPC markers, including Mcm2 and Ltbp3, 
      and eight known LPC markers, including M2pk and Ncam. These markers specified the 
      presence of LPCs in pathological liver tissue by qPCR and correlated with LPC 
      abundance determined using immunohistochemistry. These results showcase the value 
      of global transcript profiling to identify pathways and markers that may be used 
      to detect LPCs in injured or diseased liver.
FAU - Passman, Adam M
AU  - Passman AM
AUID- ORCID: 0000-0003-3212-6938
AD  - School of Chemistry and Biochemistry, The University of Western Australia, 
      Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins 
      Institute of Medical Research, Nedlands, WA 6009, Australia.
FAU - Low, Jasmine
AU  - Low J
AD  - School of Chemistry and Biochemistry, The University of Western Australia, 
      Crawley, WA 6009, Australia; ARC Centre of Excellence in Plant Energy Biology, 
      The University of Western Australia, Crawley, WA 6009, Australia.
FAU - London, Roslyn
AU  - London R
AUID- ORCID: 0000-0002-7032-2756
AD  - School of Chemistry and Biochemistry, The University of Western Australia, 
      Crawley, WA 6009, Australia.
FAU - Tirnitz-Parker, Janina E E
AU  - Tirnitz-Parker JE
AUID- ORCID: 0000-0002-3558-5892
AD  - School of Biomedical Sciences, Curtin Health Innovation Research Institute, 
      Curtin University, Bentley, WA 6102, Australia; School of Medicine and 
      Pharmacology, The University of Western Australia, Fremantle, WA 6160, Australia.
FAU - Miyajima, Atsushi
AU  - Miyajima A
AD  - Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 
      113-8654, Japan.
FAU - Tanaka, Minoru
AU  - Tanaka M
AD  - Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 
      113-8654, Japan.
FAU - Strick-Marchand, Helene
AU  - Strick-Marchand H
AD  - Unite de Genetique de la Differenciation, Institut Pasteur, 75015 Paris, France.
FAU - Darlington, Gretchen J
AU  - Darlington GJ
AD  - Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
FAU - Finch-Edmondson, Megan
AU  - Finch-Edmondson M
AUID- ORCID: 0000-0002-9628-5842
AD  - Department of Physiology, NUS Yong Loo Lin School of Medicine, Singapore 117411; 
      Mechanobiology Institute (MBI), National University of Singapore, Singapore 
      117411.
FAU - Ochsner, Scott
AU  - Ochsner S
AD  - Department of Molecular and Cellular Biology, Baylor College of Medicine, 
      Houston, TX 77030, USA.
FAU - Zhu, Cornelia
AU  - Zhu C
AD  - School of Chemistry and Biochemistry, The University of Western Australia, 
      Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins 
      Institute of Medical Research, Nedlands, WA 6009, Australia.
FAU - Whelan, James
AU  - Whelan J
AD  - ARC Centre of Excellence in Plant Energy Biology, The University of Western 
      Australia, Crawley, WA 6009, Australia; Department of Animal, Plant and Soil 
      Sciences, La Trobe University, Melbourne, VIC 3086, Australia.
FAU - Callus, Bernard A
AU  - Callus BA
AD  - School of Chemistry and Biochemistry, The University of Western Australia, 
      Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins 
      Institute of Medical Research, Nedlands, WA 6009, Australia; School of Health 
      Sciences, The University of Notre Dame Australia, Fremantle, WA 6959, Australia.
FAU - Yeoh, George C T
AU  - Yeoh GC
AUID- ORCID: 0000-0002-4740-4702
AD  - School of Chemistry and Biochemistry, The University of Western Australia, 
      Crawley, WA 6009, Australia; The Centre for Medical Research, Harry Perkins 
      Institute of Medical Research, Nedlands, WA 6009, Australia.
LA  - eng
GR  - 09-0084/AICR_/Worldwide Cancer Research/United Kingdom
PT  - Journal Article
DEP - 20161003
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC5061959
EDAT- 2016/10/26 06:00
MHDA- 2016/10/26 06:01
PMCR- 2016/10/03
CRDT- 2016/10/26 06:00
PHST- 2016/03/08 00:00 [received]
PHST- 2016/08/04 00:00 [revised]
PHST- 2016/08/14 00:00 [accepted]
PHST- 2016/10/26 06:00 [pubmed]
PHST- 2016/10/26 06:01 [medline]
PHST- 2016/10/26 06:00 [entrez]
PHST- 2016/10/03 00:00 [pmc-release]
AID - 10.1155/2016/5702873 [doi]
PST - ppublish
SO  - Stem Cells Int. 2016;2016:5702873. doi: 10.1155/2016/5702873. Epub 2016 Oct 3.