PMID- 27777890
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2225-0719 (Print)
IS  - 2310-8819 (Electronic)
IS  - 2225-0719 (Linking)
VI  - 4
IP  - 3
DP  - 2016 Sep 28
TI  - Supplementing Conventional Treatment with Pycnogenol(R) May Improve Hepatitis C 
      Virus-Associated Type 2 Diabetes: A Mini Review.
PG  - 228-233
AB  - Hepatitis C virus (HCV) infection and type 2 diabetes mellitus (T2DM) present a 
      significant health burden, with increasing complications and mortality rates 
      worldwide. Pycnogenol(R) (PYC), a natural product, possesses antidiabetic and 
      antiviral properties that may improve HCV-associated T2DM. In this review, we 
      present previously published data on the effectiveness of PYC against HCV 
      replication and T2DM. We believe that supplementing conventional treatment with 
      PYC may improve the current HCV therapy, attenuate HCV-associated T2DM, and 
      reduce the risk of complications such as cirrhosis or hepatocellular carcinoma 
      and cardiovascular disease.
FAU - Ezzikouri, Sayeh
AU  - Ezzikouri S
AD  - Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, Casablanca, 
      Morocco.
FAU - Jadid, Fatima Zahra
AU  - Jadid FZ
AD  - Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, Casablanca, 
      Morocco.
FAU - Hamdi, Salsabil
AU  - Hamdi S
AD  - Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, Casablanca, 
      Morocco.
FAU - Wakrim, Lahcen
AU  - Wakrim L
AD  - Virology Unit, Immunovirology Laboratory, Institut Pasteur du Maroc, Casablanca, 
      Morocco.
FAU - Tsukiyama-Kohara, Kyoko
AU  - Tsukiyama-Kohara K
AD  - Laboratory of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima 
      University, Kagoshima, Japan; Transboundary Animal Diseases Centre, Joint Faculty 
      of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
FAU - Benjelloun, Soumaya
AU  - Benjelloun S
AD  - Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc, Casablanca, 
      Morocco.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160729
PL  - United States
TA  - J Clin Transl Hepatol
JT  - Journal of clinical and translational hepatology
JID - 101649815
PMC - PMC5075005
OTO - NOTNLM
OT  - Complementary medicine
OT  - Hepatitis C
OT  - Pycnogenol(R)
OT  - T2DM
COIS- None
EDAT- 2016/10/26 06:00
MHDA- 2016/10/26 06:01
PMCR- 2016/07/29
CRDT- 2016/10/26 06:00
PHST- 2016/05/18 00:00 [received]
PHST- 2016/06/20 00:00 [revised]
PHST- 2016/07/07 00:00 [accepted]
PHST- 2016/10/26 06:00 [pubmed]
PHST- 2016/10/26 06:01 [medline]
PHST- 2016/10/26 06:00 [entrez]
PHST- 2016/07/29 00:00 [pmc-release]
AID - JCTH-4-3-021 [pii]
AID - 10.14218/JCTH.2016.00021 [doi]
PST - ppublish
SO  - J Clin Transl Hepatol. 2016 Sep 28;4(3):228-233. doi: 10.14218/JCTH.2016.00021. 
      Epub 2016 Jul 29.