PMID- 27778013
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180718
LR  - 20180718
IS  - 2040-3372 (Electronic)
IS  - 2040-3364 (Linking)
VI  - 8
IP  - 43
DP  - 2016 Nov 3
TI  - A field effect glucose sensor with a nanostructured amorphous In-Ga-Zn-O network.
PG  - 18469-18475
AB  - Amorphous indium gallium zinc oxide (IGZO) field effect transistors (FETs) are a 
      promising technology for a wide range of electronic applications. Herein, we 
      fabricated and characterized FETs with a nanostructured IGZO network as a sensing 
      transducer. The IGZO was patterned using colloidal lithography and 
      electrohydrodynamic printing, where an 8 mum wide nanostructured close-packed 
      hexagonal IGZO network was obtained. Electrical characterization of the 
      nanostructured IGZO network FET demonstrated a drain-source current on-off ratio 
      of 6.1 x 10(3) and effective electron mobilities of 3.6 cm(2) V(-1) s(-1). The 
      nanostructured IGZO network was functionalized by aminosilane groups with 
      cross-linked glucose oxidase. The devices demonstrated a decrease in drain-source 
      conductance and a more positive V(ON) with increasing glucose concentration. 
      These changes are ascribed to the acceptor-like surface states associated with 
      positively charged aminosilane groups attached to the nanostructured IGZO 
      surface. Continuous monitoring of the drain-source current indicates a stepwise 
      and fully reversible response to glucose concentrations with a short response 
      time. The specific catalytic reaction between the GOx enzyme and glucose 
      eliminates interference from acetaminophen/ascorbic acid. We demonstrate that 
      nanostructured IGZO FETs have improved sensitivity compared to non-nanostructured 
      IGZO for sensing glucose and can be potentially extended to other biosensor 
      technologies.
FAU - Du, Xiaosong
AU  - Du X
AD  - School of Chemical, Biological, and Environmental Engineering, Oregon State 
      University, Corvallis, Oregon 97331, USA. greg.herman@oregonstate.edu.
FAU - Li, Yajuan
AU  - Li Y
AD  - School of Chemical, Biological, and Environmental Engineering, Oregon State 
      University, Corvallis, Oregon 97331, USA. greg.herman@oregonstate.edu and College 
      of Science, Civil Aviation University of China, Tianjin, 300300, China.
FAU - Herman, Gregory S
AU  - Herman GS
AD  - School of Chemical, Biological, and Environmental Engineering, Oregon State 
      University, Corvallis, Oregon 97331, USA. greg.herman@oregonstate.edu.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nanoscale
JT  - Nanoscale
JID - 101525249
EDAT- 2016/11/04 06:00
MHDA- 2016/11/04 06:01
CRDT- 2016/11/04 06:00
PHST- 2016/11/04 06:00 [pubmed]
PHST- 2016/11/04 06:01 [medline]
PHST- 2016/11/04 06:00 [entrez]
AID - 10.1039/c6nr05134k [doi]
PST - ppublish
SO  - Nanoscale. 2016 Nov 3;8(43):18469-18475. doi: 10.1039/c6nr05134k.