PMID- 27778448
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20180507
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 9
IP  - 9
DP  - 2017 Sep
TI  - Intestinal fatty acid binding protein Ala54Thr polymorphism is associated with 
      peripheral atherosclerosis combined with type 2 diabetes mellitus.
PG  - 821-826
LID - 10.1111/1753-0407.12496 [doi]
AB  - BACKGROUND: Intestinal fatty acid-binding protein 2 (FABP2) is expressed in 
      enterocytes and binds saturated and unsaturated long-chain fatty acids. The FABP2 
      Ala54Thr polymorphism has been reported to effect lipid metabolism. The aim of 
      the present study was to assess the relationship between this polymorphism and 
      peripheral atherosclerosis combined with type 2 diabetes mellitus (T2DM) in an 
      Egyptian population. METHODS: The study was performed on 100 T2DM patients with 
      peripheral atherosclerosis and 100 control subjects. The Ala54Thr polymorphism 
      was analyzed by polymerase chain reaction-restriction fragment length 
      polymorphism, whereas serum FABP2 levels were determined using ELISA. Fasting 
      blood glucose, fasting serum insulin concentrations, HbA1c, lipid profile, body 
      mass index (BMI) and systolic and diastolic blood pressure (SBP and DBP, 
      respectively) were determined. RESULTS: There was a higher frequency of the Thr54 
      allele among the patient group (P = 0.002). In Ala54/Thr54 heterozygotes and 
      carriers of the rare Thr54/Thr54 genotype, there were significant increases in 
      BMI and FABP2. Those with the Thr54/Thr54 genotype had significantly decreased 
      high-density lipoprotein cholesterol (HDL-C) concentrations; in addition, those 
      with the Thr54/Thr54 genotype had significantly higher SBP and DBP than subjects 
      with the Ala54/Ala54 and Ala54/Thr54 genotypes. There was a positive correlation 
      between FABP2 levels and BMI, SBP and DBP, and a negative correlation with HDL-C. 
      CONCLUSIONS: The Thr54 allele of the FABP2 Ala54Thr polymorphism was associated 
      with an increased incidence of peripheral atherosclerosis combined with T2DM in 
      the population studied.
CI  - (c) 2016 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John 
      Wiley & Sons Australia, Ltd.
FAU - Khattab, Salma A
AU  - Khattab SA
AD  - Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 
      Egypt.
FAU - Abo-Elmatty, Dina M
AU  - Abo-Elmatty DM
AD  - Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 
      Egypt.
FAU - Ghattas, Maivel H
AU  - Ghattas MH
AD  - Department of Medical Biochemistry, Faculty of Medicine, Port Said University, 
      Port Said, Egypt.
FAU - Mesbah, Noha M
AU  - Mesbah NM
AD  - Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 
      Egypt.
FAU - Mehanna, Eman T
AU  - Mehanna ET
AD  - Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 
      Egypt.
LA  - eng
PT  - Journal Article
DEP - 20161209
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 2ZD004190S (Threonine)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
MH  - Adult
MH  - Alanine/genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications/*genetics
MH  - Egypt
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Fatty Acid-Binding Proteins/*genetics
MH  - Gene Frequency
MH  - Heterozygote
MH  - Humans
MH  - Middle Aged
MH  - Peripheral Arterial Disease/*complications/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Threonine/genetics
OTO - NOTNLM
OT  - 2型糖尿病
OT  - fatty acid-binding protein (FABP2)
OT  - peripheral atherosclerosis
OT  - polymorphism
OT  - type 2 diabetes mellitus
OT  - 外周动脉粥样硬化
OT  - 多态性
OT  - 脂肪酸结合蛋白(FABP2)
EDAT- 2016/10/26 06:00
MHDA- 2018/05/08 06:00
CRDT- 2016/10/26 06:00
PHST- 2016/07/06 00:00 [received]
PHST- 2016/09/29 00:00 [revised]
PHST- 2016/10/10 00:00 [accepted]
PHST- 2016/10/26 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2016/10/26 06:00 [entrez]
AID - 10.1111/1753-0407.12496 [doi]
PST - ppublish
SO  - J Diabetes. 2017 Sep;9(9):821-826. doi: 10.1111/1753-0407.12496. Epub 2016 Dec 9.