PMID- 27780134
OWN - NLM
STAT- MEDLINE
DCOM- 20170213
LR  - 20170921
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 84
DP  - 2016 Dec
TI  - Inhibitory effects of norlignans isolated from Anemarrhena asphodeloides on 
      degranulation of rat basophilic leukemia- 2H3Cells.
PG  - 1061-1066
LID - S0753-3322(16)31452-4 [pii]
LID - 10.1016/j.biopha.2016.10.039 [doi]
AB  - Anemarrhena asphodeloides is known to suppress inflammation and lower various 
      fevers. To determine the active component of A. asphodeloides, ethanol (EtOH) 
      extract of A. asphodeloides rhizomes was fractionized. The compounds isolated 
      from the dichloromethane (CH(2)Cl(2)) soluble fraction were identified as 
      4'-O-methylnyasol (1), nyasol (2), 3''-methoxynyasol (3), 
      3''-hydroxy-4''-methoxy-4''-dehydroxynyasol (4), 4-hydroxybenzaldehyde (5), and 
      4-hydroxyacetophenone (6). The four norlignans (1-4) potently inhibited the 
      release of beta-hexosaminidase from immunoglobulin E (IgE)/dinitrophenol-conjugated 
      bovine serum albumin (DNP-BSA)-treated rat basophilic leukemia (RBL)-2H3 and 
      A23187 plus phorbol 12-myristate 13-acetate co-treated isolated rat primary mast 
      cells, as markers of degranulation and histamine release. The intraperitoneal 
      treatment with the EtOH extract significantly suppressed the fetal reaction, and 
      serum histamine release induced by compound 48/80 in mice. These results suggest 
      that the four active norlignan compounds and the EtOH extract of A. asphodeloides 
      may have potential to be developed as medicines for the treatment of allergies by 
      inhibiting the activation of mast cells.
CI  - Copyright (c) 2016 Elsevier Masson SAS. All rights reserved.
FAU - Bak, Jong Phil
AU  - Bak JP
AD  - The Clinical Center for Bio-industry, Semyung University, Jecheon 390-711, South 
      Korea.
FAU - Cho, Young Mi
AU  - Cho YM
AD  - Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung 
      Hee University, Yongin 17104, South Korea.
FAU - Kim, Inhye
AU  - Kim I
AD  - Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung 
      Hee University, Yongin 17104, South Korea.
FAU - Park, Dae Won
AU  - Park DW
AD  - Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung 
      Hee University, Yongin 17104, South Korea.
FAU - Kwon, Jung Eun
AU  - Kwon JE
AD  - Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung 
      Hee University, Yongin 17104, South Korea.
FAU - Jeong, Yong Joon
AU  - Jeong YJ
AD  - Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung 
      Hee University, Yongin 17104, South Korea.
FAU - Kwak, Jong Hwan
AU  - Kwak JH
AD  - School of Pharmacy, Sungkyunkwan University, Suwon 440-746, South Korea. 
      Electronic address: jhkwak@skku.edu.
FAU - Kang, Se Chan
AU  - Kang SC
AD  - Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung 
      Hee University, Yongin 17104, South Korea. Electronic address: sckang@khu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20161022
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Lignans)
RN  - 0 (Plant Extracts)
RN  - 0 (Solvents)
RN  - 3K9958V90M (Ethanol)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Anaphylaxis/blood/chemically induced/prevention & control
MH  - *Anemarrhena/chemistry
MH  - Animals
MH  - Anti-Allergic Agents/isolation & purification/*pharmacology
MH  - Cell Degranulation/*drug effects
MH  - Cell Line, Tumor
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Ethanol/chemistry
MH  - Histamine/metabolism
MH  - Leukemia, Basophilic, Acute/metabolism/*pathology
MH  - Lignans/isolation & purification/*pharmacology
MH  - Male
MH  - Mast Cells/*drug effects/metabolism/pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Phytotherapy
MH  - Plant Extracts/isolation & purification/*pharmacology
MH  - Plants, Medicinal
MH  - Rats
MH  - Rhizome
MH  - Solvents/chemistry
MH  - p-Methoxy-N-methylphenethylamine
OTO - NOTNLM
OT  - Anemarrhena asphodeloides
OT  - Anti-allergy
OT  - Isolated rat primary mast cell (PMC)
OT  - Norlignans
OT  - Rat basophilic leukemia cell (RBL-2H3)
EDAT- 2016/10/26 06:00
MHDA- 2017/02/14 06:00
CRDT- 2016/10/26 06:00
PHST- 2016/08/29 00:00 [received]
PHST- 2016/10/05 00:00 [revised]
PHST- 2016/10/13 00:00 [accepted]
PHST- 2016/10/26 06:00 [pubmed]
PHST- 2017/02/14 06:00 [medline]
PHST- 2016/10/26 06:00 [entrez]
AID - S0753-3322(16)31452-4 [pii]
AID - 10.1016/j.biopha.2016.10.039 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2016 Dec;84:1061-1066. doi: 10.1016/j.biopha.2016.10.039. 
      Epub 2016 Oct 22.