PMID- 27780403
OWN - NLM
STAT- MEDLINE
DCOM- 20171027
LR  - 20171227
IS  - 1748-6963 (Electronic)
IS  - 1743-5889 (Linking)
VI  - 11
IP  - 22
DP  - 2016 Nov
TI  - Pluronic-attached polyamidoamine dendrimer conjugates overcome drug resistance in 
      breast cancer.
PG  - 2917-2934
AB  - AIM: To design pluronic F68 (PF68)-conjugated polyamidoamine (PAMAM) dendrimer 
      conjugates for doxorubicin (DOX) delivery for overcoming multidrug resistance, 
      and clarify the reversal mechanism. MATERIALS & METHODS: A series of PAMAM-PF68 
      conjugates were designed. The antitumor activity of the DOX-loaded conjugates was 
      evaluated against MCF-7/ADR cells, tumor spheroids and tumors. Several 
      bioinformatics were detected to characterize the reversal mechanism. RESULTS: 
      Increased antitumor activity of the DOX-loaded conjugates was achieved in vitro 
      and in vivo. The complexes induced more DOX accumulation via caveolae-mediated 
      endocytosis. After escaping from the endosome/lysosome, the nuclear trafficking 
      of DOX was achieved. Apoptosis was significantly increased by regulating 
      mitochondrial function and gene expression. CONCLUSION: With optimized PF68 
      modification, PAMAM-PF68 conjugates can significantly overcome multidrug 
      resistance in vitro and in vivo.
FAU - Wang, Meng
AU  - Wang M
AD  - Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang 
      University, Hangzhou, 310058, PR China.
FAU - Li, Ying
AU  - Li Y
AD  - Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang 
      University, Hangzhou, 310058, PR China.
FAU - HuangFu, Mingyi
AU  - HuangFu M
AD  - Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang 
      University, Hangzhou, 310058, PR China.
FAU - Xiao, Yi
AU  - Xiao Y
AD  - Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang 
      University, Hangzhou, 310058, PR China.
FAU - Zhang, Tianyuan
AU  - Zhang T
AD  - Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang 
      University, Hangzhou, 310058, PR China.
FAU - Han, Min
AU  - Han M
AD  - Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang 
      University, Hangzhou, 310058, PR China.
FAU - Xu, Donghang
AU  - Xu D
AD  - Department of Pharmacy, the Second Affiliated Hospital of Zhejiang University 
      School of Medicine, Hangzhou, 310009, PR China.
FAU - Li, Fangyuan
AU  - Li F
AD  - Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang 
      University, Hangzhou, 310058, PR China.
FAU - Ling, Daishun
AU  - Ling D
AD  - Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang 
      University, Hangzhou, 310058, PR China.
FAU - Jin, Yi
AU  - Jin Y
AD  - National Pharmaceutical Engineering Center for Solid Preparation in Chinese 
      Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 
      330006, PR China.
FAU - Gao, Jianqing
AU  - Gao J
AD  - Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang 
      University, Hangzhou, 310058, PR China.
LA  - eng
PT  - Journal Article
DEP - 20161026
PL  - England
TA  - Nanomedicine (Lond)
JT  - Nanomedicine (London, England)
JID - 101278111
RN  - 0 (Dendrimers)
RN  - 0 (Poly(amidoamine))
RN  - 0 (Polyamines)
RN  - 80168379AG (Doxorubicin)
SB  - IM
EIN - Nanomedicine (Lond). 2017 Apr;12 (8):953. PMID: 28343417
MH  - Apoptosis/*drug effects
MH  - Breast Neoplasms/*drug therapy/pathology
MH  - Dendrimers/administration & dosage/*chemistry
MH  - Doxorubicin/administration & dosage/chemistry
MH  - Drug Resistance, Neoplasm/*drug effects
MH  - Female
MH  - Humans
MH  - MCF-7 Cells
MH  - Polyamines/administration & dosage/chemistry
OTO - NOTNLM
OT  - PAMAM dendrimer
OT  - cancer treatment
OT  - drug resistance
OT  - mechanism
OT  - pluronic
EDAT- 2016/11/01 06:00
MHDA- 2017/10/28 06:00
CRDT- 2016/11/01 06:00
PHST- 2016/11/01 06:00 [pubmed]
PHST- 2017/10/28 06:00 [medline]
PHST- 2016/11/01 06:00 [entrez]
AID - 10.2217/nnm-2016-0252 [doi]
PST - ppublish
SO  - Nanomedicine (Lond). 2016 Nov;11(22):2917-2934. doi: 10.2217/nnm-2016-0252. Epub 
      2016 Oct 26.