PMID- 27780595
OWN - NLM
STAT- MEDLINE
DCOM- 20170330
LR  - 20201209
IS  - 1465-3931 (Electronic)
IS  - 0031-3025 (Linking)
VI  - 48
IP  - 7
DP  - 2016 Dec
TI  - High expression of NDRG3 associates with positive lymph node metastasis and 
      unfavourable overall survival in laryngeal squamous cell carcinoma.
PG  - 691-696
LID - S0031-3025(16)40270-9 [pii]
LID - 10.1016/j.pathol.2016.08.005 [doi]
AB  - N-myc downstream-regulated gene 3 (NDRG3), which belongs to the NDRG family, is 
      believed to play important roles in human cancer. In this present study, one-step 
      quantitative reverse transcription-polymerase chain reaction (qPCR) and western 
      blotting tests with 10 fresh-frozen laryngeal squamous cell carcinoma (LSCC) 
      samples and immunohistochemistry (IHC) analysis in 109 LSCC cases were performed 
      to investigate the relationship between NDRG3 expression and the 
      clinicopathological characteristics of LSCC. Results demonstrated that NDRG3 mRNA 
      and protein expression levels were statistically higher in LSCC tissues than that 
      in non-cancerous tissues (all p<0.05). IHC data showed that the NDRG3 protein 
      expression was remarkably correlated with lymph node metastasis (p=0.043). 
      Univariate and multivariate survival analysis implied that high NDRG3 expression 
      (p=0.004), lymph node metastasis (p=0.044) and TNM stage (p=0.020) were 
      independently associated with the unfavourable overall survival of patients with 
      LSCC. The above findings suggested that NDRG3 may be identified as a novel 
      biomarker predicting the prognosis of LSCC.
CI  - Copyright A(c) 2016 Royal College of Pathologists of Australasia. Published by 
      Elsevier B.V. All rights reserved.
FAU - Ma, Jun
AU  - Ma J
AD  - Department of Otolaryngology-Head and Neck Surgery, Anhui Medical University 
      Affiliated Anhui Provincial Hospital, Hefei, China.
FAU - Liu, Shaofeng
AU  - Liu S
AD  - Department of Otolaryngology-Head and Neck Surgery, Yiji Shan Hospital, The First 
      Affiliated Hospital of Wannan Medical College, Wuhu, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Pathology, Yiji Shan Hospital, The First Affiliated Hospital of 
      Wannan Medical College, Wuhu, China.
FAU - Zhang, Fan
AU  - Zhang F
AD  - Department of Pathology, Yiji Shan Hospital, The First Affiliated Hospital of 
      Wannan Medical College, Wuhu, China.
FAU - Wang, Sufen
AU  - Wang S
AD  - Department of Pathology, Yiji Shan Hospital, The First Affiliated Hospital of 
      Wannan Medical College, Wuhu, China.
FAU - Wu, Lifeng
AU  - Wu L
AD  - Department of Otolaryngology-Head and Neck Surgery, Yiji Shan Hospital, The First 
      Affiliated Hospital of Wannan Medical College, Wuhu, China.
FAU - Yan, Renchun
AU  - Yan R
AD  - Department of Otolaryngology-Head and Neck Surgery, Yiji Shan Hospital, The First 
      Affiliated Hospital of Wannan Medical College, Wuhu, China.
FAU - Wu, Lijuan
AU  - Wu L
AD  - Department of Otolaryngology-Head and Neck Surgery, Yiji Shan Hospital, The First 
      Affiliated Hospital of Wannan Medical College, Wuhu, China.
FAU - Wang, Chuanxi
AU  - Wang C
AD  - Department of Otolaryngology-Head and Neck Surgery, Yiji Shan Hospital, The First 
      Affiliated Hospital of Wannan Medical College, Wuhu, China.
FAU - Zha, Zhihong
AU  - Zha Z
AD  - Department of Otolaryngology-Head and Neck Surgery, Yiji Shan Hospital, The First 
      Affiliated Hospital of Wannan Medical College, Wuhu, China.
FAU - Sun, Jingwu
AU  - Sun J
AD  - Department of Otolaryngology-Head and Neck Surgery, Anhui Medical University 
      Affiliated Anhui Provincial Hospital, Hefei, China. Electronic address: 
      sunjingwu_ent@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20161022
PL  - England
TA  - Pathology
JT  - Pathology
JID - 0175411
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (NDRG3 protein, human)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*analysis
MH  - Blotting, Western
MH  - Carcinoma, Squamous Cell/mortality/*pathology
MH  - Female
MH  - Head and Neck Neoplasms/mortality/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Intracellular Signaling Peptides and Proteins
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/mortality/*pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Nerve Tissue Proteins/analysis/*biosynthesis
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Tissue Array Analysis
OTO - NOTNLM
OT  - LSCC
OT  - NDRG3
OT  - biomarker
OT  - prognosis
EDAT- 2016/10/27 06:00
MHDA- 2017/03/31 06:00
CRDT- 2016/10/27 06:00
PHST- 2016/06/05 00:00 [received]
PHST- 2016/07/30 00:00 [revised]
PHST- 2016/08/26 00:00 [accepted]
PHST- 2016/10/27 06:00 [pubmed]
PHST- 2017/03/31 06:00 [medline]
PHST- 2016/10/27 06:00 [entrez]
AID - S0031-3025(16)40270-9 [pii]
AID - 10.1016/j.pathol.2016.08.005 [doi]
PST - ppublish
SO  - Pathology. 2016 Dec;48(7):691-696. doi: 10.1016/j.pathol.2016.08.005. Epub 2016 
      Oct 22.