PMID- 27782186
OWN - NLM
STAT- MEDLINE
DCOM- 20180426
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Oct 26
TI  - Opposite-sex attraction in male mice requires testosterone-dependent regulation 
      of adult olfactory bulb neurogenesis.
PG  - 36063
LID - 10.1038/srep36063 [doi]
LID - 36063
AB  - Opposite-sex attraction in most mammals depends on the fine-tuned integration of 
      pheromonal stimuli with gonadal hormones in the brain circuits underlying sexual 
      behaviour. Neural activity in these circuits is regulated by sensory processing 
      in the accessory olfactory bulb (AOB), the first central station of the 
      vomeronasal system. Recent evidence indicates adult neurogenesis in the AOB is 
      involved in sex behaviour; however, the mechanisms underlying this function are 
      unknown. By using Semaphorin 7A knockout (Sema7A ko) mice, which show a reduced 
      number of gonadotropin-releasing-hormone neurons, small testicles and 
      subfertility, and wild-type males castrated during adulthood, we demonstrate that 
      the level of circulating testosterone regulates the sex-specific control of AOB 
      neurogenesis and the vomeronasal system activation, which influences opposite-sex 
      cue preference/attraction in mice. Overall, these data highlight adult 
      neurogenesis as a hub for the integration of pheromonal and hormonal cues that 
      control sex-specific responses in brain circuits.
FAU - Schellino, Roberta
AU  - Schellino R
AD  - Department of Life Sciences and Systems Biology, University of Turin, Turin 
      I-10123, Italy.
AD  - NICO-Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Turin 
      I-10125, Italy.
FAU - Trova, Sara
AU  - Trova S
AD  - Department of Life Sciences and Systems Biology, University of Turin, Turin 
      I-10123, Italy.
AD  - NICO-Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Turin 
      I-10125, Italy.
FAU - Cimino, Irene
AU  - Cimino I
AD  - Inserm, UMR-S 1172, Laboratory of Development and Plasticity of the 
      Neuroendocrine Brain, F-59000 Lille, France.
FAU - Farinetti, Alice
AU  - Farinetti A
AD  - Department of Neuroscience, University of Turin, Turin I-10125, Italy.
FAU - Jongbloets, Bart C
AU  - Jongbloets BC
AD  - Department of Translational Neuroscience, Brain Center Rudolf Magnus, University 
      Medical Center Utrecht, 3584 CG11 Utrecht, The Netherlands.
FAU - Pasterkamp, R Jeroen
AU  - Pasterkamp RJ
AD  - Department of Translational Neuroscience, Brain Center Rudolf Magnus, University 
      Medical Center Utrecht, 3584 CG11 Utrecht, The Netherlands.
FAU - Panzica, Giancarlo
AU  - Panzica G
AD  - NICO-Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Turin 
      I-10125, Italy.
AD  - Department of Neuroscience, University of Turin, Turin I-10125, Italy.
AD  - Neuroscience Institute of Turin (NIT), University of Turin, Turin I-10125, Italy.
FAU - Giacobini, Paolo
AU  - Giacobini P
AD  - Inserm, UMR-S 1172, Laboratory of Development and Plasticity of the 
      Neuroendocrine Brain, F-59000 Lille, France.
AD  - Univ. Lille, UMR-S 1172-JPArc-Centre de Recherche Jean-Pierre AUBERT 
      Neurosciences et Cancer, F-59000 Lille, France.
FAU - De Marchis, Silvia
AU  - De Marchis S
AD  - Department of Life Sciences and Systems Biology, University of Turin, Turin 
      I-10123, Italy.
AD  - NICO-Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Turin 
      I-10125, Italy.
AD  - Neuroscience Institute of Turin (NIT), University of Turin, Turin I-10125, Italy.
FAU - Peretto, Paolo
AU  - Peretto P
AD  - Department of Life Sciences and Systems Biology, University of Turin, Turin 
      I-10123, Italy.
AD  - NICO-Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Turin 
      I-10125, Italy.
AD  - Neuroscience Institute of Turin (NIT), University of Turin, Turin I-10125, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161026
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Antigens, CD)
RN  - 0 (Sema7a protein, mouse)
RN  - 0 (Semaphorins)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Animals
MH  - Antigens, CD/genetics/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - *Neurogenesis
MH  - Olfactory Bulb/*metabolism
MH  - Semaphorins/genetics/metabolism
MH  - *Sexual Behavior, Animal
MH  - Testosterone/genetics/*metabolism
PMC - PMC5080553
EDAT- 2016/10/27 06:00
MHDA- 2018/04/27 06:00
PMCR- 2016/10/26
CRDT- 2016/10/27 06:00
PHST- 2016/03/29 00:00 [received]
PHST- 2016/10/11 00:00 [accepted]
PHST- 2016/10/27 06:00 [pubmed]
PHST- 2018/04/27 06:00 [medline]
PHST- 2016/10/27 06:00 [entrez]
PHST- 2016/10/26 00:00 [pmc-release]
AID - srep36063 [pii]
AID - 10.1038/srep36063 [doi]
PST - epublish
SO  - Sci Rep. 2016 Oct 26;6:36063. doi: 10.1038/srep36063.