PMID- 27782707
OWN - NLM
STAT- MEDLINE
DCOM- 20170316
LR  - 20170316
IS  - 2473-4209 (Electronic)
IS  - 0094-2405 (Linking)
VI  - 43
IP  - 10
DP  - 2016 Oct
TI  - High-low reflectivity enhancement based retinal vessel projection for SD-OCT 
      images.
PG  - 5464
AB  - PURPOSE: The retinal vessel visualization from spectral-domain optical coherence 
      tomography (SD-OCT) images is important for ocular disease diagnosis and 
      multimodal retinal image processing. The purpose is to display the retinal vessel 
      in a single projection image from 3D SD-OCT images by using the light absorption 
      and shadow characteristics of the retinal vessel. METHODS: The authors present a 
      novel retinal vessel projection method for SD-OCT images, which utilizes the 
      light absorption and shadow characteristics of the retinal vessel, called 
      high-low reflectivity enhancement (HLRE) method. The reflectivity of the retinal 
      vessel increases between the internal limiting membrane and inner nuclear 
      layer-outer plexiform layer (INL-OPL) layers because of the light absorption, and 
      the reflectivity below the retinal vessel decreases because of the influence of 
      the retinal vessel shadow. A retinal vessel mask image generated based on the 
      reflectivity characteristics of the retinal vessel is used to enhance the 
      subvolume projection image restricted between the INL-OPL and Bruch's membrane 
      layers. RESULTS: Experimental results with 22 SD-OCT cubes from 12 patients and 
      10 normal persons demonstrate that the authors' method is more effective in 
      displaying the retinal vessel than the summed-voxel projection and other five 
      region restriction based projection methods. The average of the mean difference 
      between the retinal vessel and background regions based on their HLRE method is 
      0.1921. CONCLUSIONS: The proposed HLRE method was more effective for the 
      visualization of the retinal vessels than the state-of-art methods because it 
      provides higher contrast and distinction.
FAU - Chen, Qiang
AU  - Chen Q
AD  - School of Computer Science and Engineering, Nanjing University of Science and 
      Technology, Nanjing 210094, China.
FAU - Niu, Sijie
AU  - Niu S
AD  - School of Computer Science and Engineering, Nanjing University of Science and 
      Technology, Nanjing 210094, China.
FAU - Yuan, Songtao
AU  - Yuan S
AD  - Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical 
      University, Nanjing 210094, China.
FAU - Fan, Wen
AU  - Fan W
AD  - Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical 
      University, Nanjing 210094, China.
FAU - Liu, Qinghuai
AU  - Liu Q
AD  - Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical 
      University, Nanjing 210094, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Phys
JT  - Medical physics
JID - 0425746
SB  - IM
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Optical Phenomena
MH  - Retinal Vessels/*diagnostic imaging
MH  - Tomography, Optical Coherence/*methods
EDAT- 2016/10/27 06:00
MHDA- 2017/03/17 06:00
CRDT- 2016/10/27 06:00
PHST- 2016/10/27 06:00 [pubmed]
PHST- 2017/03/17 06:00 [medline]
PHST- 2016/10/27 06:00 [entrez]
AID - 10.1118/1.4962470 [doi]
PST - ppublish
SO  - Med Phys. 2016 Oct;43(10):5464. doi: 10.1118/1.4962470.