PMID- 27783183
OWN - NLM
STAT- MEDLINE
DCOM- 20170214
LR  - 20181113
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 38
IP  - 1
DP  - 2017 Jan
TI  - Association of sudomotor function with peripheral artery disease in type 2 
      diabetes.
PG  - 151-156
LID - 10.1007/s10072-016-2742-3 [doi]
AB  - Peripheral artery disease (PAD) is the major risk factor for cardiovascular 
      disease and lower extremity amputation in patients with diabetes. Autonomic 
      neuropathy is a risk factor for cardiovascular-related morbidity and mortality. 
      Sudomotor dysfunction is well established in type 2 diabetes mellitus (T2DM) and 
      reflects small fibre neuropathy, cardiovascular autonomic neuropathy and 
      peripheral sympathetic autonomic neuropathy. However, the relationship between 
      sudomotor dysfunction and PAD remains unexplored. Therefore, the aim of present 
      study was to explore the association of sudomotor function with ankle-brachial 
      index (ABI) and C-reactive protein (CRP) in T2DM. In this cross-sectional study, 
      we recruited 36 consecutive type 2 diabetes patients and 20 age- and sex-matched 
      healthy controls. Sudomotor function was assessed using Sudoscan (Sudoscan-Impeto 
      Medical Device, EZS 01750010193, Paris, France), which detects sweat gland 
      function through measurement of electrochemical skin conductance of both hands 
      and feet. Measurement of ankle-brachial ABI was carried out with sphygmomanometer 
      and Doppler device (Hadeco Bidop ES-100V3). Glycated haemoglobin (HbA1c), fasting 
      plasma glucose, and inflammatory marker CRP were also measured. Type 2 diabetic 
      patients had significantly impaired sudomotor function (48.14 +/- 8.28 vs. 
      76.48 +/- 6.72 micros), lower ABI (0.89 +/- 0.25 vs. 1.15 +/- 0.11) and elevated CRP 
      (5.32 +/- 2.41 vs. 2.45 +/- 1.11 mg/l) as compared to healthy controls, respectively 
      (p < 0.01). Sudoscan scores were found to be inversely correlated with CRP and 
      HbA1c, and directly correlated with ABI (p < 0.05) in the patients. Sudomotor 
      dysfunction is associated with significant peripheral artery disease, vascular 
      inflammation and impaired glycaemic status.
FAU - Chahal, Simran
AU  - Chahal S
AD  - Department of Pharmaceutical Sciences and Drug Research, Punjabi University, 
      Patiala, Punjab, India.
FAU - Vohra, Kanchan
AU  - Vohra K
AD  - Department of Pharmaceutical Sciences and Drug Research, Punjabi University, 
      Patiala, Punjab, India. kanchanvohra34@gmail.com.
FAU - Syngle, Ashit
AU  - Syngle A
AD  - Healing Touch City Clinic, # 547, Sector 16-D, Chandigarh, 160015, India.
AD  - Fortis Multi Speciality Hospital, Mohali, Punjab, India.
LA  - eng
PT  - Journal Article
DEP - 20161025
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Autonomic Nervous System/*physiopathology
MH  - Autonomic Nervous System Diseases/*diagnosis/physiopathology
MH  - Biomarkers/blood
MH  - Blood Glucose
MH  - Diabetes Mellitus, Type 2/*complications/physiopathology
MH  - Diabetic Neuropathies/*diagnosis/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peripheral Arterial Disease/*complications/physiopathology
MH  - Risk Factors
OTO - NOTNLM
OT  - Peripheral artery disease
OT  - Sudomotor dysfunction
OT  - Type 2 diabetes
OT  - Vascular inflammation
EDAT- 2016/10/27 06:00
MHDA- 2017/02/15 06:00
CRDT- 2016/10/27 06:00
PHST- 2016/07/07 00:00 [received]
PHST- 2016/10/17 00:00 [accepted]
PHST- 2016/10/27 06:00 [pubmed]
PHST- 2017/02/15 06:00 [medline]
PHST- 2016/10/27 06:00 [entrez]
AID - 10.1007/s10072-016-2742-3 [pii]
AID - 10.1007/s10072-016-2742-3 [doi]
PST - ppublish
SO  - Neurol Sci. 2017 Jan;38(1):151-156. doi: 10.1007/s10072-016-2742-3. Epub 2016 Oct 
      25.