PMID- 27784392
OWN - NLM
STAT- MEDLINE
DCOM- 20180510
LR  - 20221207
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 24
IP  - 5
DP  - 2016 Oct
TI  - [Identification of A Novel HLA-B*13:92 Allele and Analysis of Its 3D Model 
      Structure].
PG  - 1558-1562
LID - 10.7534/j.issn.1009-2137.2016.05.049 [doi]
AB  - OBJECTIVE: To identify a novel human leukocyte antigen (HLA) allele HLA-B*13:92 
      and analyze 3D model of HLA molecule. METHODS: Polymerase chain reaction 
      sequencing-based (PCR-SBT) was used in routine HLA typing, the B locus typing 
      results of one sample was one base mismatch with B*13:01:01, B*58:01:01 at locus 
      189, The Group Specific Sequencing Products (GSSP) which target at B*13 and B*58 
      were used to confirm difference between the new allele and highest homologous 
      allele, then the new allele was modeled by Swiss-model to its 3D structure. 
      RESULTS: The sequencing results showed that the new allele with highest 
      homologous allele B*13:01:01 was the difference in the second exon at position 
      189 C>A (codon 39 GAC>GAA), 39 Asp (D) was changed to Glu (E). The amino acid 
      substitution at residue 39 of the HLA polypeptide was located in alpha-helices of 
      antigenic peptide-biding region. CONCLUSION: This allele is a new HLA-B allele 
      found in Chinese Guangxi Zhang population and has been designated as HLA-B*13:92 
      by the World Health Organization (WHO) HLA Nomenclature Committee.
FAU - Pei, Yong-Feng
AU  - Pei YF
AD  - Nanning Institute of Transfusion Medicine, Nanning 530021, Guangxi Zhuang 
      Autonomous Region, China.
FAU - Huang, Hui-Ni
AU  - Huang HN
AD  - Nanning Institute of Transfusion Medicine, Nanning 530021, Guangxi Zhuang 
      Autonomous Region, China.
FAU - Li, Heng-Cong
AU  - Li HC
AD  - Nanning Institute of Transfusion Medicine, Nanning 530021, Guangxi Zhuang 
      Autonomous Region, China.
FAU - Wu, Guo-Guang
AU  - Wu GG
AD  - Nanning Institute of Transfusion Medicine, Nanning 530021, Guangxi Zhuang 
      Autonomous Region, China. E-mail: guangwu@szonline.net.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - *Alleles
MH  - Asian People
MH  - Base Sequence
MH  - China
MH  - Ethnicity
MH  - Exons
MH  - HLA-B Antigens
MH  - Histocompatibility Testing
MH  - Humans
MH  - Models, Molecular
MH  - Polymerase Chain Reaction
MH  - Sequence Analysis, DNA
EDAT- 2016/10/28 06:00
MHDA- 2018/05/11 06:00
CRDT- 2016/10/28 06:00
PHST- 2016/10/28 06:00 [pubmed]
PHST- 2018/05/11 06:00 [medline]
PHST- 2016/10/28 06:00 [entrez]
AID - 1009-2137(2016)05-1558-05 [pii]
AID - 10.7534/j.issn.1009-2137.2016.05.049 [doi]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Oct;24(5):1558-1562. doi: 
      10.7534/j.issn.1009-2137.2016.05.049.