PMID- 27784852
OWN - NLM
STAT- MEDLINE
DCOM- 20171003
LR  - 20171116
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 64
IP  - 3
DP  - 2017 Mar 31
TI  - Mast cell specific immunological biomarkers and metabolic syndrome among 
      middle-aged and older Chinese adults.
PG  - 245-253
LID - 10.1507/endocrj.EJ16-0388 [doi]
AB  - The main aim of this study is to explore whether these mast cell specific 
      immunological biomarkers [immunoglobulin E (IgE), chymase and tryptase] is an 
      independent risk factor of MetS and whether the combined action of these 
      biomarkers increased the associations with MetS. Three mast cell-specific 
      immunological biomarkers were measured using enzyme linked immunosorbent assay 
      (ELISA). One-way analysis of covariance and logistic regression models were used 
      for analyzing the associations between immunological biomarkers with MetS. A 
      total of 340 participants, 82 (24.1%) individuals had diabetes mellitus, 31 
      (9.1%) had MetS (without diabetes mellitus) and 110 had MetS plus diabetes 
      mellitus. After adjusting by multivariable (age, gender, smoking, and family 
      history for hypertension), compared with no diabetes mellitus or MetS group 
      (reference group), hs-CRP was associated with diabetes mellitus [OR (odds ratio): 
      2.29 (1.15-4.57, 95% CI (confidence interval), p=0.019] and MetS plus diabetes 
      mellitus [OR: 2.20 (1.05-4.61, 95% CI), p=0.036], IgE was associated with MetS 
      plus diabetes mellitus [OR: 2.38 (1.13-5.02, 95% CI), p=0.023]. After adjusting 
      by multivariable, compared with reference group, most of combined elevated 
      inflammatory or immunological biomarkers were significantly associated with 
      diabetes mellitus or MetS with or without diabetes mellitus. Patients with 
      established diabetes mellitus or MetS had different inflammatory or immunological 
      cytokine profile (such as hs-CRP, IgE, chymase, tryptase), which indicated that 
      there is an alteration in the function of the immune system in diabetes mellitus 
      or MetS patient. But these results are requested to be further demonstrated for 
      large sample population-based cohort study.
FAU - Wang, Zhen
AU  - Wang Z
AD  - Department of Clinical Medicine, School of Nursing & Medicine, Huzhou University, 
      Huzhou, Zhejiang 313000, China.
FAU - Shen, Xu-Hui
AU  - Shen XH
FAU - Feng, Wen-Ming
AU  - Feng WM
FAU - Qiu, Wei
AU  - Qiu W
LA  - eng
PT  - Journal Article
DEP - 20161027
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.21.39 (CMA1 protein, human)
RN  - EC 3.4.21.39 (Chymases)
RN  - EC 3.4.21.59 (Tryptases)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - C-Reactive Protein/*analysis
MH  - China/epidemiology
MH  - Chymases/blood/metabolism
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hyperlipidemias/physiopathology
MH  - Hypertension/physiopathology
MH  - Immunoglobulin E/*analysis
MH  - *Insulin Resistance
MH  - Male
MH  - Mass Screening
MH  - Mast Cells/*immunology/metabolism
MH  - Metabolic Syndrome/epidemiology/etiology/*immunology/metabolism
MH  - Middle Aged
MH  - Obesity/physiopathology
MH  - Overweight/physiopathology
MH  - Prediabetic State/diagnosis/etiology
MH  - Risk Factors
MH  - Tryptases/blood/metabolism
MH  - *Up-Regulation
EDAT- 2016/10/28 06:00
MHDA- 2017/10/04 06:00
CRDT- 2016/10/28 06:00
PHST- 2016/10/28 06:00 [pubmed]
PHST- 2017/10/04 06:00 [medline]
PHST- 2016/10/28 06:00 [entrez]
AID - 10.1507/endocrj.EJ16-0388 [doi]
PST - ppublish
SO  - Endocr J. 2017 Mar 31;64(3):245-253. doi: 10.1507/endocrj.EJ16-0388. Epub 2016 
      Oct 27.