PMID- 27785409
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1311-0160 (Print)
IS  - 2199-5761 (Electronic)
IS  - 1311-0160 (Linking)
VI  - 19
IP  - 1
DP  - 2016 Jul 1
TI  - PECAM-1 gene polymorphism (rs668) and subclinical markers of carotid 
      atherosclerosis in patients with type 2 diabetes mellitus.
PG  - 63-70
AB  - The platelet endothelial cell adhesion molecule 1 (PECAM-1) plays an important 
      role in many inflammatory processes, including the development of 
      atherosclerosis. Polymorphism rs668 of the PECAM-1 gene (373C/G) is functional, 
      and it was reported to be associated with increased serum levels of PECAM-1. We 
      investigated the association between the rs668 polymorphism of PECAM-1 and 
      subclinical markers of carotid atherosclerosis in subjects with type 2 diabetes 
      mellitus (T2DM). Five hundred and ninety-five T2DM subjects and 200 control 
      subjects were enrolled. The carotid intima-media thickness (CIMT) and plaque 
      characteristics (presence and structure) were assessed ultrasonographically. 
      Biochemical analyses were performed using standard biochemical methods. 
      Geno-typing of the PECAM-1 gene polymorphism (rs668) was performed using KASPar 
      assays. The control examinations were performed 3.8 +/- 0.5 years after the initial 
      examination. Higher CIMT was found in patients with T2DM in comparison with 
      subjects without T2DM. Statistically sig-nificantly faster progression of the 
      atherosclerotic markers was shown in subjects with T2DM in comparison with the 
      control group. When adjusted to other risk factors, the rs668 GG genotype was 
      associated with an increased risk of carotid plaques in subjects with T2DM. We 
      concluded that our study demonstrated a minor effect of the rs668 PECAM-1 on 
      markers of carotid atherosclerosis in subjects with T2DM.
FAU - Popovic, D
AU  - Popovic D
AD  - General Hospital Rakican, Murska Sobota, Slovenia.
FAU - Nikolajevic Starcevic, J
AU  - Nikolajevic Starcevic J
AD  - Institute of Histology and Embryology, Faculty of Medicine, University in 
      Ljubljana, Ljubljana, Slovenia.
FAU - Santl Letonja, M
AU  - Santl Letonja M
AD  - General Hospital Rakican, Murska Sobota, Slovenia.
FAU - Makuc, J
AU  - Makuc J
AD  - General Hospital Slovenj Gradec, Slovenj Gradec, Slovenia.
FAU - Cokan Vujkovac, A
AU  - Cokan Vujkovac A
AD  - General Hospital Slovenj Gradec, Slovenj Gradec, Slovenia.
FAU - Reschner, H
AU  - Reschner H
AD  - Zdravstveni Zavod Reschner, Ljubljana, Slovenia.
FAU - Bregar, D
AU  - Bregar D
AD  - General Hospital Rakican, Murska Sobota, Slovenia.
FAU - Petrovic, D
AU  - Petrovic D
LA  - eng
PT  - Journal Article
DEP - 20160802
PL  - Poland
TA  - Balkan J Med Genet
JT  - Balkan journal of medical genetics : BJMG
JID - 9806959
PMC - PMC5026281
OTO - NOTNLM
OT  - Association study
OT  - Platelet endothelial cell adhesion molecule 1 (PECAM-1)
OT  - carotid atherosclerosis
OT  - rs668 polymorphism
OT  - type 2 diabetes mellitus (T2DM)
EDAT- 2016/10/28 06:00
MHDA- 2016/10/28 06:01
PMCR- 2016/08/02
CRDT- 2016/10/28 06:00
PHST- 2016/10/28 06:00 [pubmed]
PHST- 2016/10/28 06:01 [medline]
PHST- 2016/10/28 06:00 [entrez]
PHST- 2016/08/02 00:00 [pmc-release]
AID - bjmg-2016-0008 [pii]
AID - 10.1515/bjmg-2016-0008 [doi]
PST - epublish
SO  - Balkan J Med Genet. 2016 Aug 2;19(1):63-70. doi: 10.1515/bjmg-2016-0008. 
      eCollection 2016 Jul 1.