PMID- 27785677
OWN - NLM
STAT- MEDLINE
DCOM- 20170911
LR  - 20181113
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Print)
IS  - 1569-5794 (Linking)
VI  - 33
IP  - 3
DP  - 2017 Mar
TI  - The role of left ventricular deformation in the assessment of microvascular 
      obstruction and intramyocardial haemorrhage.
PG  - 361-370
LID - 10.1007/s10554-016-1006-x [doi]
AB  - In the setting of acute ST-elevation myocardial infarction (STEMI), it remains 
      unclear which strain parameter most strongly correlates with microvascular 
      obstruction (MVO) or intramyocardial haemorrhage (IMH). We aimed to investigate 
      the association of MVO, IMH and convalescent left ventricular (LV) remodelling 
      with strain parameters measured with cardiovascular magnetic resonance (CMR). 
      Forty-three patients with reperfused STEMI and 10 age and gender matched healthy 
      controls underwent CMR within 3-days and at 3-months following reperfused STEMI. 
      Cine, T2-weighted, T2*-imaging and late gadolinium enhancement (LGE) imaging were 
      performed. Infarct size, MVO and IMH were quantified. Peak global longitudinal 
      strain (GLS), global radial strain (GRS), global circumferential strain (GCS) and 
      their strain rates were derived by feature tracking analysis of LV short-axis, 
      4-chamber and 2-chamber cines. All 43 patients and ten controls completed the 
      baseline scan and 34 patients completed 3-month scans. In multivariate 
      regression, GLS demonstrated the strongest association with MVO or IMH 
      (beta = 0.53, p < 0.001). The optimal cut-off value for GLS was -13.7% for the 
      detection of MVO or IMH (sensitivity 76% and specificity 77.8%). At follow up, 
      17% (n = 6) of patients had adverse LV remodeling (defined as an absolute 
      increase of LV end-diastolic/end-systolic volumes >20%). Baseline GLS also 
      demonstrated the strongest diagnostic performance in predicting adverse LV 
      remodelling (AUC = 0.79; 95% CI 0.60-0.98; p = 0.03). Post-reperfused STEMI, 
      baseline GLS was most closely associated with the presence of MVO or IMH. 
      Baseline GLS was more strongly associated with adverse LV remodelling than other 
      CMR parameters.
FAU - Garg, Pankaj
AU  - Garg P
AUID- ORCID: 0000-0002-5483-169X
AD  - Multidisciplinary Cardiovascular Research Centre and Division of Biomedical 
      Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of 
      Leeds, Leeds, UK.
FAU - Kidambi, Ananth
AU  - Kidambi A
AD  - Multidisciplinary Cardiovascular Research Centre and Division of Biomedical 
      Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of 
      Leeds, Leeds, UK.
FAU - Swoboda, Peter P
AU  - Swoboda PP
AD  - Multidisciplinary Cardiovascular Research Centre and Division of Biomedical 
      Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of 
      Leeds, Leeds, UK.
FAU - Foley, James R J
AU  - Foley JR
AD  - Multidisciplinary Cardiovascular Research Centre and Division of Biomedical 
      Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of 
      Leeds, Leeds, UK.
FAU - Musa, Tarique A
AU  - Musa TA
AD  - Multidisciplinary Cardiovascular Research Centre and Division of Biomedical 
      Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of 
      Leeds, Leeds, UK.
FAU - Ripley, David P
AU  - Ripley DP
AD  - Multidisciplinary Cardiovascular Research Centre and Division of Biomedical 
      Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of 
      Leeds, Leeds, UK.
FAU - Erhayiem, Bara
AU  - Erhayiem B
AD  - Multidisciplinary Cardiovascular Research Centre and Division of Biomedical 
      Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of 
      Leeds, Leeds, UK.
FAU - Dobson, Laura E
AU  - Dobson LE
AD  - Multidisciplinary Cardiovascular Research Centre and Division of Biomedical 
      Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of 
      Leeds, Leeds, UK.
FAU - McDiarmid, Adam K
AU  - McDiarmid AK
AD  - Multidisciplinary Cardiovascular Research Centre and Division of Biomedical 
      Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of 
      Leeds, Leeds, UK.
FAU - Fent, Graham J
AU  - Fent GJ
AD  - Multidisciplinary Cardiovascular Research Centre and Division of Biomedical 
      Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of 
      Leeds, Leeds, UK.
FAU - Haaf, Philip
AU  - Haaf P
AD  - Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), 
      University Hospital Basel, Basel, Switzerland.
FAU - Greenwood, John P
AU  - Greenwood JP
AD  - Multidisciplinary Cardiovascular Research Centre and Division of Biomedical 
      Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of 
      Leeds, Leeds, UK.
FAU - Plein, Sven
AU  - Plein S
AD  - Multidisciplinary Cardiovascular Research Centre and Division of Biomedical 
      Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of 
      Leeds, Leeds, UK. S.Plein@leeds.ac.uk.
LA  - eng
PT  - Journal Article
DEP - 20161026
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
SB  - IM
MH  - Aged
MH  - Biomechanical Phenomena
MH  - Case-Control Studies
MH  - Contrast Media/administration & dosage
MH  - *Coronary Circulation
MH  - Female
MH  - Hemorrhage/*diagnostic imaging/etiology/physiopathology
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - *Microcirculation
MH  - Middle Aged
MH  - *Myocardial Contraction
MH  - No-Reflow Phenomenon/*diagnostic imaging/etiology/physiopathology
MH  - Percutaneous Coronary Intervention
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
MH  - ST Elevation Myocardial Infarction/complications/*diagnostic 
      imaging/physiopathology/therapy
MH  - Stress, Mechanical
MH  - Time Factors
MH  - *Ventricular Function, Left
MH  - *Ventricular Remodeling
PMC - PMC5344946
OTO - NOTNLM
OT  - Cardiovascular magnetic resonance
OT  - Haemorrhage
OT  - Left ventricular function
OT  - Myocardial infarction
COIS- The authors declare that they have no competing interests.
EDAT- 2016/10/28 06:00
MHDA- 2017/09/12 06:00
PMCR- 2016/10/26
CRDT- 2016/10/28 06:00
PHST- 2016/08/25 00:00 [received]
PHST- 2016/10/20 00:00 [accepted]
PHST- 2016/10/28 06:00 [pubmed]
PHST- 2017/09/12 06:00 [medline]
PHST- 2016/10/28 06:00 [entrez]
PHST- 2016/10/26 00:00 [pmc-release]
AID - 10.1007/s10554-016-1006-x [pii]
AID - 1006 [pii]
AID - 10.1007/s10554-016-1006-x [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2017 Mar;33(3):361-370. doi: 10.1007/s10554-016-1006-x. 
      Epub 2016 Oct 26.