PMID- 27787389
OWN - NLM
STAT- MEDLINE
DCOM- 20170209
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 95
IP  - 43
DP  - 2016 Oct
TI  - Relationship between body weight and the increment in serum brain-derived 
      neurotrophic factor after oral glucose challenge in men with obesity and 
      metabolic syndrome: A prospective study.
PG  - e5260
LID - 10.1097/MD.0000000000005260 [doi]
LID - e5260
AB  - Brain-derived neurotrophic factor (BDNF) plays a role in energy homeostasis. 
      However, the postprandial BDNF change has not been well investigated. We 
      hypothesized that the BDNF increment after oral glucose challenge is associated 
      with body weight.To address this possibility, man adults with obesity in 
      conjunction with metabolic syndrome were compared with normal weight controls at 
      baseline in the initial cross-sectional protocol. The obese subjects then 
      underwent a 12-week program for body-weight reduction in the prospective 
      protocol. The area under the curve (AUC) of serum BDNF was recorded during a 75 g 
      oral glucose tolerant test and the BDNF AUC index was defined as [(AUC of 
      BDNF) - (fasting BDNF2 hours)]/(fasting BDNF2 hours).A total of 25 controls and 
      36 obese subjects completed the study assessments. In the cross-sectional 
      protocol, the BDNF AUC index was significantly higher in the obese subjects than 
      in the controls (9.0 +/- 16.5% vs. - 8.0 +/- 22.5%, P = 0.001). After weight 
      reduction (from 97.0 +/- 12.5 kg to 88.6 +/- 12.9 kg, P < 0.001), the percentage 
      change of body weight was significantly associated with the BDNF AUC index after 
      the study (95% CI between 0.21 and 1.82, P = 0.015). Using 6% weight reduction as 
      a cut-off value, a larger weight reduction was able to reliably predict a 
      negative BDNF AUC index.In conclusion, a high BDNF AUC index was observed for 
      obese men in this study, whereas the index value significantly decreased after 
      body-weight reduction. These findings suggest that postprandial BDNF increment 
      may be associated with obesity.
FAU - Lee, I-Te
AU  - Lee IT
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Taichung Veterans General Hospital, Taichung School of Medicine, National 
      Yang-Ming University, Taipei School of Medicine, Chung Shan Medical University 
      Center for Geriatrics and Gerontology, Taichung Veterans General Hospital 
      Institute of Medical Technology, National Chung-Hsing University, Taichung, 
      Taiwan.
FAU - Wang, Jun-Sing
AU  - Wang JS
FAU - Fu, Chia-Po
AU  - Fu CP
FAU - Lin, Shih-Yi
AU  - Lin SY
FAU - Sheu, Wayne Huey-Herng
AU  - Sheu WH
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/*metabolism
MH  - *Body Weight
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cross-Sectional Studies
MH  - Fasting/blood
MH  - Follow-Up Studies
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Male
MH  - Metabolic Syndrome/*blood/etiology/physiopathology
MH  - Middle Aged
MH  - Obesity/blood/*complications/physiopathology
MH  - Prospective Studies
MH  - Young Adult
PMC - PMC5089118
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2016/10/28 06:00
MHDA- 2017/02/10 06:00
PMCR- 2016/10/28
CRDT- 2016/10/28 06:00
PHST- 2016/10/28 06:00 [pubmed]
PHST- 2017/02/10 06:00 [medline]
PHST- 2016/10/28 06:00 [entrez]
PHST- 2016/10/28 00:00 [pmc-release]
AID - 00005792-201610250-00037 [pii]
AID - 10.1097/MD.0000000000005260 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2016 Oct;95(43):e5260. doi: 10.1097/MD.0000000000005260.