PMID- 27787985
OWN - NLM
STAT- MEDLINE
DCOM- 20170425
LR  - 20191210
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 64
IP  - 45
DP  - 2016 Nov 16
TI  - Sensitive Monitoring of Fluoroquinolones in Milk and Honey Using Multiple 
      Monolithic Fiber Solid-Phase Microextraction Coupled to Liquid Chromatography 
      Tandem Mass Spectrometry.
PG  - 8684-8693
AB  - In the present study, a new multiple monolithic fiber solid-phase microextraction 
      (MMF-SPME) based on poly(apronal-co-divinylbenzene/ethylenedimethacrylate) 
      monolith (APDE) was synthesized. The effect of the preparation parameters of APED 
      on extraction efficiency was studied thoroughly. The combination of APDE/MMF-SPME 
      with high-performance liquid chromatography tandem mass spectrometry detection 
      (HPLC/MS-MS) was developed for sensitive monitoring of ultratrace 
      fluoroquinolones (FQs) in foodstuffs, including milk and honey samples. Under the 
      optimized experimental conditions, the limits of detection (S/N = 3) for the 
      targeted FQs ranged from 0.0019 to 0.018 mug/kg in milk and 0.0010 to 0.0028 mug/kg 
      in honey. The relative standard deviations (RSDs) for method reproducibility were 
      less than 9% in all samples. The established method was successfully applied for 
      the monitoring of FQs residues in milk and honey samples with the recoveries 
      between 74.5% and 116% (RSDs were in the range 0.9-9.5%). In comparison to 
      previous methods, the developed APDE/MMF-SPME-HPLC/MS-MS showed some merits, 
      including satisfactory sensitivity, simplicity, high cost-effectiveness, and low 
      consumption of organic solvent.
FAU - Chen, Lei
AU  - Chen L
AD  - State Key Laboratory of Marine Environmental Science, Key Laboratory of the 
      Ministry of Education for Coastal and Wetland Ecosystem, College of the 
      Environment and Ecology, Xiamen University , Xiamen 361005, China.
FAU - Huang, Xiaojia
AU  - Huang X
AD  - State Key Laboratory of Marine Environmental Science, Key Laboratory of the 
      Ministry of Education for Coastal and Wetland Ecosystem, College of the 
      Environment and Ecology, Xiamen University , Xiamen 361005, China.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20161104
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Fluoroquinolones)
SB  - IM
MH  - Animals
MH  - Anti-Infective Agents/*analysis/*isolation & purification
MH  - Chromatography, High Pressure Liquid
MH  - Fluoroquinolones/*analysis/*isolation & purification
MH  - Food Contamination/analysis
MH  - Honey/*analysis
MH  - Milk/*chemistry
MH  - Solid Phase Microextraction/instrumentation/*methods
MH  - Tandem Mass Spectrometry/*methods
OTO - NOTNLM
OT  - adsorbent
OT  - fluoroquinolones
OT  - honey
OT  - milk
OT  - multiple monolithic fiber solid-phase microextraction
EDAT- 2016/10/28 06:00
MHDA- 2017/04/26 06:00
CRDT- 2016/10/28 06:00
PHST- 2016/10/28 06:00 [pubmed]
PHST- 2017/04/26 06:00 [medline]
PHST- 2016/10/28 06:00 [entrez]
AID - 10.1021/acs.jafc.6b03965 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2016 Nov 16;64(45):8684-8693. doi: 10.1021/acs.jafc.6b03965. 
      Epub 2016 Nov 4.