PMID- 27788190
OWN - NLM
STAT- MEDLINE
DCOM- 20170614
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 10
DP  - 2016
TI  - Influence of HLA-DRB1 Alleles on the Variations of Antibody Response to 
      Tuberculosis Serodiagnostic Antigens in Active Tuberculosis Patients.
PG  - e0165291
LID - 10.1371/journal.pone.0165291 [doi]
LID - e0165291
AB  - Serology-based tests for tuberculosis (TB) diagnosis, though rapid, efficient and 
      easily implemented, have so far shown unsatisfactory levels of sensitivity and 
      specificity, probably due to variations of the antibody response in TB patients. 
      The number and types of seropositive antigens vary from individual to individual. 
      The person-to-person variations of antigen recognition may be linked to genetic 
      polymorphisms of the human leukocyte antigen (HLA) class II alleles. In the 
      present study, we find that there is a significant increase in the frequency of 
      HLA-DRB1*14 (P = 2.5x10-4) among subjects with high antibody response levels 
      compared to those with low antibody levels. HLA-DRB1*15, the most frequent 
      allelic group in the studied active TB population, positively correlates with 
      subjects with low antibody response levels rather than subjects with high 
      antibody response levels (P = 0.005), which indicates the loss of relevant 
      antigens for screening of patients with this allelic group. The potential 
      association between HLA-DRB1 allelic group and individual antigens implies that 
      TB diagnostic yield could be improved by the addition of antigens screened at the 
      proteome scale in infected subjects from the HLA-DRB1*15 allelic group.
FAU - Zhou, Fangbin
AU  - Zhou F
AD  - Institute for Infectious Diseases and Vaccine Development, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Xu, Xindong
AU  - Xu X
AD  - Institute for Infectious Diseases and Vaccine Development, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Wu, Sijia
AU  - Wu S
AD  - Institute for Infectious Diseases and Vaccine Development, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Cui, Xiaobing
AU  - Cui X
AD  - Institute for Infectious Diseases and Vaccine Development, Tongji University 
      School of Medicine, Shanghai, China.
FAU - Fan, Lin
AU  - Fan L
AD  - Clinic and Research Center of Tuberculosis, Shanghai Key Lab of Tuberculosis, 
      Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 
      China.
FAU - Pan, Weiqing
AU  - Pan W
AD  - Institute for Infectious Diseases and Vaccine Development, Tongji University 
      School of Medicine, Shanghai, China.
AD  - Department of Tropical Infectious Diseases, Second Military Medical University, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20161027
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Antibodies, Bacterial/*immunology
MH  - Female
MH  - HLA-DRB1 Chains/*genetics/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Serologic Tests
MH  - Tuberculosis/*diagnosis/*genetics/immunology
PMC - PMC5082874
COIS- The authors have declared that no competing interests exist.
EDAT- 2016/10/28 06:00
MHDA- 2017/06/15 06:00
PMCR- 2016/10/27
CRDT- 2016/10/28 06:00
PHST- 2016/01/30 00:00 [received]
PHST- 2016/10/10 00:00 [accepted]
PHST- 2016/10/28 06:00 [pubmed]
PHST- 2017/06/15 06:00 [medline]
PHST- 2016/10/28 06:00 [entrez]
PHST- 2016/10/27 00:00 [pmc-release]
AID - PONE-D-16-04286 [pii]
AID - 10.1371/journal.pone.0165291 [doi]
PST - epublish
SO  - PLoS One. 2016 Oct 27;11(10):e0165291. doi: 10.1371/journal.pone.0165291. 
      eCollection 2016.