PMID- 27788494
OWN - NLM
STAT- MEDLINE
DCOM- 20180320
LR  - 20181113
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 7
IP  - 47
DP  - 2016 Nov 22
TI  - Genetic variants of MCP-1 and CCR2 genes and IgA nephropathy risk.
PG  - 77950-77957
LID - 10.18632/oncotarget.12847 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 stimulate 
      inflammation response by activating and recruiting monocytes/macrophages. MCP-1 
      and CCR2 polymorphisms were reported to be associated with various diseases. To 
      explore the relationship between MCP-1 and CCR2 polymorphisms and IgA nephropathy 
      (IgAN), we conducted this case-control study by enrolling 351 IgAN patients and 
      310 health controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were 
      calculated to evaluate potential associations of MCP-1 and CCR2 polymorphisms 
      with susceptibility and clinical parameters of IgAN. No statistical differences 
      between IgAN group and the control group in the MCP-1 -2518 and CCR2 +190 
      genotypic groups were observed (P > 0.05). Individuals with MCP-1 -2518 GG 
      genotypes had a higher blood pressure (GG vs. AA+AG: OR = 1.79, 95% CI = 
      1.07-2.99, P = 0.026) and Lee's grade (GG vs. AA+AG: OR = 2.05, 95% CI = 
      1.19-3.54, P = 0.009; GG vs. AA: OR = 2.24, 95% CI = 1.19-4.20, P = 0.01), 
      compared with patients with AA/AG genotypes. A significant association between 
      CCR2 +190 polymorphism and Lee's grades was observed (GA+AA vs. GG: OR = 2.66, 
      95% CI = 1.63-4.35, P < 0.001; GA vs. AA+GG: OR = 2.27, 95% CI = 1.39-3.70, P = 
      0.001). Our results indicated that MCP-1 and CCR2 polymorphisms may influence the 
      progression of IgAN, but not increase/decrease its susceptibility.
FAU - Gao, Jie
AU  - Gao J
AD  - Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an 710004, China.
FAU - Liu, Xinghan
AU  - Liu X
AD  - Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, 
      Xi'an 710004, China.
FAU - Wei, Linting
AU  - Wei L
AD  - Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an 710004, China.
FAU - Niu, Dan
AU  - Niu D
AD  - Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, 
      Xi'an 710061, China.
FAU - Wei, Jiali
AU  - Wei J
AD  - Department of Nephrology, Hainan general hospital, Haikou 570311, China.
FAU - Wang, Li
AU  - Wang L
AD  - Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an 710004, China.
FAU - Ge, Heng
AU  - Ge H
AD  - Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an 710004, China.
FAU - Wang, Meng
AU  - Wang M
AD  - Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, 
      Xi'an 710004, China.
FAU - Yu, Qiaoling
AU  - Yu Q
AD  - Department of Pathology, Second Affiliated Hospital of Xi'an Jiaotong University, 
      Xi'an 710004, China.
FAU - Jin, Tianbo
AU  - Jin T
AD  - National Engineering Research Center for Miniaturized Detection Systems, School 
      of Life Sciences, Northwest University, Xi'an 710069, China.
FAU - Tian, Tian
AU  - Tian T
AD  - Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, 
      Xi'an 710004, China.
FAU - Dai, Zhijun
AU  - Dai Z
AD  - Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, 
      Xi'an 710004, China.
FAU - Fu, Rongguo
AU  - Fu R
AD  - Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an 710004, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCR2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - Glomerulonephritis, IGA/*genetics/pathology
MH  - Humans
MH  - Male
MH  - Receptors, CCR2/*genetics
MH  - Risk Factors
PMC - PMC5363634
OTO - NOTNLM
OT  - IgA nephropathy
OT  - case-control study
OT  - monocyte chemoattractant protein-1
OT  - polymorphism
OT  - risk
COIS- CONFLICTS OF INTEREST The authors have declared that no competing interest 
      exists.
EDAT- 2016/10/28 06:00
MHDA- 2018/03/21 06:00
PMCR- 2016/11/22
CRDT- 2016/10/28 06:00
PHST- 2016/09/16 00:00 [received]
PHST- 2016/10/12 00:00 [accepted]
PHST- 2016/10/28 06:00 [pubmed]
PHST- 2018/03/21 06:00 [medline]
PHST- 2016/10/28 06:00 [entrez]
PHST- 2016/11/22 00:00 [pmc-release]
AID - 12847 [pii]
AID - 10.18632/oncotarget.12847 [doi]
PST - ppublish
SO  - Oncotarget. 2016 Nov 22;7(47):77950-77957. doi: 10.18632/oncotarget.12847.