PMID- 27788759
OWN - NLM
STAT- MEDLINE
DCOM- 20170302
LR  - 20181202
IS  - 1532-8686 (Electronic)
IS  - 0037-1963 (Linking)
VI  - 53
IP  - 4
DP  - 2016 Oct
TI  - Matched unrelated donor transplants-State of the art in the 21st century.
PG  - 221-229
LID - S0037-1963(16)30070-1 [pii]
LID - 10.1053/j.seminhematol.2016.07.002 [doi]
AB  - Hematopoietic stem cell transplantation (HSCT) is the therapy of choice in many 
      hematological malignant and non-malignant diseases by using human leukocyte 
      antigen (HLA)-matched siblings as stem cell source but only one third of the 
      patients will have HLA-matched siblings. Hence, physicians rely on the 
      availability of matched unrelated donors (URD). The possibility of finding a 
      matched URD is now more than 70% due to continuous expansion of URD registries 
      around the world. The use of URD in adult patients is steadily increasing and in 
      the last 8 years has superseded the numbers of matched sibling donor transplants 
      and has become the most commonly used stem cell source. There is also an 
      increasing trend to use peripheral blood (PB) stem cells rather than bone marrow 
      (BM) stem cells. Outcomes following URD transplants depend mainly upon the 
      indication and urgency of transplant, age and comorbidities of recipients, 
      cytomegalovirus (CMV) matching/mismatching between donor and the recipient, and 
      degree of HLA matching. In some studies outcome of unrelated stem cell 
      transplants in terms of treatment-related mortality (TRM), disease-free survival 
      (DFS), and overall survival (OS) is comparable to sibling donors.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Altaf, Syed Y
AU  - Altaf SY
AD  - Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United 
      Kingdom.
FAU - Apperley, Jane F
AU  - Apperley JF
AD  - Centre for Haematology, Imperial College London, London, United Kingdom.
FAU - Olavarria, Eduardo
AU  - Olavarria E
AD  - Centre for Haematology, Imperial College London, London, United Kingdom. 
      Electronic address: eduardo.olavarria@imperial.nhs.uk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160725
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
RN  - 0 (HLA Antigens)
SB  - IM
MH  - HLA Antigens/immunology
MH  - Hematologic Neoplasms/immunology/*therapy
MH  - Hematopoietic Stem Cell Transplantation
MH  - Hematopoietic Stem Cells
MH  - Humans
MH  - Treatment Outcome
MH  - *Unrelated Donors
OTO - NOTNLM
OT  - State of the art
OT  - Stem cell transplantation
OT  - Unrelated donor
EDAT- 2016/10/30 06:00
MHDA- 2017/03/03 06:00
CRDT- 2016/10/30 06:00
PHST- 2016/06/14 00:00 [received]
PHST- 2016/07/20 00:00 [accepted]
PHST- 2016/10/30 06:00 [pubmed]
PHST- 2017/03/03 06:00 [medline]
PHST- 2016/10/30 06:00 [entrez]
AID - S0037-1963(16)30070-1 [pii]
AID - 10.1053/j.seminhematol.2016.07.002 [doi]
PST - ppublish
SO  - Semin Hematol. 2016 Oct;53(4):221-229. doi: 10.1053/j.seminhematol.2016.07.002. 
      Epub 2016 Jul 25.