PMID- 27788761
OWN - NLM
STAT- MEDLINE
DCOM- 20170302
LR  - 20220317
IS  - 1532-8686 (Electronic)
IS  - 0037-1963 (Linking)
VI  - 53
IP  - 4
DP  - 2016 Oct
TI  - Umbilical cord blood cells from unrelated donor as an alternative source of 
      hematopoietic stem cells for transplantation in children and adults.
PG  - 237-245
LID - S0037-1963(16)30090-7 [pii]
LID - 10.1053/j.seminhematol.2016.08.002 [doi]
AB  - Umbilical cord blood (CB) is an alternative source of hematopoietic stem cells 
      (HSC) for patients requiring allogeneic HSC transplantation but lacking a 
      suitable human leukocyte antigen (HLA)-matched donor. Using CB has many 
      advantages, including lower HLA-matching requirements, increased donor 
      availability, and low rates of graft-versus-host disease. Furthermore, with over 
      630,000 cryopreserved volunteer CB units currently stored in international CB 
      banks worldwide, CB is rapidly available for those patients requiring urgent 
      transplantation. However, concern remains over the low HSC doses available in CB 
      grafts, resulting in delayed engraftment and poor immune reconstitution. This 
      article reviews the current use and future developments of unrelated allogeneic 
      CB transplantation (CBT). An overview of the encouraging results of CBT and the 
      comparisons with other HSC sources and transplant strategies both in children and 
      adults with malignant and non-malignant diseases are shown. We will discuss 
      important factors that need to be considered when selecting CB units for 
      transplantation to further improve the results of CBT.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Rocha, Vanderson
AU  - Rocha V
AD  - Department of Haematology, Oxford University Hospitals NHS Trust, Churchill 
      Hospital, Oxford, United Kingdom; NHS Blood and Transplant, Oxford Centre, John 
      Radcliffe Hospital, Oxford, United Kingdom; Eurocord, Hopital Saint Louis APHP, 
      University Paris VII IUH Paris, France; Department of Hematology, University of 
      Sao Paulo, Sao Paulo, Brazil. Electronic address: rocha.vanderson@hotmail.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160815
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
SB  - IM
MH  - Adult
MH  - Child
MH  - *Cord Blood Stem Cell Transplantation
MH  - Fetal Blood
MH  - Graft vs Host Disease
MH  - Hematopoietic Stem Cell Transplantation
MH  - Hematopoietic Stem Cells
MH  - Humans
MH  - *Unrelated Donors
OTO - NOTNLM
OT  - Adults and children
OT  - Clinical results
OT  - Unrelated cord blood transplantation
EDAT- 2016/10/30 06:00
MHDA- 2017/03/03 06:00
CRDT- 2016/10/30 06:00
PHST- 2016/08/08 00:00 [received]
PHST- 2016/08/09 00:00 [accepted]
PHST- 2016/10/30 06:00 [pubmed]
PHST- 2017/03/03 06:00 [medline]
PHST- 2016/10/30 06:00 [entrez]
AID - S0037-1963(16)30090-7 [pii]
AID - 10.1053/j.seminhematol.2016.08.002 [doi]
PST - ppublish
SO  - Semin Hematol. 2016 Oct;53(4):237-245. doi: 10.1053/j.seminhematol.2016.08.002. 
      Epub 2016 Aug 15.