PMID- 27788762
OWN - NLM
STAT- MEDLINE
DCOM- 20170302
LR  - 20181202
IS  - 1532-8686 (Electronic)
IS  - 0037-1963 (Linking)
VI  - 53
IP  - 4
DP  - 2016 Oct
TI  - Selecting the best haploidentical donor.
PG  - 246-251
LID - S0037-1963(16)30049-X [pii]
LID - 10.1053/j.seminhematol.2016.08.001 [doi]
AB  - The substantial evidence of the safety of human leukocyte antigen 
      (HLA)-haploidentical (haplo) blood or marrow transplantation (BMT) has led to its 
      increasing utilization. When prioritizing HLA-matched grafts, patients frequently 
      have few or no donors from whom to choose. However, a given patient may have 
      multiple suitable haplo donors. Therefore factors other than HLA-match become 
      critical for selecting the best donor. We recommend a donor selection algorithm 
      based on the donor-specific antibodies, ABO match, donor age, donor sex, and 
      cytomegalovirus (CMV) serostatus match. Despite provocative initial evidence, 
      further studies are warranted to determine whether there is any benefit to 
      selecting a haplo donor based on the number of HLA-mismatches, natural killer 
      cell alloreactivity, or the presence of non-inherited maternal HLA antigens.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - McCurdy, Shannon R
AU  - McCurdy SR
AD  - Johns Hopkins University, Baltimore, MD. Electronic address: smccurd2@jhmi.edu.
FAU - Fuchs, Ephraim J
AU  - Fuchs EJ
AD  - Johns Hopkins University, Baltimore, MD.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160815
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
RN  - 0 (ABO Blood-Group System)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - ABO Blood-Group System
MH  - HLA Antigens/immunology
MH  - *Haploidy
MH  - Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Killer Cells, Natural/immunology
MH  - *Tissue Donors
OTO - NOTNLM
OT  - Donor Selection
OT  - Haploidentical
OT  - Post-transplant cyclophosphamide
EDAT- 2016/10/30 06:00
MHDA- 2017/03/03 06:00
CRDT- 2016/10/30 06:00
PHST- 2016/05/17 00:00 [received]
PHST- 2016/08/03 00:00 [revised]
PHST- 2016/08/08 00:00 [accepted]
PHST- 2016/10/30 06:00 [pubmed]
PHST- 2017/03/03 06:00 [medline]
PHST- 2016/10/30 06:00 [entrez]
AID - S0037-1963(16)30049-X [pii]
AID - 10.1053/j.seminhematol.2016.08.001 [doi]
PST - ppublish
SO  - Semin Hematol. 2016 Oct;53(4):246-251. doi: 10.1053/j.seminhematol.2016.08.001. 
      Epub 2016 Aug 15.