PMID- 27790016
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1179-156X (Print)
IS  - 1179-156X (Electronic)
IS  - 1179-156X (Linking)
VI  - 4
DP  - 2012
TI  - The impact of tocilizumab on physical function and quality of life in patients 
      with rheumatoid arthritis: a systematic literature review and interpretation.
PG  - 87-92
AB  - OBJECTIVE: To determine the impact of tocilizumab on physical function and 
      quality of life in patients diagnosed with rheumatoid arthritis. METHODS: A 
      systematic literature review was performed to select for trials that could be 
      used to examine the impact of tocilizumab on patients in terms of health-related 
      physical function, quality of life, and quality of sleep. By examining background 
      therapy, disease duration, and remission rates, we were able to determine the 
      impact that a dose of tocilizumab has on various patients. RESULTS: A total of 
      2617 tocilizumab-treated patients and 1271 controls were available for this 
      study. Tocilizumab improved the Health Assessment Questionnaire Disability Index 
      score statistically in comparison to the controls, with odds ratios from 1.4 to 
      7.0. Tocilizumab improved the physical function measure substantially more than 
      the minimal clinically important difference (MCID) (5 units) - 8.9 and 9.7 - 
      compared to 4.1 and 5.0 for controls. Seven and nine units of improvement were 
      observed when measuring fatigue in rheumatoid arthritis patients. Using the 
      Epworth Sleepiness Scale, we found that sleep improved (from 7.7 [3.1] to 3.4 
      [2.2]). CONCLUSION: Tocilizumab improves function and quality of life and 
      decreases fatigue in patients with rheumatoid arthritis.
FAU - Townes, Shatara V
AU  - Townes SV
AD  - Department of Rheumatology, University of California-Los Angeles, Los Angeles, 
      CA, USA.
FAU - Furst, Daniel E
AU  - Furst DE
AD  - Department of Rheumatology, University of California-Los Angeles, Los Angeles, 
      CA, USA.
FAU - Thenkondar, Anuradha
AU  - Thenkondar A
AD  - Sri Ramachandra Medical College and Research Institute, Chennai, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120809
PL  - New Zealand
TA  - Open Access Rheumatol
JT  - Open access rheumatology : research and reviews
JID - 101688698
PMC - PMC5045104
OTO - NOTNLM
OT  - quality of life
OT  - randomized trials
OT  - rheumatoid arthritis
OT  - sleep
OT  - tocilizumab
EDAT- 2012/08/09 00:00
MHDA- 2012/08/09 00:01
PMCR- 2012/08/09
CRDT- 2012/08/09 00:00
PHST- 2012/08/09 00:00 [pubmed]
PHST- 2012/08/09 00:01 [medline]
PHST- 2012/08/09 00:00 [entrez]
PHST- 2012/08/09 00:00 [pmc-release]
AID - oarrr-4-087 [pii]
AID - 10.2147/OARRR.S14563 [doi]
PST - epublish
SO  - Open Access Rheumatol. 2012 Aug 9;4:87-92. doi: 10.2147/OARRR.S14563. eCollection 
      2012.